Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385445313> ?p ?o ?g. }
- W4385445313 endingPage "2069" @default.
- W4385445313 startingPage "2069" @default.
- W4385445313 abstract "Background: Drug incompatibility is defined as a physical-chemical reaction between two or more injectable drugs and that results mainly in precipitation or insolubility. Several strategies for reducing incompatibilities have been implemented empirically in intensive care units. However, these strategies have never been compared directly (and particularly in terms of the particulate load and drug mass flow rate) under standardized conditions. The objective of the present in vitro study was to evaluate the impact of various strategies for preventing incompatibility between simultaneously infused vancomycin and piperacillin/tazobactam. Methods: An in-line filter, a dilute vancomycin solution (5 mg/mL), and an alternative saline administration line were evaluated separately. The infusion line outlet was connected to a dynamic particle counter. The antibiotic concentration was measured in an HPLC-UV assay. Result: The use of an in-line filter and an alternative saline administration route did not significantly reduce the particulate load caused by vancomycin-piperacillin/tazobactam incompatibility. Dilution of the vancomycin solution was associated with a significantly lower particulate load and maintenance of the vancomycin mass flow rate. Discussion: It is important to systematically compare the efficacy of strategies for preventing drug incompatibility. The use of diluted vancomycin solution gave the best results in the case of vancomycin-piperacillin/tazobactam incompatibility." @default.
- W4385445313 created "2023-08-02" @default.
- W4385445313 creator A5009917350 @default.
- W4385445313 creator A5025647389 @default.
- W4385445313 creator A5031743990 @default.
- W4385445313 creator A5038832701 @default.
- W4385445313 creator A5040117815 @default.
- W4385445313 creator A5056245796 @default.
- W4385445313 creator A5057577085 @default.
- W4385445313 creator A5080988761 @default.
- W4385445313 creator A5092783505 @default.
- W4385445313 creator A5092783506 @default.
- W4385445313 date "2023-08-01" @default.
- W4385445313 modified "2023-09-30" @default.
- W4385445313 title "Evaluation of Strategies for Reducing Vancomycin-Piperacillin/Tazobactam Incompatibility" @default.
- W4385445313 cites W15936081 @default.
- W4385445313 cites W1750397706 @default.
- W4385445313 cites W1953180248 @default.
- W4385445313 cites W1955931112 @default.
- W4385445313 cites W1970488200 @default.
- W4385445313 cites W1974114258 @default.
- W4385445313 cites W1978855761 @default.
- W4385445313 cites W1998720764 @default.
- W4385445313 cites W2005451486 @default.
- W4385445313 cites W2007329692 @default.
- W4385445313 cites W2007714908 @default.
- W4385445313 cites W2016904985 @default.
- W4385445313 cites W2020394740 @default.
- W4385445313 cites W2027205573 @default.
- W4385445313 cites W2043071482 @default.
- W4385445313 cites W2045916299 @default.
- W4385445313 cites W2053626455 @default.
- W4385445313 cites W2055480892 @default.
- W4385445313 cites W2065310944 @default.
- W4385445313 cites W2090915944 @default.
- W4385445313 cites W2091685528 @default.
- W4385445313 cites W2096985047 @default.
- W4385445313 cites W2098582409 @default.
- W4385445313 cites W2108433768 @default.
- W4385445313 cites W2116814997 @default.
- W4385445313 cites W2130562946 @default.
- W4385445313 cites W2132117678 @default.
- W4385445313 cites W2135233586 @default.
- W4385445313 cites W2136609531 @default.
- W4385445313 cites W2139973572 @default.
- W4385445313 cites W2149186506 @default.
- W4385445313 cites W2157810116 @default.
- W4385445313 cites W2166267591 @default.
- W4385445313 cites W2167147559 @default.
- W4385445313 cites W2253025149 @default.
- W4385445313 cites W2308076572 @default.
- W4385445313 cites W2419449499 @default.
- W4385445313 cites W2502579852 @default.
- W4385445313 cites W2594768801 @default.
- W4385445313 cites W2740425739 @default.
- W4385445313 cites W2800812427 @default.
- W4385445313 cites W2805385200 @default.
- W4385445313 cites W2913364138 @default.
- W4385445313 cites W2938649073 @default.
- W4385445313 cites W2986506950 @default.
- W4385445313 cites W2989612330 @default.
- W4385445313 cites W3004626477 @default.
- W4385445313 cites W3010771088 @default.
- W4385445313 cites W3023963196 @default.
- W4385445313 cites W3134951375 @default.
- W4385445313 cites W3138507405 @default.
- W4385445313 cites W3177873096 @default.
- W4385445313 cites W4214754383 @default.
- W4385445313 cites W4282932665 @default.
- W4385445313 cites W4285388010 @default.
- W4385445313 cites W4292492963 @default.
- W4385445313 cites W4297180789 @default.
- W4385445313 cites W4321610947 @default.
- W4385445313 cites W66348315 @default.
- W4385445313 cites W2126412929 @default.
- W4385445313 doi "https://doi.org/10.3390/pharmaceutics15082069" @default.
- W4385445313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37631283" @default.
- W4385445313 hasPublicationYear "2023" @default.
- W4385445313 type Work @default.
- W4385445313 citedByCount "0" @default.
- W4385445313 crossrefType "journal-article" @default.
- W4385445313 hasAuthorship W4385445313A5009917350 @default.
- W4385445313 hasAuthorship W4385445313A5025647389 @default.
- W4385445313 hasAuthorship W4385445313A5031743990 @default.
- W4385445313 hasAuthorship W4385445313A5038832701 @default.
- W4385445313 hasAuthorship W4385445313A5040117815 @default.
- W4385445313 hasAuthorship W4385445313A5056245796 @default.
- W4385445313 hasAuthorship W4385445313A5057577085 @default.
- W4385445313 hasAuthorship W4385445313A5080988761 @default.
- W4385445313 hasAuthorship W4385445313A5092783505 @default.
- W4385445313 hasAuthorship W4385445313A5092783506 @default.
- W4385445313 hasBestOaLocation W43854453131 @default.
- W4385445313 hasConcept C185592680 @default.
- W4385445313 hasConcept C2777637488 @default.
- W4385445313 hasConcept C2777858937 @default.
- W4385445313 hasConcept C2778193466 @default.
- W4385445313 hasConcept C2778266534 @default.
- W4385445313 hasConcept C2778980435 @default.