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- W4385445802 abstract "Estrogen and progesterone, acting through their cognate receptors the estrogen receptor α (ERα) and the progesterone receptor (PR) respectively, regulate uterine biology. Using rapid immunoprecipitation and mass spectrometry (RIME) and co-immunoprecipitation, we identified TRIM28 (Tripartite motif containing 28) as a protein which complexes with ERα and PR in the regulation of uterine function. Impairment of TRIM28 expression results in the inability of the uterus to support early pregnancy through altered PR and ERα action in the uterine epithelium and stroma by suppressing PR and ERα chromatin binding. Furthermore, TRIM28 ablation in PR-expressing uterine cells results in the enrichment of a subset of TRIM28 positive and PR negative pericytes and epithelial cells with progenitor potential. In summary, our study reveals the important roles of TRIM28 in regulating endometrial cell composition and function in women, and also implies its critical functions in other hormone regulated systems." @default.
- W4385445802 created "2023-08-02" @default.
- W4385445802 creator A5042275051 @default.
- W4385445802 creator A5056950188 @default.
- W4385445802 creator A5064070422 @default.
- W4385445802 creator A5066908162 @default.
- W4385445802 creator A5069048623 @default.
- W4385445802 creator A5077909338 @default.
- W4385445802 date "2023-08-01" @default.
- W4385445802 modified "2023-10-16" @default.
- W4385445802 title "TRIM28 modulates nuclear receptor signaling to regulate uterine function" @default.
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- W4385445802 doi "https://doi.org/10.1038/s41467-023-40395-7" @default.
- W4385445802 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37528140" @default.
- W4385445802 hasPublicationYear "2023" @default.