Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385445904> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4385445904 abstract "<p>Supplementary Fig. S2. Endoplasmic reticulum stress and unfolded protein response in normal physiology and cancer Tumor cells frequently encounter endogenous and exogenous stresses that influence protein folding in the ER, including hypoxia, inflammation, nutrient deprivation, altered glycolysis, DNA damage, genomic instability, oncogene activation, and proteasome dysfunction, can cause excessive accumulation of misfolded or unfolded proteins within the ER lumen, a condition termed ER stress. As a response to prolonged ER stress conditions, the ER responds to the ER stress by activating intracellular signal transduction pathways, collectively referred to as the UPR, to restore-ER homeostasis (protective effect) or activate cell death (cytotoxic effect). The UPR signaling cascade comprises three parallel pathways that employ unique signal transduction mechanisms and are initiated by activating three conserved ER-stress sensors: IRE1, ATF6, and PERK. Furthermore, in mammals and under resting conditions, the critical ER-resident chaperone, GRP78/BiP, prevents the activation and blocks the downstream signaling of UPR by binding to the N-terminal side of stress sensor proteins, IRE-1, PERK, and ATF6 and maintains these sensors in an inactive state. When ER stress is triggered, and the ER luminal load of unfolded or misfolded proteins increases, the GRP78/BiP dissociates, activating IRE1, PERK, and ATF6 signaling cascades, leading to the activation of these UPR signaling pathways. Upon activation, the UPR can regulate many cellular events of tumor cells, including autophagy, ER biogenesis, cell survival, metastasis, angiogenesis, migration and invasion, chemoresistance, glycolysis, and proliferation. ER, Endoplasmic reticulum; UPR, unfolded protein response; PREK, protein kinase R (PKR) like endoplasmic reticulum kinase; ATF, activating transcription factor; IRE1, inositol requiring enzyme 1; GRP78, 78-kDa glucose-regulated protein/immunoglobulin-binding protein; CHOP, C/EBP homologous protein; AMPK, AMP-activated protein kinase; XBP1, X-box binding protein 1; Dr5, death receptor 5; GADD34, growth arrest and DNA damage-inducible protein 34; ERO1α, ER oxidoreductin 1; GCN2, general control non-derepressible 2.</p>" @default.
- W4385445904 created "2023-08-02" @default.
- W4385445904 creator A5001013722 @default.
- W4385445904 creator A5005400006 @default.
- W4385445904 creator A5008040226 @default.
- W4385445904 creator A5009066430 @default.
- W4385445904 creator A5016613733 @default.
- W4385445904 creator A5022552666 @default.
- W4385445904 creator A5026672802 @default.
- W4385445904 creator A5027348000 @default.
- W4385445904 creator A5039030546 @default.
- W4385445904 creator A5050902164 @default.
- W4385445904 creator A5072072889 @default.
- W4385445904 creator A5072152615 @default.
- W4385445904 creator A5081401697 @default.
- W4385445904 creator A5091964516 @default.
- W4385445904 date "2023-08-01" @default.
- W4385445904 modified "2023-09-27" @default.
- W4385445904 title "Supplementary Fig. S2 from The mTOR Signaling Pathway Interacts with the ER Stress Response and the Unfolded Protein Response in Cancer" @default.
- W4385445904 doi "https://doi.org/10.1158/0008-5472.23814797" @default.
- W4385445904 hasPublicationYear "2023" @default.
- W4385445904 type Work @default.
- W4385445904 citedByCount "0" @default.
- W4385445904 crossrefType "posted-content" @default.
- W4385445904 hasAuthorship W4385445904A5001013722 @default.
- W4385445904 hasAuthorship W4385445904A5005400006 @default.
- W4385445904 hasAuthorship W4385445904A5008040226 @default.
- W4385445904 hasAuthorship W4385445904A5009066430 @default.
- W4385445904 hasAuthorship W4385445904A5016613733 @default.
- W4385445904 hasAuthorship W4385445904A5022552666 @default.
- W4385445904 hasAuthorship W4385445904A5026672802 @default.
- W4385445904 hasAuthorship W4385445904A5027348000 @default.
- W4385445904 hasAuthorship W4385445904A5039030546 @default.
- W4385445904 hasAuthorship W4385445904A5050902164 @default.
- W4385445904 hasAuthorship W4385445904A5072072889 @default.
- W4385445904 hasAuthorship W4385445904A5072152615 @default.
- W4385445904 hasAuthorship W4385445904A5081401697 @default.
- W4385445904 hasAuthorship W4385445904A5091964516 @default.
- W4385445904 hasBestOaLocation W43854459041 @default.
- W4385445904 hasConcept C104317684 @default.
- W4385445904 hasConcept C139447449 @default.
- W4385445904 hasConcept C158617107 @default.
- W4385445904 hasConcept C158619295 @default.
- W4385445904 hasConcept C184235292 @default.
- W4385445904 hasConcept C190283241 @default.
- W4385445904 hasConcept C203522944 @default.
- W4385445904 hasConcept C2778997996 @default.
- W4385445904 hasConcept C2781331208 @default.
- W4385445904 hasConcept C54458228 @default.
- W4385445904 hasConcept C55493867 @default.
- W4385445904 hasConcept C62478195 @default.
- W4385445904 hasConcept C67705224 @default.
- W4385445904 hasConcept C86554907 @default.
- W4385445904 hasConcept C86803240 @default.
- W4385445904 hasConcept C95444343 @default.
- W4385445904 hasConcept C97029542 @default.
- W4385445904 hasConceptScore W4385445904C104317684 @default.
- W4385445904 hasConceptScore W4385445904C139447449 @default.
- W4385445904 hasConceptScore W4385445904C158617107 @default.
- W4385445904 hasConceptScore W4385445904C158619295 @default.
- W4385445904 hasConceptScore W4385445904C184235292 @default.
- W4385445904 hasConceptScore W4385445904C190283241 @default.
- W4385445904 hasConceptScore W4385445904C203522944 @default.
- W4385445904 hasConceptScore W4385445904C2778997996 @default.
- W4385445904 hasConceptScore W4385445904C2781331208 @default.
- W4385445904 hasConceptScore W4385445904C54458228 @default.
- W4385445904 hasConceptScore W4385445904C55493867 @default.
- W4385445904 hasConceptScore W4385445904C62478195 @default.
- W4385445904 hasConceptScore W4385445904C67705224 @default.
- W4385445904 hasConceptScore W4385445904C86554907 @default.
- W4385445904 hasConceptScore W4385445904C86803240 @default.
- W4385445904 hasConceptScore W4385445904C95444343 @default.
- W4385445904 hasConceptScore W4385445904C97029542 @default.
- W4385445904 hasLocation W43854459041 @default.
- W4385445904 hasOpenAccess W4385445904 @default.
- W4385445904 hasPrimaryLocation W43854459041 @default.
- W4385445904 hasRelatedWork W1489883635 @default.
- W4385445904 hasRelatedWork W1995054388 @default.
- W4385445904 hasRelatedWork W2009062388 @default.
- W4385445904 hasRelatedWork W2072667779 @default.
- W4385445904 hasRelatedWork W2339673893 @default.
- W4385445904 hasRelatedWork W2610373932 @default.
- W4385445904 hasRelatedWork W2619405506 @default.
- W4385445904 hasRelatedWork W2921600075 @default.
- W4385445904 hasRelatedWork W3142122528 @default.
- W4385445904 hasRelatedWork W3165256562 @default.
- W4385445904 isParatext "false" @default.
- W4385445904 isRetracted "false" @default.
- W4385445904 workType "article" @default.