Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385447832> ?p ?o ?g. }
- W4385447832 abstract "Abstract BACKGROUND Pharmacological interference is considered to be a successful approach to inhibit advanced glycation end‐products (AGEs) production and to block AGEs‐induced diseases. Some synthetic medicines are effective for inhibiting the glycation reaction, but they cannot be widely applied in clinical as a result of their side effects and security concerns. The present study uses blueberry anthocyanins extract (BAE) to attenuate AGEs formation and AGEs‐induced inflammatory response in vitro. RESULTS In a bovine serum albumin‐glucose model, BAE showed similar inhibitory activity on AGEs compared to the synthetic anti‐glycation agent (aminoguanidine). The results showed that BAE exhibit strong anti‐glycative action by scavenging glycosylated intermediates (Schiff base, fructosamine and α‐dicarbonyl compounds), attenuating the molecular aggregation and amyloid‐like fibrils formation, and preventing conformational modification. Additionally, BAE was found to dose‐dependently inhibit the AGEs‐induced secretions of nitric oxide and pro‐inflammatory cytokines (interleukin‐6, monocyte chemoattractant protein‐1 and tumor necrosis factor‐α) in RAW264.7 cells. The anti‐inflammation activity of BAE was mediated by down‐regulating the expressions of critical inflammatory markers, inducible nitric oxide synthase and cyclooxygenase‐2, through nuclear factor‐kappa B signaling pathways inhibition. CONCLUSION BAE could serve as a natural inhibitor for controlling AGEs and AGEs‐induced chronic inflammation. © 2023 Society of Chemical Industry." @default.
- W4385447832 created "2023-08-02" @default.
- W4385447832 creator A5024581011 @default.
- W4385447832 creator A5028361247 @default.
- W4385447832 creator A5039588628 @default.
- W4385447832 creator A5050015893 @default.
- W4385447832 creator A5066786573 @default.
- W4385447832 creator A5068730076 @default.
- W4385447832 creator A5086291621 @default.
- W4385447832 date "2023-08-16" @default.
- W4385447832 modified "2023-09-27" @default.
- W4385447832 title "Blueberry anthocyanins extract inhibits advanced glycation end‐products (<scp>AGEs</scp>) production and <scp>AGEs</scp>‐stimulated inflammation in <scp>RAW264</scp>.7 cells" @default.
- W4385447832 cites W1767456845 @default.
- W4385447832 cites W1852340166 @default.
- W4385447832 cites W1987989563 @default.
- W4385447832 cites W2006431138 @default.
- W4385447832 cites W2014113710 @default.
- W4385447832 cites W2034623336 @default.
- W4385447832 cites W2043014968 @default.
- W4385447832 cites W2119271907 @default.
- W4385447832 cites W2149117731 @default.
- W4385447832 cites W2160544077 @default.
- W4385447832 cites W2232778138 @default.
- W4385447832 cites W2324473388 @default.
- W4385447832 cites W2515731681 @default.
- W4385447832 cites W2556782920 @default.
- W4385447832 cites W2560360961 @default.
- W4385447832 cites W2766629683 @default.
- W4385447832 cites W2770242296 @default.
- W4385447832 cites W2770476255 @default.
- W4385447832 cites W2785766768 @default.
- W4385447832 cites W2793343263 @default.
- W4385447832 cites W2802116732 @default.
- W4385447832 cites W2809928909 @default.
- W4385447832 cites W2883562611 @default.
- W4385447832 cites W2922000903 @default.
- W4385447832 cites W2935890931 @default.
- W4385447832 cites W2963957709 @default.
- W4385447832 cites W2985467991 @default.
- W4385447832 cites W2996242342 @default.
- W4385447832 cites W3001826491 @default.
- W4385447832 cites W3007573634 @default.
- W4385447832 cites W3040862916 @default.
- W4385447832 cites W3087086521 @default.
- W4385447832 cites W3115889599 @default.
- W4385447832 cites W3135549351 @default.
- W4385447832 cites W3137562009 @default.
- W4385447832 cites W3160126628 @default.
- W4385447832 cites W3165480716 @default.
- W4385447832 cites W3189502304 @default.
- W4385447832 cites W3195144173 @default.
- W4385447832 cites W3199431018 @default.
- W4385447832 cites W3217698376 @default.
- W4385447832 cites W4220728860 @default.
- W4385447832 cites W4220778020 @default.
- W4385447832 cites W4223542076 @default.
- W4385447832 cites W4224232989 @default.
- W4385447832 cites W4308929453 @default.
- W4385447832 doi "https://doi.org/10.1002/jsfa.12893" @default.
- W4385447832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37528063" @default.
- W4385447832 hasPublicationYear "2023" @default.
- W4385447832 type Work @default.
- W4385447832 citedByCount "0" @default.
- W4385447832 crossrefType "journal-article" @default.
- W4385447832 hasAuthorship W4385447832A5024581011 @default.
- W4385447832 hasAuthorship W4385447832A5028361247 @default.
- W4385447832 hasAuthorship W4385447832A5039588628 @default.
- W4385447832 hasAuthorship W4385447832A5050015893 @default.
- W4385447832 hasAuthorship W4385447832A5066786573 @default.
- W4385447832 hasAuthorship W4385447832A5068730076 @default.
- W4385447832 hasAuthorship W4385447832A5086291621 @default.
- W4385447832 hasBestOaLocation W43854478321 @default.
- W4385447832 hasConcept C147990577 @default.
- W4385447832 hasConcept C170493617 @default.
- W4385447832 hasConcept C178790620 @default.
- W4385447832 hasConcept C17991360 @default.
- W4385447832 hasConcept C185592680 @default.
- W4385447832 hasConcept C203014093 @default.
- W4385447832 hasConcept C2776914184 @default.
- W4385447832 hasConcept C2776997535 @default.
- W4385447832 hasConcept C2777622882 @default.
- W4385447832 hasConcept C519581460 @default.
- W4385447832 hasConcept C55493867 @default.
- W4385447832 hasConcept C86803240 @default.
- W4385447832 hasConcept C98274493 @default.
- W4385447832 hasConceptScore W4385447832C147990577 @default.
- W4385447832 hasConceptScore W4385447832C170493617 @default.
- W4385447832 hasConceptScore W4385447832C178790620 @default.
- W4385447832 hasConceptScore W4385447832C17991360 @default.
- W4385447832 hasConceptScore W4385447832C185592680 @default.
- W4385447832 hasConceptScore W4385447832C203014093 @default.
- W4385447832 hasConceptScore W4385447832C2776914184 @default.
- W4385447832 hasConceptScore W4385447832C2776997535 @default.
- W4385447832 hasConceptScore W4385447832C2777622882 @default.
- W4385447832 hasConceptScore W4385447832C519581460 @default.
- W4385447832 hasConceptScore W4385447832C55493867 @default.
- W4385447832 hasConceptScore W4385447832C86803240 @default.
- W4385447832 hasConceptScore W4385447832C98274493 @default.
- W4385447832 hasFunder F4320337111 @default.
- W4385447832 hasLocation W43854478321 @default.