Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385453897> ?p ?o ?g. }
- W4385453897 endingPage "102391" @default.
- W4385453897 startingPage "102391" @default.
- W4385453897 abstract "Mycobacteria enter host phagocytes, such as macrophages by binding to several receptors on phagocytes. Several mycobacterial species, including Mycobacterium tuberculosis have evolved systems to evade host bactericidal pathways. Lipoarabinomannan (LAM) is an essential mycobacterial molecule for both binding to phagocytes and escaping from bactericidal pathways. Integrin CD11b plays critical roles as a phagocytic receptor and contributes to host defense by mediating both nonopsonic and opsonic phagocytosis. However, the mechanisms by which CD11b-mediated phagocytosis associates with LAM and drives the phagocytic process of mycobacteria remain to be fully elucidated. We recently identified TMDU3 as anti-LAM IgM antibody against the mannan core of LAM. The present study investigated the roles of CD11b and TMDU3 in macrophage phagocytosis of mycobacteria and subsequent bactericidal lysosomal fusion to phagosomes. CD11b knockout cells generated by a CRISPR/Cas9 system showed significant attenuation of the ability to phagocytose non-opsonized mycobacteria and LAM-conjugated beads. Moreover, recombinant human CD11b protein was found to bind to LAM. TMDU3 markedly inhibited macrophage phagocytosis of non-opsonized mycobacteria. This antibody slightly increased the phagocytosis of mycobacteria under opsonized conditions, whereas it significantly enhanced CD11b-mediated bactericidal functions. Taken together, these results show a novel phylactic role of anti-LAM IgM during mycobacterial infection in macrophages." @default.
- W4385453897 created "2023-08-02" @default.
- W4385453897 creator A5005970936 @default.
- W4385453897 creator A5016322939 @default.
- W4385453897 creator A5040549451 @default.
- W4385453897 creator A5040919374 @default.
- W4385453897 creator A5044132578 @default.
- W4385453897 creator A5048504310 @default.
- W4385453897 creator A5049975826 @default.
- W4385453897 creator A5053633715 @default.
- W4385453897 date "2023-12-01" @default.
- W4385453897 modified "2023-10-15" @default.
- W4385453897 title "Phylactic role of anti-lipoarabinomannan IgM directed against mannan core during mycobacterial infection in macrophages" @default.
- W4385453897 cites W1532427044 @default.
- W4385453897 cites W1557707473 @default.
- W4385453897 cites W1579749431 @default.
- W4385453897 cites W1603982546 @default.
- W4385453897 cites W1642418561 @default.
- W4385453897 cites W1699226466 @default.
- W4385453897 cites W1820964911 @default.
- W4385453897 cites W1835941416 @default.
- W4385453897 cites W1867652495 @default.
- W4385453897 cites W1901576288 @default.
- W4385453897 cites W1926532709 @default.
- W4385453897 cites W1969734146 @default.
- W4385453897 cites W1973260880 @default.
- W4385453897 cites W1973761389 @default.
- W4385453897 cites W1974088684 @default.
- W4385453897 cites W1979035438 @default.
- W4385453897 cites W1987217273 @default.
- W4385453897 cites W1994685223 @default.
- W4385453897 cites W2012416622 @default.
- W4385453897 cites W2019978786 @default.
- W4385453897 cites W2021808259 @default.
- W4385453897 cites W2035011417 @default.
- W4385453897 cites W2038605458 @default.
- W4385453897 cites W2048009292 @default.
- W4385453897 cites W2057608834 @default.
- W4385453897 cites W2059159732 @default.
- W4385453897 cites W2076274573 @default.
- W4385453897 cites W2079374863 @default.
- W4385453897 cites W2081705655 @default.
- W4385453897 cites W2091008416 @default.
- W4385453897 cites W2093623361 @default.
- W4385453897 cites W2106204842 @default.
- W4385453897 cites W2107953671 @default.
- W4385453897 cites W2108864598 @default.
- W4385453897 cites W2113926700 @default.
- W4385453897 cites W2115240926 @default.
- W4385453897 cites W2119784689 @default.
- W4385453897 cites W2123036801 @default.
- W4385453897 cites W2123888778 @default.
- W4385453897 cites W2126426345 @default.
- W4385453897 cites W2131917465 @default.
- W4385453897 cites W2132252339 @default.
- W4385453897 cites W2133345063 @default.
- W4385453897 cites W2135069549 @default.
- W4385453897 cites W2137160819 @default.
- W4385453897 cites W2148928984 @default.
- W4385453897 cites W2152205479 @default.
- W4385453897 cites W2166886119 @default.
- W4385453897 cites W2167276755 @default.
- W4385453897 cites W2249750674 @default.
- W4385453897 cites W2327763024 @default.
- W4385453897 cites W2501401121 @default.
- W4385453897 cites W2512141013 @default.
- W4385453897 cites W2531028337 @default.
- W4385453897 cites W2739603833 @default.
- W4385453897 cites W2760814996 @default.
- W4385453897 cites W2884642332 @default.
- W4385453897 cites W2900023840 @default.
- W4385453897 cites W2999811208 @default.
- W4385453897 cites W3022935852 @default.
- W4385453897 cites W3130423531 @default.
- W4385453897 cites W3157093074 @default.
- W4385453897 cites W3204727699 @default.
- W4385453897 cites W3214923963 @default.
- W4385453897 cites W4205420957 @default.
- W4385453897 cites W4206995928 @default.
- W4385453897 cites W4210727511 @default.
- W4385453897 cites W4254661492 @default.
- W4385453897 doi "https://doi.org/10.1016/j.tube.2023.102391" @default.
- W4385453897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37574397" @default.
- W4385453897 hasPublicationYear "2023" @default.
- W4385453897 type Work @default.
- W4385453897 citedByCount "0" @default.
- W4385453897 crossrefType "journal-article" @default.
- W4385453897 hasAuthorship W4385453897A5005970936 @default.
- W4385453897 hasAuthorship W4385453897A5016322939 @default.
- W4385453897 hasAuthorship W4385453897A5040549451 @default.
- W4385453897 hasAuthorship W4385453897A5040919374 @default.
- W4385453897 hasAuthorship W4385453897A5044132578 @default.
- W4385453897 hasAuthorship W4385453897A5048504310 @default.
- W4385453897 hasAuthorship W4385453897A5049975826 @default.
- W4385453897 hasAuthorship W4385453897A5053633715 @default.
- W4385453897 hasBestOaLocation W43854538971 @default.
- W4385453897 hasConcept C100817775 @default.
- W4385453897 hasConcept C142724271 @default.