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- W4385454023 endingPage "112913" @default.
- W4385454023 startingPage "112913" @default.
- W4385454023 abstract "Pancreatic islets are endocrine organs that depend on their microvasculature to function. Along with endothelial cells, pericytes comprise the islet microvascular network. These mural cells are crucial for microvascular stability and function, but it is not known if/how they are affected during the development of type 1 diabetes (T1D). Here, we investigate islet pericyte density, phenotype, and function using living pancreas slices from donors without diabetes, donors with a single T1D-associated autoantibody (GADA+), and recent onset T1D cases. Our data show that islet pericyte and capillary responses to vasoactive stimuli are impaired early on in T1D. Microvascular dysfunction is associated with a switch in the phenotype of islet pericytes toward myofibroblasts. Using publicly available RNA sequencing (RNA-seq) data, we further found that transcriptional alterations related to endothelin-1 signaling and vascular and extracellular matrix (ECM) remodeling are hallmarks of single autoantibody (Aab)+ donor pancreata. Our data show that microvascular dysfunction is present at early stages of islet autoimmunity." @default.
- W4385454023 created "2023-08-02" @default.
- W4385454023 creator A5019552767 @default.
- W4385454023 creator A5028031113 @default.
- W4385454023 creator A5030460597 @default.
- W4385454023 creator A5039481939 @default.
- W4385454023 creator A5062682278 @default.
- W4385454023 creator A5089069741 @default.
- W4385454023 date "2023-08-01" @default.
- W4385454023 modified "2023-10-17" @default.
- W4385454023 title "Pericyte dysfunction and impaired vasomotion are hallmarks of islets during the pathogenesis of type 1 diabetes" @default.
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- W4385454023 doi "https://doi.org/10.1016/j.celrep.2023.112913" @default.