Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385454767> ?p ?o ?g. }
- W4385454767 endingPage "3909" @default.
- W4385454767 startingPage "3909" @default.
- W4385454767 abstract "Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been thoroughly explored. In this work, we aimed to characterize the mRNA and protein expression pattern of ACE2, TMPRSS2, and Furin in a series of patients with thyroid lesions. Our main results revealed a significantly decreased expression of ACE2 mRNA in the thyroid neoplasms in comparison to normal adjacent tissue. Furin mRNA was significantly increased in thyroid neoplasms when compared to normal adjacent tissue. In addition, a higher Furin mRNA level in thyroid carcinomas was associated with the presence of lymph node metastasis. Furin mRNA expression revealed a high discriminatory power between adjacent tissue and neoplasms. Protein expression of these molecules did not correlate with mRNA expression. Our study shows the mRNA downregulation of ACE2 and overexpression of Furin in thyroid neoplasms. Further studies are required to clarify if Furin expression can be a potential diagnostic indicator in thyroid neoplasia." @default.
- W4385454767 created "2023-08-02" @default.
- W4385454767 creator A5000031257 @default.
- W4385454767 creator A5017997346 @default.
- W4385454767 creator A5028938210 @default.
- W4385454767 creator A5053677994 @default.
- W4385454767 creator A5056063929 @default.
- W4385454767 creator A5063696842 @default.
- W4385454767 creator A5068217084 @default.
- W4385454767 creator A5078573061 @default.
- W4385454767 creator A5085594934 @default.
- W4385454767 date "2023-08-01" @default.
- W4385454767 modified "2023-09-30" @default.
- W4385454767 title "Significance of Furin Expression in Thyroid Neoplastic Transformation" @default.
- W4385454767 cites W1563019217 @default.
- W4385454767 cites W1675232888 @default.
- W4385454767 cites W1749453950 @default.
- W4385454767 cites W1885047062 @default.
- W4385454767 cites W1895719334 @default.
- W4385454767 cites W2000040025 @default.
- W4385454767 cites W2012034410 @default.
- W4385454767 cites W2016743182 @default.
- W4385454767 cites W2019232761 @default.
- W4385454767 cites W2024090372 @default.
- W4385454767 cites W2026772964 @default.
- W4385454767 cites W2046096315 @default.
- W4385454767 cites W2067521148 @default.
- W4385454767 cites W2087340528 @default.
- W4385454767 cites W2094222285 @default.
- W4385454767 cites W2105007263 @default.
- W4385454767 cites W2112825838 @default.
- W4385454767 cites W2122976061 @default.
- W4385454767 cites W2134872401 @default.
- W4385454767 cites W2161399617 @default.
- W4385454767 cites W2169170566 @default.
- W4385454767 cites W2281172928 @default.
- W4385454767 cites W2479891754 @default.
- W4385454767 cites W2605054024 @default.
- W4385454767 cites W2611699884 @default.
- W4385454767 cites W2779196251 @default.
- W4385454767 cites W2946455326 @default.
- W4385454767 cites W2982328611 @default.
- W4385454767 cites W2996024307 @default.
- W4385454767 cites W3008295344 @default.
- W4385454767 cites W3009912996 @default.
- W4385454767 cites W3010126769 @default.
- W4385454767 cites W3014816159 @default.
- W4385454767 cites W3019773443 @default.
- W4385454767 cites W3022550650 @default.
- W4385454767 cites W3036082737 @default.
- W4385454767 cites W3038741500 @default.
- W4385454767 cites W3041100686 @default.
- W4385454767 cites W3041269723 @default.
- W4385454767 cites W3042078222 @default.
- W4385454767 cites W3042426253 @default.
- W4385454767 cites W3043002108 @default.
- W4385454767 cites W3043762389 @default.
- W4385454767 cites W3044069820 @default.
- W4385454767 cites W3092573909 @default.
- W4385454767 cites W3095988184 @default.
- W4385454767 cites W3097074085 @default.
- W4385454767 cites W3108425280 @default.
- W4385454767 cites W3108487848 @default.
- W4385454767 cites W3118438588 @default.
- W4385454767 cites W3120888489 @default.
- W4385454767 cites W3128694351 @default.
- W4385454767 cites W3150635270 @default.
- W4385454767 cites W3158556950 @default.
- W4385454767 cites W3180407683 @default.
- W4385454767 cites W3184934265 @default.
- W4385454767 cites W3201758283 @default.
- W4385454767 cites W3203433659 @default.
- W4385454767 cites W4210665241 @default.
- W4385454767 cites W4224509106 @default.
- W4385454767 cites W4225249751 @default.
- W4385454767 cites W4281569547 @default.
- W4385454767 cites W4281763324 @default.
- W4385454767 cites W4283398756 @default.
- W4385454767 cites W4321165742 @default.
- W4385454767 doi "https://doi.org/10.3390/cancers15153909" @default.
- W4385454767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37568724" @default.
- W4385454767 hasPublicationYear "2023" @default.
- W4385454767 type Work @default.
- W4385454767 citedByCount "0" @default.
- W4385454767 crossrefType "journal-article" @default.
- W4385454767 hasAuthorship W4385454767A5000031257 @default.
- W4385454767 hasAuthorship W4385454767A5017997346 @default.
- W4385454767 hasAuthorship W4385454767A5028938210 @default.
- W4385454767 hasAuthorship W4385454767A5053677994 @default.
- W4385454767 hasAuthorship W4385454767A5056063929 @default.
- W4385454767 hasAuthorship W4385454767A5063696842 @default.
- W4385454767 hasAuthorship W4385454767A5068217084 @default.
- W4385454767 hasAuthorship W4385454767A5078573061 @default.
- W4385454767 hasAuthorship W4385454767A5085594934 @default.
- W4385454767 hasBestOaLocation W43854547671 @default.
- W4385454767 hasConcept C104317684 @default.
- W4385454767 hasConcept C105580179 @default.
- W4385454767 hasConcept C127561419 @default.