Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385455226> ?p ?o ?g. }
- W4385455226 endingPage "12287" @default.
- W4385455226 startingPage "12287" @default.
- W4385455226 abstract "Emerging evidence supports that altered α-tubulin acetylation occurs in Parkinson's disease (PD), a neurodegenerative disorder characterized by the deposition of α-synuclein fibrillary aggregates within Lewy bodies and nigrostriatal neuron degeneration. Nevertheless, studies addressing the interplay between α-tubulin acetylation and α-synuclein are lacking. Here, we investigated the relationship between α-synuclein and microtubules in primary midbrain murine neurons and the substantia nigra of post-mortem human brains. Taking advantage of immunofluorescence and Proximity Ligation Assay (PLA), a method allowing us to visualize protein-protein interactions in situ, combined with confocal and super-resolution microscopy, we found that α-synuclein and acetylated α-tubulin colocalized and were in close proximity. Next, we employed an α-synuclein overexpressing cellular model and tested the role of α-tubulin acetylation in α-synuclein oligomer formation. We used the α-tubulin deacetylase HDAC6 inhibitor Tubacin to modulate α-tubulin acetylation, and we evaluated the presence of α-synuclein oligomers by PLA. We found that the increase in acetylated α-tubulin significantly induced α-synuclein oligomerization. In conclusion, we unraveled the link between acetylated α-tubulin and α-synuclein and demonstrated that α-tubulin acetylation could trigger the early step of α-synuclein aggregation. These data suggest that the proper regulation of α-tubulin acetylation might be considered a therapeutic strategy to take on PD." @default.
- W4385455226 created "2023-08-02" @default.
- W4385455226 creator A5010729201 @default.
- W4385455226 creator A5012729392 @default.
- W4385455226 creator A5022867844 @default.
- W4385455226 creator A5023721480 @default.
- W4385455226 creator A5045781933 @default.
- W4385455226 creator A5060392442 @default.
- W4385455226 creator A5063552454 @default.
- W4385455226 creator A5079745354 @default.
- W4385455226 creator A5087554551 @default.
- W4385455226 date "2023-07-31" @default.
- W4385455226 modified "2023-09-30" @default.
- W4385455226 title "Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization" @default.
- W4385455226 cites W1023820744 @default.
- W4385455226 cites W1480539518 @default.
- W4385455226 cites W1486762479 @default.
- W4385455226 cites W1527671059 @default.
- W4385455226 cites W1574848178 @default.
- W4385455226 cites W191741448 @default.
- W4385455226 cites W1965404941 @default.
- W4385455226 cites W1966086525 @default.
- W4385455226 cites W1969529487 @default.
- W4385455226 cites W1987331847 @default.
- W4385455226 cites W1989730458 @default.
- W4385455226 cites W1992496728 @default.
- W4385455226 cites W2003303711 @default.
- W4385455226 cites W2019050557 @default.
- W4385455226 cites W2024449044 @default.
- W4385455226 cites W2026412511 @default.
- W4385455226 cites W2029742652 @default.
- W4385455226 cites W2034859720 @default.
- W4385455226 cites W2035251029 @default.
- W4385455226 cites W2039073478 @default.
- W4385455226 cites W2039919932 @default.
- W4385455226 cites W2040462263 @default.
- W4385455226 cites W2048741943 @default.
- W4385455226 cites W2059261643 @default.
- W4385455226 cites W2064959533 @default.
- W4385455226 cites W2066322915 @default.
- W4385455226 cites W2089393338 @default.
- W4385455226 cites W2090926709 @default.
- W4385455226 cites W2136977743 @default.
- W4385455226 cites W2140067811 @default.
- W4385455226 cites W2153789584 @default.
- W4385455226 cites W2157617823 @default.
- W4385455226 cites W2161334375 @default.
- W4385455226 cites W2329808372 @default.
- W4385455226 cites W2417670847 @default.
- W4385455226 cites W2436282489 @default.
- W4385455226 cites W2482664294 @default.
- W4385455226 cites W2520733374 @default.
- W4385455226 cites W2547265118 @default.
- W4385455226 cites W2561022367 @default.
- W4385455226 cites W2577340531 @default.
- W4385455226 cites W2591669685 @default.
- W4385455226 cites W2593043086 @default.
- W4385455226 cites W2606253816 @default.
- W4385455226 cites W2621339407 @default.
- W4385455226 cites W2745164635 @default.
- W4385455226 cites W2754450620 @default.
- W4385455226 cites W2755148565 @default.
- W4385455226 cites W2770574196 @default.
- W4385455226 cites W2775514330 @default.
- W4385455226 cites W2898559606 @default.
- W4385455226 cites W2909456234 @default.
- W4385455226 cites W2913772728 @default.
- W4385455226 cites W2914531086 @default.
- W4385455226 cites W2953014442 @default.
- W4385455226 cites W2956103188 @default.
- W4385455226 cites W2968620770 @default.
- W4385455226 cites W2982334477 @default.
- W4385455226 cites W3005954616 @default.
- W4385455226 cites W3036545297 @default.
- W4385455226 cites W3045334142 @default.
- W4385455226 cites W3047605799 @default.
- W4385455226 cites W3082405219 @default.
- W4385455226 cites W3086585072 @default.
- W4385455226 cites W3156273102 @default.
- W4385455226 cites W3169544636 @default.
- W4385455226 cites W3186540326 @default.
- W4385455226 cites W3195738414 @default.
- W4385455226 cites W4210664367 @default.
- W4385455226 cites W4289204872 @default.
- W4385455226 cites W4304892707 @default.
- W4385455226 cites W4313423334 @default.
- W4385455226 cites W4362692584 @default.
- W4385455226 cites W4375856263 @default.
- W4385455226 doi "https://doi.org/10.3390/ijms241512287" @default.
- W4385455226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37569662" @default.
- W4385455226 hasPublicationYear "2023" @default.
- W4385455226 type Work @default.
- W4385455226 citedByCount "0" @default.
- W4385455226 crossrefType "journal-article" @default.
- W4385455226 hasAuthorship W4385455226A5010729201 @default.
- W4385455226 hasAuthorship W4385455226A5012729392 @default.
- W4385455226 hasAuthorship W4385455226A5022867844 @default.
- W4385455226 hasAuthorship W4385455226A5023721480 @default.