FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385455371> ?p ?o ?g. }

• W4385455371 endingPage "1202" @default.
• W4385455371 startingPage "1202" @default.
• W4385455371 abstract "In respiring mitochondria, the proton gradient across the inner mitochondrial membrane is used to drive ATP production. Mitochondrial uncouplers, which are typically weak acid protonophores, can disrupt this process to induce mitochondrial dysfunction and apoptosis in cancer cells. We have shown that bisaryl urea-based anion transporters can also mediate mitochondrial uncoupling through a novel fatty acid-activated proton transport mechanism, where the bisaryl urea promotes the transbilayer movement of deprotonated fatty acids and proton transport. In this paper, we investigated the impact of replacing the urea group with squaramide, amide and diurea anion binding motifs. Bisaryl squaramides were found to depolarise mitochondria and reduce MDA-MB-231 breast cancer cell viability to similar extents as their urea counterpart. Bisaryl amides and diureas were less active and required higher concentrations to produce these effects. For all scaffolds, the substitution of the bisaryl rings with lipophilic electron-withdrawing groups was required for activity. An investigation of the proton transport mechanism in vesicles showed that active compounds participate in fatty acid-activated proton transport, except for a squaramide analogue, which was sufficiently acidic to act as a classical protonophore and transport protons in the absence of free fatty acids." @default.
• W4385455371 created "2023-08-02" @default.
• W4385455371 creator A5007474183 @default.
• W4385455371 creator A5011013044 @default.
• W4385455371 creator A5018131137 @default.
• W4385455371 creator A5071497406 @default.
• W4385455371 creator A5088381100 @default.
• W4385455371 date "2023-07-31" @default.
• W4385455371 modified "2023-09-25" @default.
• W4385455371 title "Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells" @default.
• W4385455371 cites W1484126258 @default.
• W4385455371 cites W1990758117 @default.
• W4385455371 cites W1992037085 @default.
• W4385455371 cites W1997095280 @default.
• W4385455371 cites W2024191422 @default.
• W4385455371 cites W2044537004 @default.
• W4385455371 cites W2053875039 @default.
• W4385455371 cites W2081333152 @default.
• W4385455371 cites W2105744572 @default.
• W4385455371 cites W2108733419 @default.
• W4385455371 cites W2115232419 @default.
• W4385455371 cites W2140039202 @default.
• W4385455371 cites W2144277227 @default.
• W4385455371 cites W2151979023 @default.
• W4385455371 cites W2155882055 @default.
• W4385455371 cites W2560672271 @default.
• W4385455371 cites W2768461509 @default.
• W4385455371 cites W2784941139 @default.
• W4385455371 cites W2811255263 @default.
• W4385455371 cites W2905473823 @default.
• W4385455371 cites W2946765204 @default.
• W4385455371 cites W2951929336 @default.
• W4385455371 cites W2954627321 @default.
• W4385455371 cites W3044481239 @default.
• W4385455371 cites W3150711058 @default.
• W4385455371 cites W3216825931 @default.
• W4385455371 cites W3217549051 @default.
• W4385455371 cites W4286212769 @default.
• W4385455371 cites W4308537760 @default.
• W4385455371 doi "https://doi.org/10.3390/biom13081202" @default.
• W4385455371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37627266" @default.
• W4385455371 hasPublicationYear "2023" @default.
• W4385455371 type Work @default.
• W4385455371 citedByCount "0" @default.
• W4385455371 crossrefType "journal-article" @default.
• W4385455371 hasAuthorship W4385455371A5007474183 @default.
• W4385455371 hasAuthorship W4385455371A5011013044 @default.
• W4385455371 hasAuthorship W4385455371A5018131137 @default.
• W4385455371 hasAuthorship W4385455371A5071497406 @default.
• W4385455371 hasAuthorship W4385455371A5088381100 @default.
• W4385455371 hasBestOaLocation W43854553711 @default.
• W4385455371 hasConcept C112243037 @default.
• W4385455371 hasConcept C121608353 @default.
• W4385455371 hasConcept C12554922 @default.
• W4385455371 hasConcept C171357686 @default.
• W4385455371 hasConcept C181199279 @default.
• W4385455371 hasConcept C181911157 @default.
• W4385455371 hasConcept C185592680 @default.
• W4385455371 hasConcept C24840226 @default.
• W4385455371 hasConcept C2780365088 @default.
• W4385455371 hasConcept C2780397019 @default.
• W4385455371 hasConcept C28859421 @default.
• W4385455371 hasConcept C2992012372 @default.
• W4385455371 hasConcept C41625074 @default.
• W4385455371 hasConcept C543025807 @default.
• W4385455371 hasConcept C54355233 @default.
• W4385455371 hasConcept C55493867 @default.
• W4385455371 hasConcept C57181701 @default.
• W4385455371 hasConcept C75385678 @default.
• W4385455371 hasConcept C86803240 @default.
• W4385455371 hasConcept C90424259 @default.
• W4385455371 hasConcept C96232424 @default.
• W4385455371 hasConceptScore W4385455371C112243037 @default.
• W4385455371 hasConceptScore W4385455371C121608353 @default.
• W4385455371 hasConceptScore W4385455371C12554922 @default.
• W4385455371 hasConceptScore W4385455371C171357686 @default.
• W4385455371 hasConceptScore W4385455371C181199279 @default.
• W4385455371 hasConceptScore W4385455371C181911157 @default.
• W4385455371 hasConceptScore W4385455371C185592680 @default.
• W4385455371 hasConceptScore W4385455371C24840226 @default.
• W4385455371 hasConceptScore W4385455371C2780365088 @default.
• W4385455371 hasConceptScore W4385455371C2780397019 @default.
• W4385455371 hasConceptScore W4385455371C28859421 @default.
• W4385455371 hasConceptScore W4385455371C2992012372 @default.
• W4385455371 hasConceptScore W4385455371C41625074 @default.
• W4385455371 hasConceptScore W4385455371C543025807 @default.
• W4385455371 hasConceptScore W4385455371C54355233 @default.
• W4385455371 hasConceptScore W4385455371C55493867 @default.
• W4385455371 hasConceptScore W4385455371C57181701 @default.
• W4385455371 hasConceptScore W4385455371C75385678 @default.
• W4385455371 hasConceptScore W4385455371C86803240 @default.
• W4385455371 hasConceptScore W4385455371C90424259 @default.
• W4385455371 hasConceptScore W4385455371C96232424 @default.
• W4385455371 hasFunder F4320334704 @default.
• W4385455371 hasIssue "8" @default.
• W4385455371 hasLocation W43854553711 @default.
• W4385455371 hasLocation W43854553712 @default.
• W4385455371 hasOpenAccess W4385455371 @default.

• next