FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385455729> ?p ?o ?g. }

• W4385455729 endingPage "918" @default.
• W4385455729 startingPage "918" @default.
• W4385455729 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> The risk of recurrence after nephrectomy for primary clear cell renal cell carcinoma (ccRCC) is estimated in daily practice solely based on clinical criteria. The aim of this study was to assess the prognostic relevance of common somatic mutations with respect to tumor aggressiveness and outcomes of ccRCC patients after definitive treatment.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> Primary tumors from 37 patients with ccRCC who underwent radical nephrectomy were analyzed for presence of somatic mutations using a 15-gene targeted next-generation sequencing (NGS) panel. Associations to histopathologic characteristics and outcomes were investigated in the study cohort (n=37) and validated in The Cancer Genome Atlas (TCGA) ccRCC cohort (n=451).</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> <ns4:italic>VHL</ns4:italic> was the most frequently mutated gene (51%), followed by <ns4:italic>PBRM1</ns4:italic> (27%), <ns4:italic>BAP1</ns4:italic> (13%), <ns4:italic>SETD2</ns4:italic> (13%), <ns4:italic>KDM5C </ns4:italic>(5%), <ns4:italic>ATM </ns4:italic>(5%), <ns4:italic>MTOR</ns4:italic> (5%), and <ns4:italic>PTEN</ns4:italic> (3%). One-third of patients did not have any somatic mutations within the 15-gene panel. The vast majority of tumors harboring no mutations at all or VHL-only mutations (51%) were more frequently of smaller size (pT1-2) and earlier stage (I/II), whereas presence of any other gene mutations in various combinations with or without <ns4:italic>VHL</ns4:italic> was enriched in larger (pT3) and higher stage tumors (III) (p=0.02). No recurrences were noted in patients with unmutated tumors or <ns4:italic>VHL</ns4:italic>-only mutations as opposed to three relapses in patients with non-<ns4:italic>VHL</ns4:italic> somatic mutations (p=0.06). Presence of somatic mutations in <ns4:italic>PBRM1, BAP1, SETD2, KDM5C, ATM, MTOR</ns4:italic>, or <ns4:italic>PTEN</ns4:italic> genes in 451 TCGA ccRCC patients was associated with a significantly shorter disease-free survival (DFS) compared to those with unaltered tumors (q=0.01).</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> Preliminary findings from this ongoing study support the prognostic value of non-<ns4:italic>VHL</ns4:italic> mutations including <ns4:italic>PBRM1, BAP1, SETD2, KDM5C, ATM, MTOR</ns4:italic>, and <ns4:italic>PTEN</ns4:italic> in primary ccRCC tumors as surrogates of earlier recurrence and potential selection for adjuvant immune checkpoint inhibition.</ns4:p>" @default.
• W4385455729 created "2023-08-02" @default.
• W4385455729 creator A5001990005 @default.
• W4385455729 creator A5027528008 @default.
• W4385455729 creator A5029399613 @default.
• W4385455729 creator A5052517445 @default.
• W4385455729 creator A5053215757 @default.
• W4385455729 creator A5060046727 @default.
• W4385455729 creator A5061020970 @default.
• W4385455729 creator A5070913971 @default.
• W4385455729 creator A5073818624 @default.
• W4385455729 creator A5074156910 @default.
• W4385455729 creator A5084671317 @default.
• W4385455729 date "2023-08-01" @default.
• W4385455729 modified "2023-10-18" @default.
• W4385455729 title "Mutational profile of primary clear cell renal cell carcinoma predicts recurrence and potential candidacy for adjuvant immune checkpoint inhibition" @default.
• W4385455729 cites W1520140649 @default.
• W4385455729 cites W1871307580 @default.
• W4385455729 cites W1969112349 @default.
• W4385455729 cites W2064072638 @default.
• W4385455729 cites W2069480574 @default.
• W4385455729 cites W2092892924 @default.
• W4385455729 cites W2152874907 @default.
• W4385455729 cites W2158290434 @default.
• W4385455729 cites W2327979780 @default.
• W4385455729 cites W2335012284 @default.
• W4385455729 cites W2726542547 @default.
• W4385455729 cites W2727707426 @default.
• W4385455729 cites W2884688694 @default.
• W4385455729 cites W2889646458 @default.
• W4385455729 cites W2949246094 @default.
• W4385455729 cites W3085054995 @default.
• W4385455729 cites W3137607139 @default.
• W4385455729 cites W3196207248 @default.
• W4385455729 cites W4294358748 @default.
• W4385455729 cites W4312129827 @default.
• W4385455729 cites W4321459593 @default.
• W4385455729 doi "https://doi.org/10.12688/f1000research.136087.1" @default.
• W4385455729 hasPublicationYear "2023" @default.
• W4385455729 type Work @default.
• W4385455729 citedByCount "0" @default.
• W4385455729 crossrefType "journal-article" @default.
• W4385455729 hasAuthorship W4385455729A5001990005 @default.
• W4385455729 hasAuthorship W4385455729A5027528008 @default.
• W4385455729 hasAuthorship W4385455729A5029399613 @default.
• W4385455729 hasAuthorship W4385455729A5052517445 @default.
• W4385455729 hasAuthorship W4385455729A5053215757 @default.
• W4385455729 hasAuthorship W4385455729A5060046727 @default.
• W4385455729 hasAuthorship W4385455729A5061020970 @default.
• W4385455729 hasAuthorship W4385455729A5070913971 @default.
• W4385455729 hasAuthorship W4385455729A5073818624 @default.
• W4385455729 hasAuthorship W4385455729A5074156910 @default.
• W4385455729 hasAuthorship W4385455729A5084671317 @default.
• W4385455729 hasBestOaLocation W43854557291 @default.
• W4385455729 hasConcept C86803240 @default.
• W4385455729 hasConceptScore W4385455729C86803240 @default.
• W4385455729 hasLocation W43854557291 @default.
• W4385455729 hasOpenAccess W4385455729 @default.
• W4385455729 hasPrimaryLocation W43854557291 @default.
• W4385455729 hasRelatedWork W1641042124 @default.
• W4385455729 hasRelatedWork W1990804418 @default.
• W4385455729 hasRelatedWork W1993764875 @default.
• W4385455729 hasRelatedWork W2013243191 @default.
• W4385455729 hasRelatedWork W2051339581 @default.
• W4385455729 hasRelatedWork W2082860237 @default.
• W4385455729 hasRelatedWork W2117258802 @default.
• W4385455729 hasRelatedWork W2130076355 @default.
• W4385455729 hasRelatedWork W2151865869 @default.
• W4385455729 hasRelatedWork W4234157524 @default.
• W4385455729 hasVolume "12" @default.
• W4385455729 isParatext "false" @default.
• W4385455729 isRetracted "false" @default.
• W4385455729 workType "article" @default.