FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385459688> ?p ?o ?g. }

• W4385459688 abstract "Abstract Background Multiplex molecular diagnostic panels have greatly enhanced detection of gastrointestinal pathogens. However, data on the impact of these tests on clinical and patient-centered outcomes are limited. Methods We conducted a prospective, multicenter, stepped-wedge trial to determine the impact of multiplex molecular testing at five academic children’s hospitals in children presenting to the ED with acute gastroenteritis. Caregivers were interviewed on enrollment and again 7-10 days after enrollment to determine symptoms, risk factors, subsequent medical visits, and impact on family members. During the pre-intervention period, diagnostic testing was performed at the discretion of clinicians. During the intervention period, multiplex molecular testing was performed on all children with results available to clinicians. Primary outcome was return visits to a health care provider within 10 days of enrollment. Results Potential pathogens were identified by clinician ordered tests in 19/571 (3.3%) in the pre-intervention period compared to 434/586 (74%) in the intervention period; clinically relevant pathogens were detected in 2.1% and 15% respectively. In the multivariate model adjusting for potential confounders, the intervention was associated with a 21% reduction in the odds of any return visit (OR 0.79; 95% CI 0.70-0.90). Appropriate treatment was prescribed in 11.3% compared to 19.6% during the intervention period(P=0.22). Conclusions Routine molecular multiplex testing for all children presenting to the ED with AGE detected more clinically relevant pathogens and led to a 21% decrease in return visits. Additional research is needed to define patients most likely to benefit from testing." @default.
• W4385459688 created "2023-08-02" @default.
• W4385459688 creator A5006721425 @default.
• W4385459688 creator A5007787858 @default.
• W4385459688 creator A5011857175 @default.
• W4385459688 creator A5013863197 @default.
• W4385459688 creator A5021328151 @default.
• W4385459688 creator A5022029315 @default.
• W4385459688 creator A5040819299 @default.
• W4385459688 creator A5041988310 @default.
• W4385459688 creator A5046600133 @default.
• W4385459688 creator A5053267770 @default.
• W4385459688 creator A5054246877 @default.
• W4385459688 creator A5057483665 @default.
• W4385459688 creator A5057640390 @default.
• W4385459688 creator A5069468599 @default.
• W4385459688 creator A5073240820 @default.
• W4385459688 creator A5074497229 @default.
• W4385459688 creator A5074820741 @default.
• W4385459688 creator A5076594462 @default.
• W4385459688 creator A5090573532 @default.
• W4385459688 date "2023-07-31" @default.
• W4385459688 modified "2023-09-27" @default.
• W4385459688 title "Clinical Impact of Multiplex Molecular Diagnostic Testing in Children with Acute Gastroenteritis Presenting to An Emergency Department: A Multicenter Prospective Study" @default.
• W4385459688 cites W1769509752 @default.
• W4385459688 cites W1964488741 @default.
• W4385459688 cites W1978136073 @default.
• W4385459688 cites W1990838215 @default.
• W4385459688 cites W2018502278 @default.
• W4385459688 cites W2114053580 @default.
• W4385459688 cites W2118665460 @default.
• W4385459688 cites W2137535087 @default.
• W4385459688 cites W2147956812 @default.
• W4385459688 cites W2169792847 @default.
• W4385459688 cites W2346122755 @default.
• W4385459688 cites W2434350716 @default.
• W4385459688 cites W2566190515 @default.
• W4385459688 cites W2607433463 @default.
• W4385459688 cites W2734856741 @default.
• W4385459688 cites W2766880701 @default.
• W4385459688 cites W2800001604 @default.
• W4385459688 cites W2891808294 @default.
• W4385459688 cites W2902748048 @default.
• W4385459688 cites W2911200751 @default.
• W4385459688 cites W2971558661 @default.
• W4385459688 cites W3046218820 @default.
• W4385459688 cites W3092131298 @default.
• W4385459688 cites W3118826145 @default.
• W4385459688 cites W3142340917 @default.
• W4385459688 cites W3146855065 @default.
• W4385459688 cites W4293457661 @default.
• W4385459688 cites W4322616567 @default.
• W4385459688 cites W4366977725 @default.
• W4385459688 doi "https://doi.org/10.1101/2023.07.27.23293208" @default.
• W4385459688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37577483" @default.
• W4385459688 hasPublicationYear "2023" @default.
• W4385459688 type Work @default.
• W4385459688 citedByCount "0" @default.
• W4385459688 crossrefType "posted-content" @default.
• W4385459688 hasAuthorship W4385459688A5006721425 @default.
• W4385459688 hasAuthorship W4385459688A5007787858 @default.
• W4385459688 hasAuthorship W4385459688A5011857175 @default.
• W4385459688 hasAuthorship W4385459688A5013863197 @default.
• W4385459688 hasAuthorship W4385459688A5021328151 @default.
• W4385459688 hasAuthorship W4385459688A5022029315 @default.
• W4385459688 hasAuthorship W4385459688A5040819299 @default.
• W4385459688 hasAuthorship W4385459688A5041988310 @default.
• W4385459688 hasAuthorship W4385459688A5046600133 @default.
• W4385459688 hasAuthorship W4385459688A5053267770 @default.
• W4385459688 hasAuthorship W4385459688A5054246877 @default.
• W4385459688 hasAuthorship W4385459688A5057483665 @default.
• W4385459688 hasAuthorship W4385459688A5057640390 @default.
• W4385459688 hasAuthorship W4385459688A5069468599 @default.
• W4385459688 hasAuthorship W4385459688A5073240820 @default.
• W4385459688 hasAuthorship W4385459688A5074497229 @default.
• W4385459688 hasAuthorship W4385459688A5074820741 @default.
• W4385459688 hasAuthorship W4385459688A5076594462 @default.
• W4385459688 hasAuthorship W4385459688A5090573532 @default.
• W4385459688 hasBestOaLocation W43854596881 @default.
• W4385459688 hasConcept C118552586 @default.
• W4385459688 hasConcept C126322002 @default.
• W4385459688 hasConcept C156957248 @default.
• W4385459688 hasConcept C160735492 @default.
• W4385459688 hasConcept C162324750 @default.
• W4385459688 hasConcept C187212893 @default.
• W4385459688 hasConcept C188816634 @default.
• W4385459688 hasConcept C194828623 @default.
• W4385459688 hasConcept C27415008 @default.
• W4385459688 hasConcept C2780665704 @default.
• W4385459688 hasConcept C2780724011 @default.
• W4385459688 hasConcept C2781188995 @default.
• W4385459688 hasConcept C2781385661 @default.
• W4385459688 hasConcept C2993801374 @default.
• W4385459688 hasConcept C38180746 @default.
• W4385459688 hasConcept C50522688 @default.
• W4385459688 hasConcept C60644358 @default.
• W4385459688 hasConcept C71924100 @default.
• W4385459688 hasConcept C77350462 @default.
• W4385459688 hasConcept C86803240 @default.
• W4385459688 hasConceptScore W4385459688C118552586 @default.

• next