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• W4385461437 endingPage "125020" @default.
• W4385461437 startingPage "125020" @default.
• W4385461437 abstract "Robust and sensitive methods for the detection of microRNAs (miRNAs) are crucial in the clinical diagnosis of cancers. In this study, a novel electrochemical biosensor with high sensitivity for miRNA-21 detection is developed, which relies on the formation of a peptide nucleic acid (PNA)-DNA hetero-three-way junction (H3WJ) and target-recycling catalytic hairpin assembly (CHA) amplification. The electroneutral PNA probes are initially immobilized onto a gold electrode to construct the sensor. Upon introduction of miRNA-21, target-recycling CHA is initiated, resulting in abundant double-stranded CHA products. Subsequently, association between the PNA probes and these products leads to the formation of PNA-DNA H3WJs. Consequently, the electrode surface is densely populated with numerous electroactive Ferrocene (Fc) groups, resulting in a significantly amplified current response for highly sensitive detection of miRNA-21 at concentrations as low as 0.15 fM. This approach demonstrates remarkable specificity towards target miRNAs and can be utilized for quantitative monitoring of miRNA-21 expression in human cancer cells. More importantly, the sensor exhibits exceptional stability and shows a significant reduction in background noise during miRNA detection, making this method a highly promising sensing platform for monitoring various miRNA biomarkers to facilitate the diagnosis of diverse cancers." @default.
• W4385461437 created "2023-08-02" @default.
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• W4385461437 date "2024-01-01" @default.
• W4385461437 modified "2023-09-27" @default.
• W4385461437 title "A highly sensitive and robust electrochemical biosensor for microRNA detection based on PNA-DNA hetero-three-way junction formation and target-recycling catalytic hairpin assembly amplification" @default.
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• W4385461437 doi "https://doi.org/10.1016/j.talanta.2023.125020" @default.
• W4385461437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37541007" @default.
• W4385461437 hasPublicationYear "2024" @default.
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