FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385462242> ?p ?o ?g. }

• W4385462242 abstract "Abstract The UK Biobank is a large cohort study that recruited over 500,000 British participants aged 40-69 in 2006-2010 at 22 assessment centres from across the UK. Self-reported health outcomes and hospital admission data are two types of records that include participants’ disease status. Coronary artery disease (CAD) is the most common cause of death in the UK Biobank cohort. After distinguishing between prevalence and incidence CAD events for all UK Biobank participants, we identified geographical variations in age-standardised rates of CAD between assessment centres. Significant distributional differences were found between the pooled cohort equation scores of UK Biobank participants from England and Scotland using the Mann-Whitney test. Polygenic risk scores of UK Biobank participants from England and Scotland and from different assessment centres differed significantly using permutation tests. Our aim was to discriminate between assessment centres with different disease rates by collecting data on disease-related risk factors. However, relying solely on individual-level predictions and averaging them to obtain group-level predictions proved ineffective, particularly due to the presence of correlated covariates resulting from participation bias. By using the Mundlak model, which estimates a random effects regression by including the group means of the independent variables in the model, we effectively addressed these issues. In addition, we designed a simulation experiment to demonstrate the functionality of the Mundlak model. Our findings have applications in public health funding and strategy, as our approach can be used to predict case rates in the future, as both population structure and lifestyle changes are uncertain." @default.
• W4385462242 created "2023-08-02" @default.
• W4385462242 creator A5036608419 @default.
• W4385462242 creator A5069205785 @default.
• W4385462242 creator A5074023396 @default.
• W4385462242 date "2023-08-01" @default.
• W4385462242 modified "2023-09-27" @default.
• W4385462242 title "How group structure impacts the numbers at risk for coronary artery disease: polygenic risk scores and non-genetic risk factors in the UK Biobank cohort" @default.
• W4385462242 cites W1495037751 @default.
• W4385462242 cites W1968893448 @default.
• W4385462242 cites W1984513597 @default.
• W4385462242 cites W1993849688 @default.
• W4385462242 cites W2013458397 @default.
• W4385462242 cites W2035841117 @default.
• W4385462242 cites W2046481462 @default.
• W4385462242 cites W2082704080 @default.
• W4385462242 cites W2096451472 @default.
• W4385462242 cites W2097087816 @default.
• W4385462242 cites W2099085143 @default.
• W4385462242 cites W2117200996 @default.
• W4385462242 cites W2117594039 @default.
• W4385462242 cites W2118248224 @default.
• W4385462242 cites W2147773878 @default.
• W4385462242 cites W2147823464 @default.
• W4385462242 cites W2148092884 @default.
• W4385462242 cites W2168536722 @default.
• W4385462242 cites W2169795969 @default.
• W4385462242 cites W2188172595 @default.
• W4385462242 cites W2230691757 @default.
• W4385462242 cites W2516998275 @default.
• W4385462242 cites W2520572981 @default.
• W4385462242 cites W2527260951 @default.
• W4385462242 cites W2597132418 @default.
• W4385462242 cites W2613151407 @default.
• W4385462242 cites W2618596952 @default.
• W4385462242 cites W2723723801 @default.
• W4385462242 cites W2725988230 @default.
• W4385462242 cites W2755395050 @default.
• W4385462242 cites W2794694102 @default.
• W4385462242 cites W2895486342 @default.
• W4385462242 cites W2923291095 @default.
• W4385462242 cites W2951553270 @default.
• W4385462242 cites W2959924472 @default.
• W4385462242 cites W2963160524 @default.
• W4385462242 cites W2982517534 @default.
• W4385462242 cites W3007698544 @default.
• W4385462242 cites W3025794503 @default.
• W4385462242 cites W3045441625 @default.
• W4385462242 cites W3186034872 @default.
• W4385462242 cites W3215204751 @default.
• W4385462242 cites W3216077891 @default.
• W4385462242 cites W4200249631 @default.
• W4385462242 cites W4210669538 @default.
• W4385462242 cites W4223932267 @default.
• W4385462242 cites W4236673002 @default.
• W4385462242 cites W4283016062 @default.
• W4385462242 cites W4283067507 @default.
• W4385462242 cites W4284682103 @default.
• W4385462242 cites W4285098606 @default.
• W4385462242 cites W4304191665 @default.
• W4385462242 cites W4306643546 @default.
• W4385462242 cites W4321373070 @default.
• W4385462242 cites W4362666517 @default.
• W4385462242 cites W4367294547 @default.
• W4385462242 cites W4376616333 @default.
• W4385462242 doi "https://doi.org/10.1101/2023.07.28.23292953" @default.
• W4385462242 hasPublicationYear "2023" @default.
• W4385462242 type Work @default.
• W4385462242 citedByCount "0" @default.
• W4385462242 crossrefType "posted-content" @default.
• W4385462242 hasAuthorship W4385462242A5036608419 @default.
• W4385462242 hasAuthorship W4385462242A5069205785 @default.
• W4385462242 hasAuthorship W4385462242A5074023396 @default.
• W4385462242 hasBestOaLocation W43854622421 @default.
• W4385462242 hasConcept C116567970 @default.
• W4385462242 hasConcept C12174686 @default.
• W4385462242 hasConcept C126322002 @default.
• W4385462242 hasConcept C144024400 @default.
• W4385462242 hasConcept C149923435 @default.
• W4385462242 hasConcept C201903717 @default.
• W4385462242 hasConcept C2778213512 @default.
• W4385462242 hasConcept C2779134260 @default.
• W4385462242 hasConcept C2908647359 @default.
• W4385462242 hasConcept C38652104 @default.
• W4385462242 hasConcept C41008148 @default.
• W4385462242 hasConcept C60644358 @default.
• W4385462242 hasConcept C71924100 @default.
• W4385462242 hasConcept C72563966 @default.
• W4385462242 hasConcept C74909509 @default.
• W4385462242 hasConcept C86803240 @default.
• W4385462242 hasConcept C99454951 @default.
• W4385462242 hasConceptScore W4385462242C116567970 @default.
• W4385462242 hasConceptScore W4385462242C12174686 @default.
• W4385462242 hasConceptScore W4385462242C126322002 @default.
• W4385462242 hasConceptScore W4385462242C144024400 @default.
• W4385462242 hasConceptScore W4385462242C149923435 @default.
• W4385462242 hasConceptScore W4385462242C201903717 @default.
• W4385462242 hasConceptScore W4385462242C2778213512 @default.
• W4385462242 hasConceptScore W4385462242C2779134260 @default.
• W4385462242 hasConceptScore W4385462242C2908647359 @default.

• next