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- W4385466669 endingPage "889" @default.
- W4385466669 startingPage "873" @default.
- W4385466669 abstract "Invasive electrophysiology in humans has historically been possible under very constrained conditions in a small number of individuals. People with epilepsy may undergo intracranial monitoring, during which iEEG electrodes are temporarily implanted to localize seizure foci. The intraoperative environment also provides an opportunity for acute recordings of human neurophysiology. The advent of chronically implanted neurostimulation devices capable of sense and stimulation (“bidirectional”) has provided a window into human neurophysiology not previously attainable. Such devices are most commonly used to treat patients with epilepsy, Parkinson’s Disease, and essential tremor, with many other indications under active study. However, the neural recordings during daily life afforded by these devices allows for the discovery of biomarkers, or neural activity correlates, of physiological and pathological functions. Furthermore, the longitudinal nature of these recordings can provide new insight into the stability or lack thereof of these biomarkers. Here, we describe the devices available for such biomarker discovery, how biomarkers recorded using these devices can be used for research of physiological and disease states, provide example experimental workflows, and finally discuss the technological and practical limitations of currently available devices, as well as our projection of what research will be enabled by the next generation of devices." @default.
- W4385466669 created "2023-08-02" @default.
- W4385466669 creator A5016875112 @default.
- W4385466669 creator A5091099837 @default.
- W4385466669 date "2023-01-01" @default.
- W4385466669 modified "2023-09-23" @default.
- W4385466669 title "Can Chronically Implanted iEEG Sense and Stimulation Devices Accelerate the Discovery of Neural Biomarkers?" @default.
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