Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385469215> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4385469215 abstract "Abstract Background The role of cytoreductive local radiotherapy (RT) in metastatic prostate cancer has recently been established. This study aimed to evaluate the biochemical outcome of local RT in metastatic prostate cancer. Methods This randomized controlled phase III study was conducted at the Clinical Oncology Department, Suez Canal University Hospital. Eligible participants were de-novo or metachronous metastatic prostate cancer patients with Eastern Cooperative Oncology Group performance status of 0–2. Participants were randomized to receive either cytoreductive prostate-directed RT in addition to standard care or standard care alone. The conventional radiation schedule of 70 Gy/35 fractions or the hypofractionated schedule of 55 Gy/20 fractions were delivered. The primary endpoint was biochemical progression-free survival (BPFS), and secondary endpoints included clinical response, and overall survival (OS). Survival and post-hoc analyses were performed using Cox regression and the Kaplan-Meier method with the log-rank test. Results Between November 23, 2020, and November 21, 2022, 70 patients were enrolled in this study. Of them, 34 patients were assigned to the prostate radiotherapy group, and 29 patients were assigned to the control group. At a median follow-up of 12 months, the median BPFS has not been reached for the prostate radiotherapy group compared to 4.067 months for the control group (HR: 0.147, p < 0.001). Subgroup analysis showed that the median BPFS was statistically significantly correlated with low-volume (95% CI, 0.004 to 0.262, p = 0·001) and hormonal-sensitive metastatic disease (95% CI, 0.010 to 0.192, p < 0·001). The median OS was 16.33 months for the prostate-radiotherapy group compared to 11.33 months for the control group (HR: 0.313, p = 0.003). Conclusion Prostate-directed RT improved BPFS and OS in metastatic prostate cancer patients, particularly in those with low volume and hormonal-sensitive disease. Trial Registration: This trial is registered on (27/4/2023) with pactr.samrc.ac.za, PACTR202305854600529, URL: https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=25510" @default.
- W4385469215 created "2023-08-02" @default.
- W4385469215 creator A5046749687 @default.
- W4385469215 creator A5054310693 @default.
- W4385469215 creator A5056380723 @default.
- W4385469215 creator A5083101435 @default.
- W4385469215 creator A5092578786 @default.
- W4385469215 date "2023-08-02" @default.
- W4385469215 modified "2023-09-25" @default.
- W4385469215 title "Biochemical Outcome in Metastatic Prostate Cancer Patients Following Prostate-Directed Radiotherapy" @default.
- W4385469215 cites W2050146329 @default.
- W4385469215 cites W2053981335 @default.
- W4385469215 cites W2105647806 @default.
- W4385469215 cites W2147509995 @default.
- W4385469215 cites W2347114208 @default.
- W4385469215 cites W2463183688 @default.
- W4385469215 cites W2577594437 @default.
- W4385469215 cites W2604203648 @default.
- W4385469215 cites W2752846017 @default.
- W4385469215 cites W2768573365 @default.
- W4385469215 cites W2795391818 @default.
- W4385469215 cites W2894350218 @default.
- W4385469215 cites W2897236707 @default.
- W4385469215 cites W2903726898 @default.
- W4385469215 cites W2914551740 @default.
- W4385469215 cites W2919810454 @default.
- W4385469215 cites W2937483840 @default.
- W4385469215 cites W2983850189 @default.
- W4385469215 cites W3090477216 @default.
- W4385469215 cites W3092344805 @default.
- W4385469215 cites W3128646645 @default.
- W4385469215 cites W3151408999 @default.
- W4385469215 cites W4281639779 @default.
- W4385469215 cites W4282942481 @default.
- W4385469215 cites W4283822941 @default.
- W4385469215 cites W4315754639 @default.
- W4385469215 doi "https://doi.org/10.21203/rs.3.rs-3128118/v1" @default.
- W4385469215 hasPublicationYear "2023" @default.
- W4385469215 type Work @default.
- W4385469215 citedByCount "0" @default.
- W4385469215 crossrefType "posted-content" @default.
- W4385469215 hasAuthorship W4385469215A5046749687 @default.
- W4385469215 hasAuthorship W4385469215A5054310693 @default.
- W4385469215 hasAuthorship W4385469215A5056380723 @default.
- W4385469215 hasAuthorship W4385469215A5083101435 @default.
- W4385469215 hasAuthorship W4385469215A5092578786 @default.
- W4385469215 hasBestOaLocation W43854692151 @default.
- W4385469215 hasConcept C121608353 @default.
- W4385469215 hasConcept C126322002 @default.
- W4385469215 hasConcept C126894567 @default.
- W4385469215 hasConcept C143998085 @default.
- W4385469215 hasConcept C168563851 @default.
- W4385469215 hasConcept C203092338 @default.
- W4385469215 hasConcept C2776235491 @default.
- W4385469215 hasConcept C2778311097 @default.
- W4385469215 hasConcept C2780192828 @default.
- W4385469215 hasConcept C509974204 @default.
- W4385469215 hasConcept C71924100 @default.
- W4385469215 hasConceptScore W4385469215C121608353 @default.
- W4385469215 hasConceptScore W4385469215C126322002 @default.
- W4385469215 hasConceptScore W4385469215C126894567 @default.
- W4385469215 hasConceptScore W4385469215C143998085 @default.
- W4385469215 hasConceptScore W4385469215C168563851 @default.
- W4385469215 hasConceptScore W4385469215C203092338 @default.
- W4385469215 hasConceptScore W4385469215C2776235491 @default.
- W4385469215 hasConceptScore W4385469215C2778311097 @default.
- W4385469215 hasConceptScore W4385469215C2780192828 @default.
- W4385469215 hasConceptScore W4385469215C509974204 @default.
- W4385469215 hasConceptScore W4385469215C71924100 @default.
- W4385469215 hasLocation W43854692151 @default.
- W4385469215 hasOpenAccess W4385469215 @default.
- W4385469215 hasPrimaryLocation W43854692151 @default.
- W4385469215 hasRelatedWork W1980245127 @default.
- W4385469215 hasRelatedWork W2034738338 @default.
- W4385469215 hasRelatedWork W2038565121 @default.
- W4385469215 hasRelatedWork W2127440557 @default.
- W4385469215 hasRelatedWork W2371104354 @default.
- W4385469215 hasRelatedWork W2372081072 @default.
- W4385469215 hasRelatedWork W2590008096 @default.
- W4385469215 hasRelatedWork W2897445903 @default.
- W4385469215 hasRelatedWork W3082324229 @default.
- W4385469215 hasRelatedWork W3129209394 @default.
- W4385469215 isParatext "false" @default.
- W4385469215 isRetracted "false" @default.
- W4385469215 workType "article" @default.