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• W4385476828 abstract "Heart transplantation for patients with end-stage heart failure refractory to medical therapy has remained definitive treatment with significant advances in posttransplant care. Despite improvement in postoperative morbidity and mortality, acute cellular rejection (ACR) and antibody-mediated rejection (AMR) remain substantial challenges that can lead to allograft failure and patient mortality. Immunosuppressive agents have been the mainstay of both prevention and treatment for ACR and AMR; however, many challenges exist with traditional therapies. There are a multitude of molecular pathways involved in mediating the humoral and cellular response to rejection, offering various targets for treatment. This review summarizes therapies used in the management of ACR and AMR as extrapolated from use in induction therapy and treatment of other solid-organ transplant rejection. Future studies focused on cardiac transplant recipients are needed to expand therapeutic options." @default.
• W4385476828 created "2023-08-03" @default.
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• W4385476828 date "2023-08-02" @default.
• W4385476828 modified "2023-09-27" @default.
• W4385476828 title "Cardiac Allograft Rejection: Strategies for Success in the Face of Immune Challenges" @default.
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• W4385476828 doi "https://doi.org/10.1097/crd.0000000000000596" @default.
• W4385476828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37530529" @default.
• W4385476828 hasPublicationYear "2023" @default.
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