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- W4385481509 abstract "Blinding of Participants to Treatment and Implications for Assessments of Efficacy in Attention-Deficit/Hyperactivity Disorder Micronutrient StudyJournal of the American Academy of Child & Adolescent PsychiatryPreviewI read with interest the article “Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial” by Johnstone et al.,1 and have questions regarding the adequacy of the blinding, especially regarding the clinician raters. The authors state, “Correct guesses about treatment assignment were not significantly different from chance: children guessed correctly 51% of the time, parents 63%, and research assistants 67%.” (The description “research assistants” [RAs] is the group that administered the Clinical Global Impression [CGI] scale as 1 of 2 primary outcome variables.) The authors offer no statistical analysis to support their conclusion of “not significantly different from chance.” Yet the time and expense of taking 9 daily tablets of the Hardy Nutritionals formulation in an ongoing way are not insignificant, justifying a rigorous approach in evaluating efficacy. Full-Text PDF" @default.
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- W4385481509 date "2023-08-01" @default.
- W4385481509 modified "2023-09-25" @default.
- W4385481509 title "Dr. Johnstone et al. Reply to Dr. Hamilton" @default.
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- W4385481509 doi "https://doi.org/10.1016/j.jaac.2023.07.992" @default.
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