Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385482852> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4385482852 abstract "Abstract Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by immune disorders contributing to its pathogenesis. This study aimed to identify key biomarkers and immune-related pathways implicated in the progression of RA, as well as investigate the relationship between these biomarkers and immune cell infiltration in RA. Methods: Gene microarray data from the GEO database were utilized. Key differentially expressed genes (DEGs) associated with RA were identified through differential expression analysis and weighted gene co-expression network analysis (WGCNA). Functional enrichment analyses, including GO, KEGG, and GSEA, were performed on the key DEGs. Hub gene markers were determined using LASSO regression of the key DEGs. Single-sample GSEA (ssGSEA) was employed to analyze the infiltration levels of 28 types of immune cells in the expression profile and their relationship with hub gene markers. Additionally, the diagnostic accuracy of the hub markers for RA was evaluated using receiver operating characteristic curve (ROC) analysis. Results: A total of 2596 differential genes were identified, and 28 co-expression modules were obtained through WGCNA, with the green module showing the highest correlation with RA. By combining the differential genes, 496 intersecting genes were obtained. LASSO analysis yielded six hub genes (AIM2, ANKRD12, CXCL10, NCOA6, PPP3CA, and SRPR) as potential biomarkers for RA. The analysis of immune infiltration revealed significant relationships among activated B cells, activated CD4 + T cells, activated CD8 + T cells, and effector memory CD4 + T cells. ROC curve analysis demonstrated the excellent diagnostic value of the six hub genes. Functional enrichment analysis of the differential genes revealed their predominant enrichment in immune- and inflammation-related pathways. Conclusion: The findings suggest that the six hub genes (AIM2, ANKRD12, CXCL10, NCOA6, PPP3CA, and SRPR) may play a role in the progression of RA through immune-related signal pathways. B cells, CD4 + T cells, CD8 + T cells, monocytes, and dendritic cells appear to be closely associated with the pathogenesis of RA." @default.
- W4385482852 created "2023-08-03" @default.
- W4385482852 creator A5031074362 @default.
- W4385482852 creator A5037064390 @default.
- W4385482852 creator A5077357809 @default.
- W4385482852 date "2023-08-02" @default.
- W4385482852 modified "2023-09-27" @default.
- W4385482852 title "Identification of key genes and immune profile in rheumatoid arthritis by bioinformatics analysis" @default.
- W4385482852 cites W1966107523 @default.
- W4385482852 cites W1966327575 @default.
- W4385482852 cites W1978567076 @default.
- W4385482852 cites W1986086086 @default.
- W4385482852 cites W2013375004 @default.
- W4385482852 cites W2046412495 @default.
- W4385482852 cites W2074154498 @default.
- W4385482852 cites W2090489482 @default.
- W4385482852 cites W2114678151 @default.
- W4385482852 cites W2136967594 @default.
- W4385482852 cites W2149199519 @default.
- W4385482852 cites W2211397752 @default.
- W4385482852 cites W2301896663 @default.
- W4385482852 cites W2589710212 @default.
- W4385482852 cites W2594075087 @default.
- W4385482852 cites W2610107585 @default.
- W4385482852 cites W3002498794 @default.
- W4385482852 cites W3022414345 @default.
- W4385482852 cites W3041861217 @default.
- W4385482852 cites W3111539722 @default.
- W4385482852 cites W3175752499 @default.
- W4385482852 cites W4211111012 @default.
- W4385482852 cites W4220943748 @default.
- W4385482852 cites W4239943677 @default.
- W4385482852 cites W4310809201 @default.
- W4385482852 doi "https://doi.org/10.21203/rs.3.rs-3193853/v1" @default.
- W4385482852 hasPublicationYear "2023" @default.
- W4385482852 type Work @default.
- W4385482852 citedByCount "0" @default.
- W4385482852 crossrefType "posted-content" @default.
- W4385482852 hasAuthorship W4385482852A5031074362 @default.
- W4385482852 hasAuthorship W4385482852A5037064390 @default.
- W4385482852 hasAuthorship W4385482852A5077357809 @default.
- W4385482852 hasBestOaLocation W43854828521 @default.
- W4385482852 hasConcept C104317684 @default.
- W4385482852 hasConcept C126322002 @default.
- W4385482852 hasConcept C150194340 @default.
- W4385482852 hasConcept C152724338 @default.
- W4385482852 hasConcept C162317418 @default.
- W4385482852 hasConcept C18431079 @default.
- W4385482852 hasConcept C186836561 @default.
- W4385482852 hasConcept C203014093 @default.
- W4385482852 hasConcept C2777575956 @default.
- W4385482852 hasConcept C54355233 @default.
- W4385482852 hasConcept C58471807 @default.
- W4385482852 hasConcept C70721500 @default.
- W4385482852 hasConcept C71924100 @default.
- W4385482852 hasConcept C8415881 @default.
- W4385482852 hasConcept C86803240 @default.
- W4385482852 hasConcept C8891405 @default.
- W4385482852 hasConceptScore W4385482852C104317684 @default.
- W4385482852 hasConceptScore W4385482852C126322002 @default.
- W4385482852 hasConceptScore W4385482852C150194340 @default.
- W4385482852 hasConceptScore W4385482852C152724338 @default.
- W4385482852 hasConceptScore W4385482852C162317418 @default.
- W4385482852 hasConceptScore W4385482852C18431079 @default.
- W4385482852 hasConceptScore W4385482852C186836561 @default.
- W4385482852 hasConceptScore W4385482852C203014093 @default.
- W4385482852 hasConceptScore W4385482852C2777575956 @default.
- W4385482852 hasConceptScore W4385482852C54355233 @default.
- W4385482852 hasConceptScore W4385482852C58471807 @default.
- W4385482852 hasConceptScore W4385482852C70721500 @default.
- W4385482852 hasConceptScore W4385482852C71924100 @default.
- W4385482852 hasConceptScore W4385482852C8415881 @default.
- W4385482852 hasConceptScore W4385482852C86803240 @default.
- W4385482852 hasConceptScore W4385482852C8891405 @default.
- W4385482852 hasLocation W43854828521 @default.
- W4385482852 hasOpenAccess W4385482852 @default.
- W4385482852 hasPrimaryLocation W43854828521 @default.
- W4385482852 hasRelatedWork W1531528770 @default.
- W4385482852 hasRelatedWork W2001670874 @default.
- W4385482852 hasRelatedWork W2053053668 @default.
- W4385482852 hasRelatedWork W2112336316 @default.
- W4385482852 hasRelatedWork W2358933573 @default.
- W4385482852 hasRelatedWork W2386890770 @default.
- W4385482852 hasRelatedWork W262379139 @default.
- W4385482852 hasRelatedWork W2796636403 @default.
- W4385482852 hasRelatedWork W2978178681 @default.
- W4385482852 hasRelatedWork W3032874291 @default.
- W4385482852 isParatext "false" @default.
- W4385482852 isRetracted "false" @default.
- W4385482852 workType "article" @default.