FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385483863> ?p ?o ?g. }

• W4385483863 abstract "Abstract Early in life, behavioural and cognitive traits associated with risk for developing a psychiatric condition are broad and undifferentiated. As children develop, these traits differentiate into characteristic clusters of symptoms and behaviours that ultimately form the basis of diagnostic categories. Understanding this differentiation process - in the context of genetic risk for psychiatric conditions, which is highly generalised - can improve early detection and treatment. We modelled the differentiation of behavioural and emotional problems from age 1.5-5 years (behavioural problems – emotional problems = differentiation score) in a pre-registered study of ~79 000 children from the population-based Norwegian Mother, Father, and Child Cohort Study. We used genomic structural equation modelling to identify genetic signal in differentiation and the total level of behavioural and emotional problems, investigating their links with 11 psychiatric and neurodevelopmental conditions. We examined associations of polygenic scores (PGS) with differentiation and total problems and assessed the relative contributions of direct and indirect genetic effects in over 33 000 family trios. Differentiation exhibited detectable common variant heritability ( h 2 SNP = 0.023 [0.017, 0.029]), and was primarily genetically correlated with psychiatric conditions via a “neurodevelopmental” factor. PGS analyses revealed a substantial association between polygenic liability to ADHD and differentiation (β = 0.09 [0.08, 0.11]), and a weaker association with total problems (β = 0.05 [0.04, 0.06]). Trio-PGS analyses indicated predominantly direct genetic effects on both outcomes. We uncovered systematic genomic signal in the differentiation process, mostly related to common variants associated with neurodevelopmental conditions. Investigating the co-occurrence and differentiation of behavioural and emotional problems may enhance our ability to detect and eventually prevent the emergence of psychiatric conditions." @default.
• W4385483863 created "2023-08-03" @default.
• W4385483863 creator A5002328249 @default.
• W4385483863 creator A5024292831 @default.
• W4385483863 creator A5026784962 @default.
• W4385483863 creator A5027969287 @default.
• W4385483863 creator A5048398431 @default.
• W4385483863 creator A5055456170 @default.
• W4385483863 creator A5064324947 @default.
• W4385483863 creator A5064842675 @default.
• W4385483863 creator A5088553499 @default.
• W4385483863 date "2023-08-02" @default.
• W4385483863 modified "2023-09-27" @default.
• W4385483863 title "The genetic architecture of differentiating behavioural and emotional problems in early life" @default.
• W4385483863 cites W1906492347 @default.
• W4385483863 cites W1991838756 @default.
• W4385483863 cites W1996299724 @default.
• W4385483863 cites W2045227722 @default.
• W4385483863 cites W2080125855 @default.
• W4385483863 cites W2097074714 @default.
• W4385483863 cites W2099580882 @default.
• W4385483863 cites W2106036991 @default.
• W4385483863 cites W2110048796 @default.
• W4385483863 cites W2112878386 @default.
• W4385483863 cites W2120654343 @default.
• W4385483863 cites W2135556705 @default.
• W4385483863 cites W2142500707 @default.
• W4385483863 cites W2159194460 @default.
• W4385483863 cites W2163233985 @default.
• W4385483863 cites W2170684975 @default.
• W4385483863 cites W2171022790 @default.
• W4385483863 cites W2195783463 @default.
• W4385483863 cites W2297605059 @default.
• W4385483863 cites W2319889034 @default.
• W4385483863 cites W2329215203 @default.
• W4385483863 cites W2402373502 @default.
• W4385483863 cites W2610359325 @default.
• W4385483863 cites W2626606138 @default.
• W4385483863 cites W2739834351 @default.
• W4385483863 cites W2770085798 @default.
• W4385483863 cites W2770092353 @default.
• W4385483863 cites W2788930055 @default.
• W4385483863 cites W2791854743 @default.
• W4385483863 cites W2793036539 @default.
• W4385483863 cites W2801776818 @default.
• W4385483863 cites W2802815532 @default.
• W4385483863 cites W2891530254 @default.
• W4385483863 cites W2908945164 @default.
• W4385483863 cites W2911487850 @default.
• W4385483863 cites W2912304870 @default.
• W4385483863 cites W2914482125 @default.
• W4385483863 cites W2914834617 @default.
• W4385483863 cites W2917071648 @default.
• W4385483863 cites W2937611850 @default.
• W4385483863 cites W2949479576 @default.
• W4385483863 cites W2952374428 @default.
• W4385483863 cites W2960372990 @default.
• W4385483863 cites W2973656706 @default.
• W4385483863 cites W2995171440 @default.
• W4385483863 cites W3004083863 @default.
• W4385483863 cites W3016957018 @default.
• W4385483863 cites W3044605697 @default.
• W4385483863 cites W3093753350 @default.
• W4385483863 cites W3126847862 @default.
• W4385483863 cites W3141663364 @default.
• W4385483863 cites W3162259891 @default.
• W4385483863 cites W3162800482 @default.
• W4385483863 cites W3187785477 @default.
• W4385483863 cites W4206175800 @default.
• W4385483863 cites W4223520055 @default.
• W4385483863 cites W4229455035 @default.
• W4385483863 cites W4281787855 @default.
• W4385483863 cites W4283770842 @default.
• W4385483863 cites W4316143243 @default.
• W4385483863 cites W4382862602 @default.
• W4385483863 doi "https://doi.org/10.21203/rs.3.rs-3223835/v1" @default.
• W4385483863 hasPublicationYear "2023" @default.
• W4385483863 type Work @default.
• W4385483863 citedByCount "0" @default.
• W4385483863 crossrefType "posted-content" @default.
• W4385483863 hasAuthorship W4385483863A5002328249 @default.
• W4385483863 hasAuthorship W4385483863A5024292831 @default.
• W4385483863 hasAuthorship W4385483863A5026784962 @default.
• W4385483863 hasAuthorship W4385483863A5027969287 @default.
• W4385483863 hasAuthorship W4385483863A5048398431 @default.
• W4385483863 hasAuthorship W4385483863A5055456170 @default.
• W4385483863 hasAuthorship W4385483863A5064324947 @default.
• W4385483863 hasAuthorship W4385483863A5064842675 @default.
• W4385483863 hasAuthorship W4385483863A5088553499 @default.
• W4385483863 hasBestOaLocation W43854838631 @default.
• W4385483863 hasConcept C126322002 @default.
• W4385483863 hasConcept C138885662 @default.
• W4385483863 hasConcept C142853389 @default.
• W4385483863 hasConcept C151730666 @default.
• W4385483863 hasConcept C15744967 @default.
• W4385483863 hasConcept C161890455 @default.
• W4385483863 hasConcept C2779343474 @default.
• W4385483863 hasConcept C2908647359 @default.
• W4385483863 hasConcept C41895202 @default.
• W4385483863 hasConcept C542102704 @default.

• next