FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385484018> ?p ?o ?g. }

• W4385484018 endingPage "762" @default.
• W4385484018 startingPage "762" @default.
• W4385484018 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> The natural day-night cycle synchronizes our circadian rhythms, but modern work practices like night shifts disrupt this pattern, leading to increased exposure to nighttime light. This exposure is linked to various health issues. While some studies have explored the effects of night shifts on human circadian rhythms, there is limited research on the consequences of long-term exposure to shift-work light conditions. Rodents can provide valuable insights into these effects. This study aimed to examine how short- or long-term exposure to rotating shifts and chronic jetlag affects the core circadian oscillators in the liver and skin of mammals.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold><ns4:bold> </ns4:bold>C57BL/6J male mice were subjected to simulated shift-work light conditions, including short-term or long-term rotating shifts and chronic jet-lag conditions. Liver and skin samples were collected every four hours over a 24-hour period on the second day of constant darkness. RNA was extracted and qRT-PCR analysis was conducted to measure the circadian gene expression in liver and skin tissues. Circadian rhythm analysis using CircaCompare compared the control group to mice exposed to shift-work light conditions.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Results: </ns4:bold>The liver's circadian clock is significantly altered in mice under long-term rotating shift conditions, with a lesser but still noticeable impact in mice experiencing chronic jetlag. However, short-term rotating shift conditions do not significantly affect the liver's circadian clock. Conversely, all three simulated shift conditions affect the skin's circadian clock, indicating that the skin clock is more sensitive to shift-work light conditions than the liver clock. Compared to the liver, the skin's circadian clock is greatly affected by long-term rotating shift conditions.</ns4:p><ns4:p> </ns4:p><ns4:p> <ns4:bold>Conclusions: </ns4:bold>The study findings indicate more pronounced disturbances in the canonical clock genes of the skin compared to the liver under simulated shift-work light conditions. These results suggest that the skin clock is more vulnerable to the effects of shift-work.</ns4:p>" @default.
• W4385484018 created "2023-08-03" @default.
• W4385484018 creator A5046635310 @default.
• W4385484018 creator A5050158902 @default.
• W4385484018 creator A5057745514 @default.
• W4385484018 creator A5068878039 @default.
• W4385484018 date "2023-08-02" @default.
• W4385484018 modified "2023-10-14" @default.
• W4385484018 title "The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study" @default.
• W4385484018 cites W1577577364 @default.
• W4385484018 cites W1607785571 @default.
• W4385484018 cites W1966450619 @default.
• W4385484018 cites W1974696079 @default.
• W4385484018 cites W2000520092 @default.
• W4385484018 cites W2005239576 @default.
• W4385484018 cites W2017891854 @default.
• W4385484018 cites W2031750133 @default.
• W4385484018 cites W2061769555 @default.
• W4385484018 cites W2065793289 @default.
• W4385484018 cites W2077038726 @default.
• W4385484018 cites W2082673643 @default.
• W4385484018 cites W2090816060 @default.
• W4385484018 cites W2091531174 @default.
• W4385484018 cites W2101173582 @default.
• W4385484018 cites W2107083462 @default.
• W4385484018 cites W2134377844 @default.
• W4385484018 cites W2140233939 @default.
• W4385484018 cites W2140693749 @default.
• W4385484018 cites W2149903385 @default.
• W4385484018 cites W2150076905 @default.
• W4385484018 cites W2155667080 @default.
• W4385484018 cites W2161934862 @default.
• W4385484018 cites W2162008969 @default.
• W4385484018 cites W2164628441 @default.
• W4385484018 cites W2343522818 @default.
• W4385484018 cites W2406604088 @default.
• W4385484018 cites W2505703250 @default.
• W4385484018 cites W2556811098 @default.
• W4385484018 cites W2571830130 @default.
• W4385484018 cites W2607662745 @default.
• W4385484018 cites W2739538381 @default.
• W4385484018 cites W2740621908 @default.
• W4385484018 cites W2765681392 @default.
• W4385484018 cites W2802571577 @default.
• W4385484018 cites W2814914586 @default.
• W4385484018 cites W2890531599 @default.
• W4385484018 cites W2900770953 @default.
• W4385484018 cites W2910084517 @default.
• W4385484018 cites W2943470918 @default.
• W4385484018 cites W2947105529 @default.
• W4385484018 cites W2949422953 @default.
• W4385484018 cites W2953383732 @default.
• W4385484018 cites W2979521371 @default.
• W4385484018 cites W2979681334 @default.
• W4385484018 cites W2999623586 @default.
• W4385484018 cites W3025003034 @default.
• W4385484018 cites W3026983523 @default.
• W4385484018 cites W3092998467 @default.
• W4385484018 cites W3120868419 @default.
• W4385484018 cites W3132046378 @default.
• W4385484018 cites W3175088394 @default.
• W4385484018 doi "https://doi.org/10.12688/f1000research.136998.2" @default.
• W4385484018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37576540" @default.
• W4385484018 hasPublicationYear "2023" @default.
• W4385484018 type Work @default.
• W4385484018 citedByCount "0" @default.
• W4385484018 crossrefType "journal-article" @default.
• W4385484018 hasAuthorship W4385484018A5046635310 @default.
• W4385484018 hasAuthorship W4385484018A5050158902 @default.
• W4385484018 hasAuthorship W4385484018A5057745514 @default.
• W4385484018 hasAuthorship W4385484018A5068878039 @default.
• W4385484018 hasBestOaLocation W43854840181 @default.
• W4385484018 hasConcept C121446783 @default.
• W4385484018 hasConcept C126322002 @default.
• W4385484018 hasConcept C134018914 @default.
• W4385484018 hasConcept C169760540 @default.
• W4385484018 hasConcept C2776176791 @default.
• W4385484018 hasConcept C38606739 @default.
• W4385484018 hasConcept C42407357 @default.
• W4385484018 hasConcept C71924100 @default.
• W4385484018 hasConcept C86803240 @default.
• W4385484018 hasConceptScore W4385484018C121446783 @default.
• W4385484018 hasConceptScore W4385484018C126322002 @default.
• W4385484018 hasConceptScore W4385484018C134018914 @default.
• W4385484018 hasConceptScore W4385484018C169760540 @default.
• W4385484018 hasConceptScore W4385484018C2776176791 @default.
• W4385484018 hasConceptScore W4385484018C38606739 @default.
• W4385484018 hasConceptScore W4385484018C42407357 @default.
• W4385484018 hasConceptScore W4385484018C71924100 @default.
• W4385484018 hasConceptScore W4385484018C86803240 @default.
• W4385484018 hasFunder F4320332161 @default.
• W4385484018 hasLocation W43854840181 @default.
• W4385484018 hasLocation W43854840182 @default.
• W4385484018 hasOpenAccess W4385484018 @default.
• W4385484018 hasPrimaryLocation W43854840181 @default.
• W4385484018 hasRelatedWork W1511740843 @default.
• W4385484018 hasRelatedWork W2029004540 @default.
• W4385484018 hasRelatedWork W2051408988 @default.

• next