Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385491067> ?p ?o ?g. }
- W4385491067 endingPage "120762" @default.
- W4385491067 startingPage "120762" @default.
- W4385491067 abstract "Diffuse gliomas are tumors that arise from glial or glial progenitor cells. They are currently classified as astrocytoma isocitrate dehydrogenase (IDH)-mutant or oligodendroglioma IDH-mutant, and 1p/19q-codeleted, both slower-growing tumors, or glioblastoma (GBM), a more aggressive tumor. Despite advances in the diagnosis and treatment of gliomas, the median survival time after diagnosis of GBM remains low, approximately 15 months, with a 5-year overall survival rate of only 6.8%. Therefore, new biomarkers that could support the earlier diagnosis and prognosis of these tumors would be of great value. MUC17, a membrane-bound mucin, has been identified as a potential biomarker for several tumors. However, the role of this mucin in adult gliomas has not yet been explored. Here, we show for the first time, in a retrospective study and by in silico analysis that MUC17 is one of the relevant mutant genes in adult gliomas. Moreover, that an increase in MUC17 methylation correlates with an increase in glioma malignancy grade. Patients with MUC17 mutations had a poorer prognosis than their wild-type counterparts in both GBM and non-GBM glioma cohorts. We also analyzed mutational profiles that correlated strongly with poor survival. Therefore, in this study, we present a new potential biomarker for further investigation, especially for the prognosis of adult diffuse gliomas." @default.
- W4385491067 created "2023-08-03" @default.
- W4385491067 creator A5034664424 @default.
- W4385491067 creator A5046589382 @default.
- W4385491067 date "2023-09-01" @default.
- W4385491067 modified "2023-10-02" @default.
- W4385491067 title "MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients" @default.
- W4385491067 cites W1972163114 @default.
- W4385491067 cites W2009720434 @default.
- W4385491067 cites W2016661249 @default.
- W4385491067 cites W2025183726 @default.
- W4385491067 cites W2034253664 @default.
- W4385491067 cites W2047710431 @default.
- W4385491067 cites W2073426323 @default.
- W4385491067 cites W2078672365 @default.
- W4385491067 cites W2096287682 @default.
- W4385491067 cites W2105100844 @default.
- W4385491067 cites W2109816625 @default.
- W4385491067 cites W2114843025 @default.
- W4385491067 cites W2138336030 @default.
- W4385491067 cites W2143078369 @default.
- W4385491067 cites W2149441684 @default.
- W4385491067 cites W2152715949 @default.
- W4385491067 cites W2160776641 @default.
- W4385491067 cites W2263206910 @default.
- W4385491067 cites W2366536035 @default.
- W4385491067 cites W2524702547 @default.
- W4385491067 cites W2568859793 @default.
- W4385491067 cites W2570830222 @default.
- W4385491067 cites W2785548318 @default.
- W4385491067 cites W2786714651 @default.
- W4385491067 cites W2791488537 @default.
- W4385491067 cites W2794804602 @default.
- W4385491067 cites W2795441313 @default.
- W4385491067 cites W2795941120 @default.
- W4385491067 cites W2795989238 @default.
- W4385491067 cites W2796153225 @default.
- W4385491067 cites W2796153844 @default.
- W4385491067 cites W2796292093 @default.
- W4385491067 cites W2796572741 @default.
- W4385491067 cites W2894102714 @default.
- W4385491067 cites W2908755714 @default.
- W4385491067 cites W2911871569 @default.
- W4385491067 cites W2914071842 @default.
- W4385491067 cites W2914942635 @default.
- W4385491067 cites W2953298857 @default.
- W4385491067 cites W2954309731 @default.
- W4385491067 cites W2955311308 @default.
- W4385491067 cites W2967940492 @default.
- W4385491067 cites W2980663762 @default.
- W4385491067 cites W2997488443 @default.
- W4385491067 cites W3010810358 @default.
- W4385491067 cites W3011320584 @default.
- W4385491067 cites W3020099303 @default.
- W4385491067 cites W3038964327 @default.
- W4385491067 cites W3045546645 @default.
- W4385491067 cites W3098926804 @default.
- W4385491067 cites W3126000514 @default.
- W4385491067 cites W3126609356 @default.
- W4385491067 cites W3127739024 @default.
- W4385491067 cites W3134652210 @default.
- W4385491067 cites W3135035839 @default.
- W4385491067 cites W3154148205 @default.
- W4385491067 cites W3174246647 @default.
- W4385491067 cites W3203918618 @default.
- W4385491067 cites W3209578806 @default.
- W4385491067 cites W4200327950 @default.
- W4385491067 cites W4220699321 @default.
- W4385491067 cites W4225271949 @default.
- W4385491067 cites W4283691907 @default.
- W4385491067 cites W4292092775 @default.
- W4385491067 cites W4313897800 @default.
- W4385491067 cites W571060166 @default.
- W4385491067 doi "https://doi.org/10.1016/j.jns.2023.120762" @default.
- W4385491067 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37562166" @default.
- W4385491067 hasPublicationYear "2023" @default.
- W4385491067 type Work @default.
- W4385491067 citedByCount "1" @default.
- W4385491067 countsByYear W43854910672023 @default.
- W4385491067 crossrefType "journal-article" @default.
- W4385491067 hasAuthorship W4385491067A5034664424 @default.
- W4385491067 hasAuthorship W4385491067A5046589382 @default.
- W4385491067 hasConcept C104317684 @default.
- W4385491067 hasConcept C126322002 @default.
- W4385491067 hasConcept C127848430 @default.
- W4385491067 hasConcept C142724271 @default.
- W4385491067 hasConcept C143065580 @default.
- W4385491067 hasConcept C143998085 @default.
- W4385491067 hasConcept C181199279 @default.
- W4385491067 hasConcept C2777150147 @default.
- W4385491067 hasConcept C2777931997 @default.
- W4385491067 hasConcept C2778227246 @default.
- W4385491067 hasConcept C2778880634 @default.
- W4385491067 hasConcept C2779399171 @default.
- W4385491067 hasConcept C2781197716 @default.
- W4385491067 hasConcept C2910969760 @default.
- W4385491067 hasConcept C502942594 @default.
- W4385491067 hasConcept C54355233 @default.