Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385492061> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4385492061 abstract "The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in Caenorhabditis elegans. These transcription factors coordinate nutrient sensing with carbohydrate and lipid metabolism across the evolutionary spectrum. While most studies have focused on the downstream outputs, little is known about the upstream inputs that regulate these transcription factors in a live organism. Here, we found that knockdown of various glucose metabolic enzymes decreases MML-1 localization in the nucleus and identified two hexokinase isozymes, hxk-1 and hxk-2, as the most vigorous regulators of MML-1 function. Upon hexokinase knockdown, MML-1 redistributes to mitochondria and lipid droplets (LD) and concomitantly, transcriptional targets are downregulated and germline longevity is abolished. Further, we found that hxk-1 regulates MML-1 through mitochondrial β-oxidation, while hxk-2 regulates MML-1 through modulating the pentose phosphate pathway (PPP) and its coordinated association with lipid droplets. Similarly, inhibition of the PPP rescues mammalian MondoA nuclear translocation and transcriptional function upon starvation. These studies reveal how metabolic signals and organellar communication regulate a key convergent metabolic transcription factor to promote longevity." @default.
- W4385492061 created "2023-08-03" @default.
- W4385492061 creator A5016637247 @default.
- W4385492061 creator A5028016524 @default.
- W4385492061 creator A5064449778 @default.
- W4385492061 creator A5092162563 @default.
- W4385492061 creator A5092162564 @default.
- W4385492061 date "2023-08-02" @default.
- W4385492061 modified "2023-10-11" @default.
- W4385492061 title "Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics" @default.
- W4385492061 doi "https://doi.org/10.7554/elife.89225" @default.
- W4385492061 hasPublicationYear "2023" @default.
- W4385492061 type Work @default.
- W4385492061 citedByCount "0" @default.
- W4385492061 crossrefType "posted-content" @default.
- W4385492061 hasAuthorship W4385492061A5016637247 @default.
- W4385492061 hasAuthorship W4385492061A5028016524 @default.
- W4385492061 hasAuthorship W4385492061A5064449778 @default.
- W4385492061 hasAuthorship W4385492061A5092162563 @default.
- W4385492061 hasAuthorship W4385492061A5092162564 @default.
- W4385492061 hasBestOaLocation W43854920611 @default.
- W4385492061 hasConcept C104317684 @default.
- W4385492061 hasConcept C138885662 @default.
- W4385492061 hasConcept C173396325 @default.
- W4385492061 hasConcept C179926584 @default.
- W4385492061 hasConcept C20251656 @default.
- W4385492061 hasConcept C27153228 @default.
- W4385492061 hasConcept C2776759703 @default.
- W4385492061 hasConcept C2778944004 @default.
- W4385492061 hasConcept C2779826832 @default.
- W4385492061 hasConcept C41895202 @default.
- W4385492061 hasConcept C54355233 @default.
- W4385492061 hasConcept C55493867 @default.
- W4385492061 hasConcept C62231903 @default.
- W4385492061 hasConcept C86339819 @default.
- W4385492061 hasConcept C86803240 @default.
- W4385492061 hasConcept C95444343 @default.
- W4385492061 hasConceptScore W4385492061C104317684 @default.
- W4385492061 hasConceptScore W4385492061C138885662 @default.
- W4385492061 hasConceptScore W4385492061C173396325 @default.
- W4385492061 hasConceptScore W4385492061C179926584 @default.
- W4385492061 hasConceptScore W4385492061C20251656 @default.
- W4385492061 hasConceptScore W4385492061C27153228 @default.
- W4385492061 hasConceptScore W4385492061C2776759703 @default.
- W4385492061 hasConceptScore W4385492061C2778944004 @default.
- W4385492061 hasConceptScore W4385492061C2779826832 @default.
- W4385492061 hasConceptScore W4385492061C41895202 @default.
- W4385492061 hasConceptScore W4385492061C54355233 @default.
- W4385492061 hasConceptScore W4385492061C55493867 @default.
- W4385492061 hasConceptScore W4385492061C62231903 @default.
- W4385492061 hasConceptScore W4385492061C86339819 @default.
- W4385492061 hasConceptScore W4385492061C86803240 @default.
- W4385492061 hasConceptScore W4385492061C95444343 @default.
- W4385492061 hasLocation W43854920611 @default.
- W4385492061 hasLocation W43854920612 @default.
- W4385492061 hasOpenAccess W4385492061 @default.
- W4385492061 hasPrimaryLocation W43854920611 @default.
- W4385492061 hasRelatedWork W1969762238 @default.
- W4385492061 hasRelatedWork W2018050005 @default.
- W4385492061 hasRelatedWork W2059066801 @default.
- W4385492061 hasRelatedWork W2105070187 @default.
- W4385492061 hasRelatedWork W2516413931 @default.
- W4385492061 hasRelatedWork W3045989176 @default.
- W4385492061 hasRelatedWork W3134672425 @default.
- W4385492061 hasRelatedWork W3175391862 @default.
- W4385492061 hasRelatedWork W4282828730 @default.
- W4385492061 hasRelatedWork W4313385108 @default.
- W4385492061 isParatext "false" @default.
- W4385492061 isRetracted "false" @default.
- W4385492061 workType "article" @default.