Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385492096> ?p ?o ?g. }
- W4385492096 abstract "Warburg effect plays a crucial role in bladder cancer (Bca) development. However, the mechanism by which glycolysis is involved in Bca remains poorly understood. CircRNAs commonly play a regulatory role in tumor progression. Our study discovered and identified a novel circRNA, hsa_circ_0000235 (circ235), and investigated its role in the glycolytic process, which further results in the progression of Bca. We applied qRT-PCR to assess its clinicopathological relevance and evaluated its proliferation, migration, and glycolytic capacity. We investigated its mechanism using RNA immunoprecipitation, dual-luciferase reporters, and fluorescence in situ hybridization. The findings demonstrated that circ235 was dramatically increased in Bca tissues and was related to a worse prognosis. In vitro studies revealed that circ235 accelerated the rate of extracellular acidification and promoted glucose uptake and lactate manufacture in Bca cells. Additionally, it strengthened the proliferative and migratory capacities. Experiments on animals revealed that downregulating circ235 dramatically reduced carcinogenesis and tumor growth. Circ235 activates monocarboxylate transporter 4 (MCT4) by sponging miR-330-5p, which promotes glycolysis and tumor growth. In conclusion, these findings suggest that circ235 may be a viable molecular marker and therapeutic target for Bca." @default.
- W4385492096 created "2023-08-03" @default.
- W4385492096 creator A5008307109 @default.
- W4385492096 creator A5012072924 @default.
- W4385492096 creator A5033441324 @default.
- W4385492096 creator A5035822981 @default.
- W4385492096 creator A5039836111 @default.
- W4385492096 creator A5043031303 @default.
- W4385492096 creator A5075429312 @default.
- W4385492096 creator A5085095982 @default.
- W4385492096 creator A5091161457 @default.
- W4385492096 date "2023-08-02" @default.
- W4385492096 modified "2023-10-12" @default.
- W4385492096 title "Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p" @default.
- W4385492096 cites W1964897400 @default.
- W4385492096 cites W1981726010 @default.
- W4385492096 cites W2027786827 @default.
- W4385492096 cites W2035618305 @default.
- W4385492096 cites W2058835062 @default.
- W4385492096 cites W2064165694 @default.
- W4385492096 cites W2072451938 @default.
- W4385492096 cites W2117692326 @default.
- W4385492096 cites W2117977572 @default.
- W4385492096 cites W2124627517 @default.
- W4385492096 cites W2159793493 @default.
- W4385492096 cites W2161372685 @default.
- W4385492096 cites W2206843293 @default.
- W4385492096 cites W2210577735 @default.
- W4385492096 cites W2279077379 @default.
- W4385492096 cites W2291579888 @default.
- W4385492096 cites W2354444627 @default.
- W4385492096 cites W2519020116 @default.
- W4385492096 cites W2548324887 @default.
- W4385492096 cites W2557141539 @default.
- W4385492096 cites W2562182278 @default.
- W4385492096 cites W2571316371 @default.
- W4385492096 cites W2572160591 @default.
- W4385492096 cites W2593956604 @default.
- W4385492096 cites W2600581473 @default.
- W4385492096 cites W2601436215 @default.
- W4385492096 cites W2616072553 @default.
- W4385492096 cites W2744268790 @default.
- W4385492096 cites W2771637744 @default.
- W4385492096 cites W2804871461 @default.
- W4385492096 cites W2892613404 @default.
- W4385492096 cites W2910580002 @default.
- W4385492096 cites W2918298756 @default.
- W4385492096 cites W2936221437 @default.
- W4385492096 cites W2936931130 @default.
- W4385492096 cites W2945838677 @default.
- W4385492096 cites W2951498553 @default.
- W4385492096 cites W2972418453 @default.
- W4385492096 cites W2977508467 @default.
- W4385492096 cites W2980415036 @default.
- W4385492096 cites W2983004186 @default.
- W4385492096 cites W2985572656 @default.
- W4385492096 cites W2999853926 @default.
- W4385492096 cites W3013599325 @default.
- W4385492096 cites W3013656414 @default.
- W4385492096 cites W3023288864 @default.
- W4385492096 cites W3023397567 @default.
- W4385492096 cites W3023407845 @default.
- W4385492096 cites W3028304854 @default.
- W4385492096 cites W3029504802 @default.
- W4385492096 cites W3037567897 @default.
- W4385492096 cites W3080533150 @default.
- W4385492096 cites W3101709818 @default.
- W4385492096 cites W3111456402 @default.
- W4385492096 cites W3118249881 @default.
- W4385492096 cites W3123227540 @default.
- W4385492096 cites W3186648915 @default.
- W4385492096 cites W3215841463 @default.
- W4385492096 cites W4210744364 @default.
- W4385492096 cites W4226105885 @default.
- W4385492096 cites W4280518704 @default.
- W4385492096 cites W4280638470 @default.
- W4385492096 cites W4289522269 @default.
- W4385492096 cites W4294842401 @default.
- W4385492096 cites W4297348236 @default.
- W4385492096 cites W4298326312 @default.
- W4385492096 cites W4307003464 @default.
- W4385492096 cites W4323569363 @default.
- W4385492096 cites W4223455752 @default.
- W4385492096 doi "https://doi.org/10.1038/s41420-023-01582-z" @default.
- W4385492096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37532687" @default.
- W4385492096 hasPublicationYear "2023" @default.
- W4385492096 type Work @default.
- W4385492096 citedByCount "0" @default.
- W4385492096 crossrefType "journal-article" @default.
- W4385492096 hasAuthorship W4385492096A5008307109 @default.
- W4385492096 hasAuthorship W4385492096A5012072924 @default.
- W4385492096 hasAuthorship W4385492096A5033441324 @default.
- W4385492096 hasAuthorship W4385492096A5035822981 @default.
- W4385492096 hasAuthorship W4385492096A5039836111 @default.
- W4385492096 hasAuthorship W4385492096A5043031303 @default.
- W4385492096 hasAuthorship W4385492096A5075429312 @default.
- W4385492096 hasAuthorship W4385492096A5085095982 @default.
- W4385492096 hasAuthorship W4385492096A5091161457 @default.
- W4385492096 hasBestOaLocation W43854920961 @default.
- W4385492096 hasConcept C104317684 @default.