Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385492709> ?p ?o ?g. }
- W4385492709 abstract "Inherited metabolic disorders arise from mutations in genes involved in the biogenesis, assembly, or activity of metabolic enzymes, leading to enzymatic deficiency and severe metabolic impairments. Metabolic enzymes are essential for the normal functioning of cells and are involved in the production of amino acids, fatty acids and nucleotides, which are essential for cell growth, division and survival. When the activity of metabolic enzymes is disrupted due to mutations or changes in expression levels, it can result in various metabolic disorders that have also been linked to cancer development. However, there remains much to learn regarding the relationship between the dysregulation of metabolic enzymes and metabolic adaptations in cancer cells. In this review, we explore how dysregulated metabolism due to the alteration or change of metabolic enzymes in cancer cells plays a crucial role in tumor development, progression, metastasis and drug resistance. In addition, these changes in metabolism provide cancer cells with a number of advantages, including increased proliferation, resistance to apoptosis and the ability to evade the immune system. The tumor microenvironment, genetic context, and different signaling pathways further influence this interplay between cancer and metabolism. This review aims to explore how the dysregulation of metabolic enzymes in specific pathways, including the urea cycle, glycogen storage, lysosome storage, fatty acid oxidation, and mitochondrial respiration, contributes to the development of metabolic disorders and cancer. Additionally, the review seeks to shed light on why these enzymes represent crucial potential therapeutic targets and biomarkers in various cancer types." @default.
- W4385492709 created "2023-08-03" @default.
- W4385492709 creator A5007143167 @default.
- W4385492709 creator A5013914918 @default.
- W4385492709 creator A5023356340 @default.
- W4385492709 creator A5032913906 @default.
- W4385492709 date "2023-08-02" @default.
- W4385492709 modified "2023-10-18" @default.
- W4385492709 title "Genetics of enzymatic dysfunctions in metabolic disorders and cancer" @default.
- W4385492709 cites W1205458192 @default.
- W4385492709 cites W124789981 @default.
- W4385492709 cites W142901202 @default.
- W4385492709 cites W1491815634 @default.
- W4385492709 cites W1521381364 @default.
- W4385492709 cites W1588371609 @default.
- W4385492709 cites W1588757601 @default.
- W4385492709 cites W163773482 @default.
- W4385492709 cites W1641843888 @default.
- W4385492709 cites W165497769 @default.
- W4385492709 cites W1829383288 @default.
- W4385492709 cites W1839290653 @default.
- W4385492709 cites W1843927557 @default.
- W4385492709 cites W1857649746 @default.
- W4385492709 cites W1894201636 @default.
- W4385492709 cites W1934207236 @default.
- W4385492709 cites W1963449298 @default.
- W4385492709 cites W1964025113 @default.
- W4385492709 cites W1966821405 @default.
- W4385492709 cites W1967291345 @default.
- W4385492709 cites W1968563981 @default.
- W4385492709 cites W1969931826 @default.
- W4385492709 cites W1970540546 @default.
- W4385492709 cites W1972633518 @default.
- W4385492709 cites W1973092375 @default.
- W4385492709 cites W1973765711 @default.
- W4385492709 cites W1976981476 @default.
- W4385492709 cites W1978680299 @default.
- W4385492709 cites W1978768249 @default.
- W4385492709 cites W1980250100 @default.
- W4385492709 cites W1982026595 @default.
- W4385492709 cites W1982330633 @default.
- W4385492709 cites W1982488143 @default.
- W4385492709 cites W1987197335 @default.
- W4385492709 cites W199204758 @default.
- W4385492709 cites W1994487284 @default.
- W4385492709 cites W1995069275 @default.
- W4385492709 cites W1996185349 @default.
- W4385492709 cites W1997302006 @default.
- W4385492709 cites W1997909822 @default.
- W4385492709 cites W1998654829 @default.
- W4385492709 cites W1999072267 @default.
- W4385492709 cites W2000166251 @default.
- W4385492709 cites W2002029791 @default.
- W4385492709 cites W2002576501 @default.
- W4385492709 cites W2003878114 @default.
- W4385492709 cites W2004174928 @default.
- W4385492709 cites W2010400984 @default.
- W4385492709 cites W2012442095 @default.
- W4385492709 cites W2014321943 @default.
- W4385492709 cites W2017180312 @default.
- W4385492709 cites W2018171566 @default.
- W4385492709 cites W2018571509 @default.
- W4385492709 cites W2018964373 @default.
- W4385492709 cites W2021262975 @default.
- W4385492709 cites W2023300506 @default.
- W4385492709 cites W2028112070 @default.
- W4385492709 cites W2028237627 @default.
- W4385492709 cites W2028687515 @default.
- W4385492709 cites W2029249295 @default.
- W4385492709 cites W2029862112 @default.
- W4385492709 cites W2030595217 @default.
- W4385492709 cites W2030637794 @default.
- W4385492709 cites W2031212829 @default.
- W4385492709 cites W2037173694 @default.
- W4385492709 cites W2037753361 @default.
- W4385492709 cites W2037895641 @default.
- W4385492709 cites W2039461396 @default.
- W4385492709 cites W2040827479 @default.
- W4385492709 cites W2041274762 @default.
- W4385492709 cites W2043382845 @default.
- W4385492709 cites W2045141586 @default.
- W4385492709 cites W2046033277 @default.
- W4385492709 cites W2046100445 @default.
- W4385492709 cites W2047653786 @default.
- W4385492709 cites W2048956955 @default.
- W4385492709 cites W2049416178 @default.
- W4385492709 cites W2051011074 @default.
- W4385492709 cites W2051478776 @default.
- W4385492709 cites W2052329219 @default.
- W4385492709 cites W2052884895 @default.
- W4385492709 cites W2056633943 @default.
- W4385492709 cites W2059747280 @default.
- W4385492709 cites W2060494021 @default.
- W4385492709 cites W2061668475 @default.
- W4385492709 cites W2062006865 @default.
- W4385492709 cites W2063398467 @default.
- W4385492709 cites W2063439260 @default.
- W4385492709 cites W2063540835 @default.
- W4385492709 cites W2064042744 @default.
- W4385492709 cites W2064240900 @default.