Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385494501> ?p ?o ?g. }
- W4385494501 endingPage "145179" @default.
- W4385494501 startingPage "145179" @default.
- W4385494501 abstract "Compared with conventional radiotherapy, ultrahigh dose-rate (FLASH) radiotherapy spares normal tissues through oxygen exhaustion. However, residual cancer stem cells (CSCs) may generate tumour cells, causing tumour recurrence, which represents a critical problem after radiotherapy. Here we developed platelet cell membrane-camouflaged hollow TaOx nanospheres encapsulated with aggregation-induced emission luminogens (AIEgen) (named TPT). With characteristics derived from platelets, TPT nanoparticles (NPs) specifically target tumour regions and enhance FLASH radiotherapy via promoting the photoelectric effect by high Z-element tantalum and elevating reactive oxygen species levels through AIEgen-mediated photodynamic therapy (PDT). Under FLASH radiotherapy, TPT NPs exhibited a remarkable CSC killing effect, significantly inhibiting tumour recurrence. More important, compared with conventional radiotherapy, TPT NPs-promoted FLASH radiotherapy to efficiently eliminate tumours while reducing reoccurrence and severity of complications affecting normal tissues. This strategy provides a novel design to suppress tumour recurrence as well as to avoid adverse side effects." @default.
- W4385494501 created "2023-08-03" @default.
- W4385494501 creator A5001069596 @default.
- W4385494501 creator A5006330226 @default.
- W4385494501 creator A5009119510 @default.
- W4385494501 creator A5012422990 @default.
- W4385494501 creator A5029651470 @default.
- W4385494501 creator A5040776228 @default.
- W4385494501 creator A5047465250 @default.
- W4385494501 creator A5059727533 @default.
- W4385494501 creator A5073822569 @default.
- W4385494501 creator A5084108321 @default.
- W4385494501 date "2023-10-01" @default.
- W4385494501 modified "2023-10-14" @default.
- W4385494501 title "AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects" @default.
- W4385494501 cites W1484334610 @default.
- W4385494501 cites W1912124796 @default.
- W4385494501 cites W1992406775 @default.
- W4385494501 cites W2020535635 @default.
- W4385494501 cites W2052077274 @default.
- W4385494501 cites W2067067209 @default.
- W4385494501 cites W2079641266 @default.
- W4385494501 cites W2082639976 @default.
- W4385494501 cites W2096456517 @default.
- W4385494501 cites W2134025982 @default.
- W4385494501 cites W2401893904 @default.
- W4385494501 cites W2468320141 @default.
- W4385494501 cites W2491502780 @default.
- W4385494501 cites W2793362992 @default.
- W4385494501 cites W2805362264 @default.
- W4385494501 cites W2809035003 @default.
- W4385494501 cites W2809876783 @default.
- W4385494501 cites W2886654672 @default.
- W4385494501 cites W2913631356 @default.
- W4385494501 cites W2913798055 @default.
- W4385494501 cites W2946753897 @default.
- W4385494501 cites W2950056753 @default.
- W4385494501 cites W2955294253 @default.
- W4385494501 cites W2957222805 @default.
- W4385494501 cites W2967873149 @default.
- W4385494501 cites W2972802464 @default.
- W4385494501 cites W2980003399 @default.
- W4385494501 cites W2987505784 @default.
- W4385494501 cites W2990348639 @default.
- W4385494501 cites W2996099489 @default.
- W4385494501 cites W3002119942 @default.
- W4385494501 cites W3014416586 @default.
- W4385494501 cites W3016220656 @default.
- W4385494501 cites W3034985463 @default.
- W4385494501 cites W3045888043 @default.
- W4385494501 cites W3087180691 @default.
- W4385494501 cites W3092883299 @default.
- W4385494501 cites W3095550317 @default.
- W4385494501 cites W3126025248 @default.
- W4385494501 cites W3127352399 @default.
- W4385494501 cites W3155711700 @default.
- W4385494501 cites W3162627671 @default.
- W4385494501 cites W3164658958 @default.
- W4385494501 cites W3169912805 @default.
- W4385494501 cites W3177225755 @default.
- W4385494501 cites W3185044860 @default.
- W4385494501 cites W4214748203 @default.
- W4385494501 cites W4220846326 @default.
- W4385494501 cites W4221034214 @default.
- W4385494501 cites W4280489835 @default.
- W4385494501 doi "https://doi.org/10.1016/j.cej.2023.145179" @default.
- W4385494501 hasPublicationYear "2023" @default.
- W4385494501 type Work @default.
- W4385494501 citedByCount "0" @default.
- W4385494501 crossrefType "journal-article" @default.
- W4385494501 hasAuthorship W4385494501A5001069596 @default.
- W4385494501 hasAuthorship W4385494501A5006330226 @default.
- W4385494501 hasAuthorship W4385494501A5009119510 @default.
- W4385494501 hasAuthorship W4385494501A5012422990 @default.
- W4385494501 hasAuthorship W4385494501A5029651470 @default.
- W4385494501 hasAuthorship W4385494501A5040776228 @default.
- W4385494501 hasAuthorship W4385494501A5047465250 @default.
- W4385494501 hasAuthorship W4385494501A5059727533 @default.
- W4385494501 hasAuthorship W4385494501A5073822569 @default.
- W4385494501 hasAuthorship W4385494501A5084108321 @default.
- W4385494501 hasConcept C111337013 @default.
- W4385494501 hasConcept C121332964 @default.
- W4385494501 hasConcept C141071460 @default.
- W4385494501 hasConcept C142362112 @default.
- W4385494501 hasConcept C153349607 @default.
- W4385494501 hasConcept C178790620 @default.
- W4385494501 hasConcept C185544564 @default.
- W4385494501 hasConcept C185592680 @default.
- W4385494501 hasConcept C2777526259 @default.
- W4385494501 hasConcept C2781323092 @default.
- W4385494501 hasConcept C48349386 @default.
- W4385494501 hasConcept C502942594 @default.
- W4385494501 hasConcept C509974204 @default.
- W4385494501 hasConcept C55493867 @default.
- W4385494501 hasConcept C71924100 @default.
- W4385494501 hasConceptScore W4385494501C111337013 @default.
- W4385494501 hasConceptScore W4385494501C121332964 @default.
- W4385494501 hasConceptScore W4385494501C141071460 @default.