FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385494820> ?p ?o ?g. }

• W4385494820 endingPage "631" @default.
• W4385494820 startingPage "622" @default.
• W4385494820 abstract "In Japan, only single-unit cord blood transplantations (CBTs) are typically performed, and their number has increased over the last 23 years, with ongoing improvement in results. In most cases, CBTs with multiple HLA mismatches are used, owing to a low HLA barrier, and lower engraftment rate is a problem that must be overcome. Here, as part of an effort to improve guidelines for the selection and processing of CB units for transplantation, we sought to assess the present status of CBT in Japan and to elucidate factors contributing to the favorable outcomes, focusing in particular on selection by cell components of CB unit and HLA allele matching. We conducted a nationwide study analyzing 13,443 patients who underwent first CBT between in Japan between December 1997 and December 2019 using multivariate regression analysis. Both patient- and transplantation-related variables, such as age and Hematopoietic Cell Transplantation Comorbidity Index, as well as selected CB unit characteristics, were included in the analysis. The interaction analysis elucidated that CB unit selection favoring higher counts of CD34+ cells and granulocyte macrophage colony-forming units (GM-CFU)/kg, but not of total nucleated cells, contributed to improved engraftment after transplantation. Moreover, a higher CD34+ cell dose was associated with improved overall survival (OS). Distinctive HLA allele matching was observed. A 0 or 1 HLA allele mismatch between patient and donor had favorable engraftment and carried significantly lower risks of acute GVHD and chronic GVHD but had a significantly higher leukemia relapse rate, compared with a 3-HLA allele mismatch. HLA-DRB1 mismatches were associated with reduced risk of leukemia relapse. Notably, the number of HLA allele mismatches had no incremental effect on engraftment, acute and chronic GVHD, or relapse incidence. As a result, 5-year overall survival did not differ significantly among patients receiving CB units with 0 to 7 HLA allele mismatches. The main points of CB unit selection are as follows. First, selection according to a higher number of CD34+ cells/kg and then of CFU-GM/kg is recommended to obtain favorable engraftment. A unit with .5 × 105 CD34+ cells/kg is minimally acceptable. For units with a CD34+ cell dose of .5 to 1.0 × 105 cells/kg, applying the parameter of ≥20 to 50 × 103 GM-CFU/kg (66.5% of transplanted CB units in this cohort) is associated with a neutrophil engraftment rate of approximately 90%. A unit with ≥1.0 × 105 CD34+ cells/kg can achieve a ≥90% mean neutrophil engraftment rate. Subsequently, HLA allele matching of HLA-A, -B, -C, and -DRB1 at the 2-field level should be searched for units with 0 or 1 HLA allele mismatch in the host-versus-graft direction for favorable engraftment. Units with 2 to 6 HLA allele mismatches are acceptable in patients age ≥15 years and units with 2 to 4 HLA allele mismatches are acceptable in patients age ≤14 years. Units with HLA-DRB1 and/or -B allele mismatch(es) might not be preferable owing to an increased GVHD risk. Our analysis demonstrates that single-unit CBT with the selection of adequate CD34+/kg and GM-CFU/kg and HLA allele matching showed favorable outcomes in both pediatric and adult patients." @default.
• W4385494820 created "2023-08-03" @default.
• W4385494820 creator A5004509292 @default.
• W4385494820 creator A5007951151 @default.
• W4385494820 creator A5011288768 @default.
• W4385494820 creator A5022118265 @default.
• W4385494820 creator A5023036531 @default.
• W4385494820 creator A5023573848 @default.
• W4385494820 creator A5027656839 @default.
• W4385494820 creator A5031325837 @default.
• W4385494820 creator A5034553302 @default.
• W4385494820 creator A5036726875 @default.
• W4385494820 creator A5043392594 @default.
• W4385494820 creator A5046989635 @default.
• W4385494820 creator A5047706264 @default.
• W4385494820 creator A5049851838 @default.
• W4385494820 creator A5050448276 @default.
• W4385494820 creator A5052125683 @default.
• W4385494820 creator A5064928700 @default.
• W4385494820 creator A5065323653 @default.
• W4385494820 creator A5069791653 @default.
• W4385494820 creator A5071572385 @default.
• W4385494820 creator A5072163593 @default.
• W4385494820 creator A5072808833 @default.
• W4385494820 creator A5074346318 @default.
• W4385494820 creator A5078789114 @default.
• W4385494820 creator A5087642726 @default.
• W4385494820 creator A5092583516 @default.
• W4385494820 date "2023-10-01" @default.
• W4385494820 modified "2023-10-13" @default.
• W4385494820 title "Selection of Cord Blood Unit by CD34+ Cell and GM-CFU Numbers and Allele-Level HLA Matching in Single Cord Blood Transplantation" @default.
• W4385494820 cites W1966342001 @default.
• W4385494820 cites W1973881356 @default.
• W4385494820 cites W2007696527 @default.
• W4385494820 cites W2017069859 @default.
• W4385494820 cites W2021840885 @default.
• W4385494820 cites W2030621192 @default.
• W4385494820 cites W2142467765 @default.
• W4385494820 cites W2165480626 @default.
• W4385494820 cites W2190125394 @default.
• W4385494820 cites W2604230957 @default.
• W4385494820 cites W2728620617 @default.
• W4385494820 cites W2807389995 @default.
• W4385494820 cites W2946845316 @default.
• W4385494820 cites W2961599785 @default.
• W4385494820 cites W2987975197 @default.
• W4385494820 cites W2995115235 @default.
• W4385494820 cites W3045923563 @default.
• W4385494820 cites W3082296557 @default.
• W4385494820 cites W3131246988 @default.
• W4385494820 cites W3160072398 @default.
• W4385494820 cites W3181009913 @default.
• W4385494820 cites W3209099042 @default.
• W4385494820 cites W4206417809 @default.
• W4385494820 cites W4280540055 @default.
• W4385494820 cites W4307989370 @default.
• W4385494820 doi "https://doi.org/10.1016/j.jtct.2023.07.022" @default.
• W4385494820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37536453" @default.
• W4385494820 hasPublicationYear "2023" @default.
• W4385494820 type Work @default.
• W4385494820 citedByCount "0" @default.
• W4385494820 crossrefType "journal-article" @default.
• W4385494820 hasAuthorship W4385494820A5004509292 @default.
• W4385494820 hasAuthorship W4385494820A5007951151 @default.
• W4385494820 hasAuthorship W4385494820A5011288768 @default.
• W4385494820 hasAuthorship W4385494820A5022118265 @default.
• W4385494820 hasAuthorship W4385494820A5023036531 @default.
• W4385494820 hasAuthorship W4385494820A5023573848 @default.
• W4385494820 hasAuthorship W4385494820A5027656839 @default.
• W4385494820 hasAuthorship W4385494820A5031325837 @default.
• W4385494820 hasAuthorship W4385494820A5034553302 @default.
• W4385494820 hasAuthorship W4385494820A5036726875 @default.
• W4385494820 hasAuthorship W4385494820A5043392594 @default.
• W4385494820 hasAuthorship W4385494820A5046989635 @default.
• W4385494820 hasAuthorship W4385494820A5047706264 @default.
• W4385494820 hasAuthorship W4385494820A5049851838 @default.
• W4385494820 hasAuthorship W4385494820A5050448276 @default.
• W4385494820 hasAuthorship W4385494820A5052125683 @default.
• W4385494820 hasAuthorship W4385494820A5064928700 @default.
• W4385494820 hasAuthorship W4385494820A5065323653 @default.
• W4385494820 hasAuthorship W4385494820A5069791653 @default.
• W4385494820 hasAuthorship W4385494820A5071572385 @default.
• W4385494820 hasAuthorship W4385494820A5072163593 @default.
• W4385494820 hasAuthorship W4385494820A5072808833 @default.
• W4385494820 hasAuthorship W4385494820A5074346318 @default.
• W4385494820 hasAuthorship W4385494820A5078789114 @default.
• W4385494820 hasAuthorship W4385494820A5087642726 @default.
• W4385494820 hasAuthorship W4385494820A5092583516 @default.
• W4385494820 hasBestOaLocation W43854948201 @default.
• W4385494820 hasConcept C10205521 @default.
• W4385494820 hasConcept C104317684 @default.
• W4385494820 hasConcept C126322002 @default.
• W4385494820 hasConcept C143998085 @default.
• W4385494820 hasConcept C147483822 @default.
• W4385494820 hasConcept C180754005 @default.
• W4385494820 hasConcept C188280979 @default.
• W4385494820 hasConcept C203014093 @default.
• W4385494820 hasConcept C2777408962 @default.

• next