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- W4385496786 endingPage "104085" @default.
- W4385496786 startingPage "104085" @default.
- W4385496786 abstract "Mantle cell lymphoma (MCL) is a rare, aggressive subtype of non-Hodgkin’s lymphoma (NHL), accounting for 5% of all cases. Due to its virulence factor, it is an incurable disease and keeps relapsing despite an intensive treatment regimen. Advancements in research and drug discovery have shifted the treatment strategy from conventional chemotherapy to targeted agents and immunotherapies. The establishment of the role of Bruton tyrosine kinase led to the development of ibrutinib, a first-generation BTK inhibitor, and its successors. A conditioning regimen based immunotherapeutic agent like ibritumumob, has also demonstrated a viable response with a favorable toxicity profile. Brexucabtagene Autoleucel, the only approved CAR T-cell therapy, has proven advantageous for relapsed/refractory MCL in both children and adults. This article reviews certain therapies that could help update the current approach and summarizes a few miscellaneous agents, which, seldom studied in trials, could alleviate the regression observed in traditional therapies. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request." @default.
- W4385496786 created "2023-08-03" @default.
- W4385496786 creator A5001367208 @default.
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- W4385496786 creator A5065172079 @default.
- W4385496786 creator A5075530875 @default.
- W4385496786 creator A5092071025 @default.
- W4385496786 date "2023-10-01" @default.
- W4385496786 modified "2023-10-17" @default.
- W4385496786 title "Combating relapsed and refractory Mantle cell lymphoma with novel therapeutic armamentarium: Recent advances and clinical prospects" @default.
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- W4385496786 doi "https://doi.org/10.1016/j.critrevonc.2023.104085" @default.
- W4385496786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37536448" @default.
- W4385496786 hasPublicationYear "2023" @default.