Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385500535> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W4385500535 abstract "To compare the preimplantation genetic testing for aneuploidy (PGT-A) results using the three most frequent criteria employed by preimplantation genetic laboratories and evaluate its impact on the number of euploid embryos available for transfer.Retrospective and descriptive study including patients who underwent PGT-A between January 2018 and December 2020. Five hundred and nine PGT-A cycles and 2,079 blastocysts were analyzed by next-generation sequencing (NGS). We re-assigned the diagnosis of all blastocysts using three different criteria: strict (mosaicism thresholds from 20% to 80%), standard (from 30% to 70%) and excluding (mosaicism is not reported). We compared the euploid, aneuploid and mosaic embryos obtained in each criteria used.We observed PGT-A results discrepancies in 32.5% (165/509) of the cycles when the three different criteria were applied. The standard and excluding criteria showed 92 more euploid embryos (875/2,079) compared to the strict criteria (783/2,079). Evaluating the PGT-A results per cycle with the strict, standard and excluding criteria, the euploidy rates were 34.0%, 38.4% and 38.4% (p<0.001); aneuploidy rates were 59.0%, 55.8% and 61.6% (p<0.001) and mosaic rates were 7.0% and 5.8% (p<0.047), respectively. The mean number of euploid blastocysts available for transfer was 1.54±1.67 with the strict criteria, while the possibility to obtain an euploid embryo was higher if the standard or the excluding criteria were used 1.72±1.78 (p<0.001).This study highlights the importance of standardizing the criteria used for the interpretation of PGT-A blastocysts. We observed significant differences on PGT-A results associated solely to the criteria used." @default.
- W4385500535 created "2023-08-03" @default.
- W4385500535 creator A5007570351 @default.
- W4385500535 creator A5015555538 @default.
- W4385500535 creator A5026771664 @default.
- W4385500535 creator A5041919857 @default.
- W4385500535 creator A5076203145 @default.
- W4385500535 date "2023-01-01" @default.
- W4385500535 modified "2023-10-02" @default.
- W4385500535 title "The importance of standardizing criteria for PGT-A interpretation of blastocysts analyzed by next-generation sequencing" @default.
- W4385500535 doi "https://doi.org/10.5935/1518-0557.20230011" @default.
- W4385500535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37579264" @default.
- W4385500535 hasPublicationYear "2023" @default.
- W4385500535 type Work @default.
- W4385500535 citedByCount "0" @default.
- W4385500535 crossrefType "journal-article" @default.
- W4385500535 hasAuthorship W4385500535A5007570351 @default.
- W4385500535 hasAuthorship W4385500535A5015555538 @default.
- W4385500535 hasAuthorship W4385500535A5026771664 @default.
- W4385500535 hasAuthorship W4385500535A5041919857 @default.
- W4385500535 hasAuthorship W4385500535A5076203145 @default.
- W4385500535 hasBestOaLocation W43855005351 @default.
- W4385500535 hasConcept C104317684 @default.
- W4385500535 hasConcept C143191323 @default.
- W4385500535 hasConcept C160099875 @default.
- W4385500535 hasConcept C16685009 @default.
- W4385500535 hasConcept C196843134 @default.
- W4385500535 hasConcept C2779672484 @default.
- W4385500535 hasConcept C2780673598 @default.
- W4385500535 hasConcept C29456083 @default.
- W4385500535 hasConcept C30481170 @default.
- W4385500535 hasConcept C54355233 @default.
- W4385500535 hasConcept C71924100 @default.
- W4385500535 hasConcept C86803240 @default.
- W4385500535 hasConceptScore W4385500535C104317684 @default.
- W4385500535 hasConceptScore W4385500535C143191323 @default.
- W4385500535 hasConceptScore W4385500535C160099875 @default.
- W4385500535 hasConceptScore W4385500535C16685009 @default.
- W4385500535 hasConceptScore W4385500535C196843134 @default.
- W4385500535 hasConceptScore W4385500535C2779672484 @default.
- W4385500535 hasConceptScore W4385500535C2780673598 @default.
- W4385500535 hasConceptScore W4385500535C29456083 @default.
- W4385500535 hasConceptScore W4385500535C30481170 @default.
- W4385500535 hasConceptScore W4385500535C54355233 @default.
- W4385500535 hasConceptScore W4385500535C71924100 @default.
- W4385500535 hasConceptScore W4385500535C86803240 @default.
- W4385500535 hasLocation W43855005351 @default.
- W4385500535 hasLocation W43855005352 @default.
- W4385500535 hasOpenAccess W4385500535 @default.
- W4385500535 hasPrimaryLocation W43855005351 @default.
- W4385500535 hasRelatedWork W2061592832 @default.
- W4385500535 hasRelatedWork W2151535125 @default.
- W4385500535 hasRelatedWork W2183685009 @default.
- W4385500535 hasRelatedWork W2474189928 @default.
- W4385500535 hasRelatedWork W2509202055 @default.
- W4385500535 hasRelatedWork W2513703644 @default.
- W4385500535 hasRelatedWork W318902238 @default.
- W4385500535 hasRelatedWork W4220678844 @default.
- W4385500535 hasRelatedWork W4307398699 @default.
- W4385500535 hasRelatedWork W4319601417 @default.
- W4385500535 hasVolume "27" @default.
- W4385500535 isParatext "false" @default.
- W4385500535 isRetracted "false" @default.
- W4385500535 workType "article" @default.