SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385500583> ?p ?o ?g. }

Showing items 1 to 100 of ±179 with 100 items per page.

W4385500583 endingPage "0" @default.
W4385500583 startingPage "0" @default.
W4385500583 abstract "The mitochondrial adaptor protein p66Shc has been suggested to control life span in mice via the release of hydrogen peroxide. However, the role of p66Shc in lung aging remains unsolved. Thus, we investigated the effects of p66Shc-/- on the aging of the lung and pulmonary circulation. In vivo lung and cardiac characteristics were investigated in p66Shc-/- and wild type (WT) mice at 3, 12, and 24 months of age by lung function measurements, micro-computed tomography (µCT), and echocardiography. Alveolar number and muscularization of small pulmonary arteries were measured by stereology and vascular morphometry, respectively. Protein and mRNA levels of senescent markers were measured by western blot and PCR, respectively. Lung function declined similarly in WT and p66Shc-/- mice during aging. However, µCT analyses and stereology showed slightly enhanced signs of aging-related parameters in p66Shc-/- mice, such as a decline of alveolar density. Accordingly, p66Shc-/- mice showed higher protein expression of the senescence marker p21 in lung homogenate compared to WT mice of the corresponding age. Pulmonary vascular remodeling was increased during aging, but aged p66Shc-/- mice showed similar muscularization of pulmonary vessels and hemodynamics like WT mice. In the heart, p66Shc-/- prevented the deterioration of right ventricular (RV) function but promoted the decline of left ventricular (LV) function during aging. p66Shc-/- affects the aging process of the lung and the heart differently. While p66Shc-/- slightly accelerates lung aging and deteriorates LV function in aged mice, it seems to exert protective effects on RV function during aging." @default.
W4385500583 created "2023-08-03" @default.
W4385500583 creator A5000925780 @default.
W4385500583 creator A5012081620 @default.
W4385500583 creator A5014810915 @default.
W4385500583 creator A5016511599 @default.
W4385500583 creator A5018282864 @default.
W4385500583 creator A5020892711 @default.
W4385500583 creator A5027844393 @default.
W4385500583 creator A5039470820 @default.
W4385500583 creator A5040596273 @default.
W4385500583 creator A5041650670 @default.
W4385500583 creator A5044036919 @default.
W4385500583 creator A5045795242 @default.
W4385500583 creator A5047185790 @default.
W4385500583 creator A5050068072 @default.
W4385500583 creator A5054741120 @default.
W4385500583 creator A5057524424 @default.
W4385500583 creator A5061922297 @default.
W4385500583 creator A5063948628 @default.
W4385500583 creator A5066630882 @default.
W4385500583 creator A5077984224 @default.
W4385500583 creator A5085910452 @default.
W4385500583 date "2023-01-01" @default.
W4385500583 modified "2023-10-16" @default.
W4385500583 title "The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung" @default.
W4385500583 cites W1527208294 @default.
W4385500583 cites W1581119831 @default.
W4385500583 cites W1963492502 @default.
W4385500583 cites W1973819651 @default.
W4385500583 cites W1975425330 @default.
W4385500583 cites W1977466215 @default.
W4385500583 cites W1978765985 @default.
W4385500583 cites W1984119045 @default.
W4385500583 cites W1985191673 @default.
W4385500583 cites W1985939862 @default.
W4385500583 cites W2002285022 @default.
W4385500583 cites W2010345740 @default.
W4385500583 cites W2011061983 @default.
W4385500583 cites W2014320407 @default.
W4385500583 cites W2017109096 @default.
W4385500583 cites W2018762529 @default.
W4385500583 cites W2027757538 @default.
W4385500583 cites W2069049877 @default.
W4385500583 cites W2072632902 @default.
W4385500583 cites W2085507409 @default.
W4385500583 cites W2089939834 @default.
W4385500583 cites W2098774492 @default.
W4385500583 cites W2106087363 @default.
W4385500583 cites W2108433881 @default.
W4385500583 cites W2108606652 @default.
W4385500583 cites W2111555939 @default.
W4385500583 cites W2112821970 @default.
W4385500583 cites W2116132659 @default.
W4385500583 cites W2118685612 @default.
W4385500583 cites W2120992354 @default.
W4385500583 cites W2126437028 @default.
W4385500583 cites W2126525177 @default.
W4385500583 cites W2127019230 @default.
W4385500583 cites W2131760736 @default.
W4385500583 cites W2135564059 @default.
W4385500583 cites W2140715357 @default.
W4385500583 cites W2141473890 @default.
W4385500583 cites W2150381945 @default.
W4385500583 cites W2154674926 @default.
W4385500583 cites W2159267296 @default.
W4385500583 cites W2165209574 @default.
W4385500583 cites W2298374653 @default.
W4385500583 cites W2350256796 @default.
W4385500583 cites W2514976058 @default.
W4385500583 cites W2529018438 @default.
W4385500583 cites W2545291971 @default.
W4385500583 cites W2566497735 @default.
W4385500583 cites W2745829392 @default.
W4385500583 cites W2763064787 @default.
W4385500583 cites W2790056846 @default.
W4385500583 cites W2793162099 @default.
W4385500583 cites W2793813495 @default.
W4385500583 cites W2793973847 @default.
W4385500583 cites W2863641411 @default.
W4385500583 cites W2885146792 @default.
W4385500583 cites W2912918280 @default.
W4385500583 cites W2943719207 @default.
W4385500583 cites W2984453596 @default.
W4385500583 cites W2994149938 @default.
W4385500583 cites W2995236678 @default.
W4385500583 cites W3004351868 @default.
W4385500583 cites W3012000971 @default.
W4385500583 cites W3023273411 @default.
W4385500583 cites W3033336738 @default.
W4385500583 cites W3040876684 @default.
W4385500583 cites W3110707167 @default.
W4385500583 cites W3117139588 @default.
W4385500583 cites W3139352635 @default.
W4385500583 cites W3158645268 @default.
W4385500583 cites W3184166930 @default.
W4385500583 cites W3199374161 @default.
W4385500583 cites W4206751626 @default.