Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385500752> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W4385500752 abstract "Background: Colorectal carcinoma (CRC) is the most common and one of the main causes of mortality and morbidity globally among gastrointestinal tract tumors. A benign polyp is the first step in the multistage pathogenesis of colorectal cancer, which eventually progresses to an adenoma and a carcinoma. Wnt/ βeta-catenin signaling pathway plays an initiating and rate-limiting role in colorectal tumorigenesis. Aim of the work: To evaluate the association between the immunohistochemistry (expression of E-cadherin, and β-catenin with the histopathological grade, and stage of colorectal cancer. Materials and Methods: The study was retrospectively collected from the archives of the Department of Pathology in Tobruk Medical Center. Eighty-two histopathologically confirmed cases of adenomas (n = 48) (tubular, villous, and tubulovillous), and colorectal adenocarcinoma (Mucinous, and Non-mucinous) (n = 34) were included in this study over two years (2021-2023). The histopathological diagnosis, grade, and staging of the tumors were obtained. While clinical information was obtained from medical records and pathology reports. immunohistochemical staining was performed for all the cases using E-cadherin and β-catenin antibodies, and the results were analyzed. Results: A total of 82 patients were studied out of these, 51(62.2%) patients were male, whereas 31 (37.8%) were females with a male: female ratio of 1.6:1. Age ranged from 30 years to 80 years. The mean age was the mean age of 52.9 (SD±15.8). A high prevalence of adenoma cases was observed in the age group 30– 40 years. The peak incidence for both types of colorectal carcinoma was in 61-70 years. By scoring the intensity of β-catenin there are significant correlation of β-catenin expression with tumor grade, stage, lymph node metastasis, and types of adenomas. The intensity of staining of E-cadherin in 48 cases of adenomas was showing high expression in 39 cases (81.3%), and low expression in only 9 cases (18.7%). While, the majority of the patients with CRC (58.8%) had low expression of E-cadherin levels, and (41.2%) had high expression. Conclusion: Our findings imply that E-cadherin and β-catenin may contribute to the invasion and progression of colorectal cancer, which may serve as prognostic indicators for colorectal carcinoma" @default.
- W4385500752 created "2023-08-03" @default.
- W4385500752 creator A5005603991 @default.
- W4385500752 creator A5007040206 @default.
- W4385500752 date "2023-01-01" @default.
- W4385500752 modified "2023-09-27" @default.
- W4385500752 title "Wnt signaling-associated proteins, β-catenin, and E-cadherin as a potential immunohistochemical bi-omarker of the progression of adenoma to colorectal carcinoma" @default.
- W4385500752 doi "https://doi.org/10.18103/mra.v11i7.2.4155" @default.
- W4385500752 hasPublicationYear "2023" @default.
- W4385500752 type Work @default.
- W4385500752 citedByCount "0" @default.
- W4385500752 crossrefType "journal-article" @default.
- W4385500752 hasAuthorship W4385500752A5005603991 @default.
- W4385500752 hasAuthorship W4385500752A5007040206 @default.
- W4385500752 hasBestOaLocation W43855007521 @default.
- W4385500752 hasConcept C120665830 @default.
- W4385500752 hasConcept C121332964 @default.
- W4385500752 hasConcept C121608353 @default.
- W4385500752 hasConcept C126322002 @default.
- W4385500752 hasConcept C137620995 @default.
- W4385500752 hasConcept C142724271 @default.
- W4385500752 hasConcept C143998085 @default.
- W4385500752 hasConcept C204232928 @default.
- W4385500752 hasConcept C2776861080 @default.
- W4385500752 hasConcept C2777428134 @default.
- W4385500752 hasConcept C2777936439 @default.
- W4385500752 hasConcept C2778435480 @default.
- W4385500752 hasConcept C2781182431 @default.
- W4385500752 hasConcept C526805850 @default.
- W4385500752 hasConcept C55493867 @default.
- W4385500752 hasConcept C61511704 @default.
- W4385500752 hasConcept C62478195 @default.
- W4385500752 hasConcept C71924100 @default.
- W4385500752 hasConcept C86803240 @default.
- W4385500752 hasConcept C90924648 @default.
- W4385500752 hasConceptScore W4385500752C120665830 @default.
- W4385500752 hasConceptScore W4385500752C121332964 @default.
- W4385500752 hasConceptScore W4385500752C121608353 @default.
- W4385500752 hasConceptScore W4385500752C126322002 @default.
- W4385500752 hasConceptScore W4385500752C137620995 @default.
- W4385500752 hasConceptScore W4385500752C142724271 @default.
- W4385500752 hasConceptScore W4385500752C143998085 @default.
- W4385500752 hasConceptScore W4385500752C204232928 @default.
- W4385500752 hasConceptScore W4385500752C2776861080 @default.
- W4385500752 hasConceptScore W4385500752C2777428134 @default.
- W4385500752 hasConceptScore W4385500752C2777936439 @default.
- W4385500752 hasConceptScore W4385500752C2778435480 @default.
- W4385500752 hasConceptScore W4385500752C2781182431 @default.
- W4385500752 hasConceptScore W4385500752C526805850 @default.
- W4385500752 hasConceptScore W4385500752C55493867 @default.
- W4385500752 hasConceptScore W4385500752C61511704 @default.
- W4385500752 hasConceptScore W4385500752C62478195 @default.
- W4385500752 hasConceptScore W4385500752C71924100 @default.
- W4385500752 hasConceptScore W4385500752C86803240 @default.
- W4385500752 hasConceptScore W4385500752C90924648 @default.
- W4385500752 hasIssue "7.2" @default.
- W4385500752 hasLocation W43855007521 @default.
- W4385500752 hasOpenAccess W4385500752 @default.
- W4385500752 hasPrimaryLocation W43855007521 @default.
- W4385500752 hasRelatedWork W1968942241 @default.
- W4385500752 hasRelatedWork W2092312772 @default.
- W4385500752 hasRelatedWork W2348725138 @default.
- W4385500752 hasRelatedWork W2381664783 @default.
- W4385500752 hasRelatedWork W2388629598 @default.
- W4385500752 hasRelatedWork W2429678505 @default.
- W4385500752 hasRelatedWork W2885536099 @default.
- W4385500752 hasRelatedWork W2896077670 @default.
- W4385500752 hasRelatedWork W2990285129 @default.
- W4385500752 hasRelatedWork W3030821022 @default.
- W4385500752 hasVolume "11" @default.
- W4385500752 isParatext "false" @default.
- W4385500752 isRetracted "false" @default.
- W4385500752 workType "article" @default.