Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385501632> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4385501632 endingPage "2566" @default.
- W4385501632 startingPage "2563" @default.
- W4385501632 abstract "Background: Ofatumumab (OFA) is a fully human anti-CD20 monoclonal antibody administered with a 20 mg subcutaneous monthly dosing regimen. Methods: Inclusion criteria were patients: 1) aged 18-55; 2) with a confirmed diagnosis of relapsing Multiple Sclerosis (RMS), per the revised 2010 McDonald criteria; 2) who started OFA according to Italian Medicines Agency prescription rules and within 12 months from the RMS diagnosis; 3) naïve to any disease-modifying therapy. The primary outcome was to offer an overview of cellular subsets of RMS naïve patients (time 0) and then after 4 weeks (time 1) and 12 weeks (time 2) on therapy with OFA in a real-world setting. Results: Fifteen patients were enrolled. CD3+ T cell frequencies were higher at time 1 (%80.4, SD 7.7) and time 2 (%82.6, SD 5.8) when compared to time 0 (%72.4, SD 9.8), p = .013. B naïve cells were barely detectable in the OFA group at time 1 (%0.4, SD 0.5) and 2 (%1.4, SD 2.9) when compared to time 0 (%11.5, SD 3.8), p < .001. Conclusion: The progressive and increasing use of anti-CD20 drugs imposes the need for larger, prospective, real-world, long-term studies to characterize further immunophenotypes of patients with RMS treated with OFA." @default.
- W4385501632 created "2023-08-03" @default.
- W4385501632 creator A5001899447 @default.
- W4385501632 creator A5002696966 @default.
- W4385501632 creator A5024279876 @default.
- W4385501632 creator A5026883535 @default.
- W4385501632 creator A5062156098 @default.
- W4385501632 date "2023-12-01" @default.
- W4385501632 modified "2023-10-05" @default.
- W4385501632 title "Ofatumumab and Early Immunological Cells Subset Characterization in Naïve Relapsing Multiple Sclerosis Patients: A Real-World Study" @default.
- W4385501632 doi "https://doi.org/10.2174/1570159x21666230803161825" @default.
- W4385501632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534789" @default.
- W4385501632 hasPublicationYear "2023" @default.
- W4385501632 type Work @default.
- W4385501632 citedByCount "0" @default.
- W4385501632 crossrefType "journal-article" @default.
- W4385501632 hasAuthorship W4385501632A5001899447 @default.
- W4385501632 hasAuthorship W4385501632A5002696966 @default.
- W4385501632 hasAuthorship W4385501632A5024279876 @default.
- W4385501632 hasAuthorship W4385501632A5026883535 @default.
- W4385501632 hasAuthorship W4385501632A5062156098 @default.
- W4385501632 hasConcept C126322002 @default.
- W4385501632 hasConcept C159654299 @default.
- W4385501632 hasConcept C18031839 @default.
- W4385501632 hasConcept C203014093 @default.
- W4385501632 hasConcept C2777288759 @default.
- W4385501632 hasConcept C2778714382 @default.
- W4385501632 hasConcept C2778843634 @default.
- W4385501632 hasConcept C2780640218 @default.
- W4385501632 hasConcept C2780653079 @default.
- W4385501632 hasConcept C2781413609 @default.
- W4385501632 hasConcept C71924100 @default.
- W4385501632 hasConcept C90924648 @default.
- W4385501632 hasConceptScore W4385501632C126322002 @default.
- W4385501632 hasConceptScore W4385501632C159654299 @default.
- W4385501632 hasConceptScore W4385501632C18031839 @default.
- W4385501632 hasConceptScore W4385501632C203014093 @default.
- W4385501632 hasConceptScore W4385501632C2777288759 @default.
- W4385501632 hasConceptScore W4385501632C2778714382 @default.
- W4385501632 hasConceptScore W4385501632C2778843634 @default.
- W4385501632 hasConceptScore W4385501632C2780640218 @default.
- W4385501632 hasConceptScore W4385501632C2780653079 @default.
- W4385501632 hasConceptScore W4385501632C2781413609 @default.
- W4385501632 hasConceptScore W4385501632C71924100 @default.
- W4385501632 hasConceptScore W4385501632C90924648 @default.
- W4385501632 hasIssue "12" @default.
- W4385501632 hasLocation W43855016321 @default.
- W4385501632 hasLocation W43855016322 @default.
- W4385501632 hasOpenAccess W4385501632 @default.
- W4385501632 hasPrimaryLocation W43855016321 @default.
- W4385501632 hasRelatedWork W2272446420 @default.
- W4385501632 hasRelatedWork W2511874056 @default.
- W4385501632 hasRelatedWork W2908850704 @default.
- W4385501632 hasRelatedWork W2971869275 @default.
- W4385501632 hasRelatedWork W3093955355 @default.
- W4385501632 hasRelatedWork W3206036626 @default.
- W4385501632 hasRelatedWork W3206160011 @default.
- W4385501632 hasRelatedWork W4285384838 @default.
- W4385501632 hasRelatedWork W4360619161 @default.
- W4385501632 hasRelatedWork W4362458038 @default.
- W4385501632 hasVolume "21" @default.
- W4385501632 isParatext "false" @default.
- W4385501632 isRetracted "false" @default.
- W4385501632 workType "article" @default.