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• W4385506105 abstract "Objectives Patients hospitalized with stroke develop delirium at higher rates than general hospitalized patients. While several medications are associated with existing delirium, it is unknown whether early medication exposures are associated with subsequent delirium in patients with stroke. Additionally, it is unknown whether delirium identification is associated with changes in the prescription of these medications. Materials and methods We conducted a retrospective cohort study of patients admitted to a comprehensive stroke center, who were assessed for delirium by trained nursing staff during clinical care. We analyzed exposures to multiple medication classes in the first 48 h of admission, and compared them between patients who developed delirium >48 hours after admission and those who never developed delirium. Statistical analysis was performed using univariate testing. Multivariable logistic regression was used further to evaluate the significance of univariately significant medications, while controlling for clinical confounders. Results 1671 unique patients were included in the cohort, of whom 464 (27.8%) developed delirium >48 hours after admission. Delirium was associated with prior exposure to antipsychotics, sedatives, opiates, and antimicrobials. Antipsychotics, sedatives, and antimicrobials remained significantly associated with delirium even after accounting for several clinical covariates. Usage of these medications decreased in the 48 hours following delirium identification, except for atypical antipsychotics, whose use increased. Other medication classes such as steroids, benzodiazepines, and sleep aids were not initially associated with subsequent delirium, but prescription patterns still changed after delirium identification. Conclusions Early exposure to multiple medication classes is associated with the subsequent development of delirium in patients with stroke. Additionally, prescription patterns changed following delirium identification, suggesting that some of the associated medication classes may represent modifiable targets for future delirium prevention strategies, although future study is needed." @default.
• W4385506105 created "2023-08-03" @default.
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• W4385506105 date "2023-09-01" @default.
• W4385506105 modified "2023-10-17" @default.
• W4385506105 title "Associations between early in-hospital medications and the development of delirium in patients with stroke" @default.
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• W4385506105 cites W1990128620 @default.
• W4385506105 cites W1991944563 @default.
• W4385506105 cites W1998849875 @default.
• W4385506105 cites W2000541529 @default.
• W4385506105 cites W2003802296 @default.
• W4385506105 cites W2004284087 @default.
• W4385506105 cites W2005774617 @default.
• W4385506105 cites W2017982517 @default.
• W4385506105 cites W2038799193 @default.
• W4385506105 cites W2054290601 @default.
• W4385506105 cites W2064590051 @default.
• W4385506105 cites W2068028498 @default.
• W4385506105 cites W2068335404 @default.
• W4385506105 cites W2077911405 @default.
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• W4385506105 cites W2088577369 @default.
• W4385506105 cites W2114943413 @default.
• W4385506105 cites W2118452576 @default.
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• W4385506105 cites W2136600569 @default.
• W4385506105 cites W2138928595 @default.
• W4385506105 cites W2141710162 @default.
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• W4385506105 cites W2163565743 @default.
• W4385506105 cites W2172036914 @default.
• W4385506105 cites W2193242030 @default.
• W4385506105 cites W2283304113 @default.
• W4385506105 cites W2429897320 @default.
• W4385506105 cites W2519898594 @default.
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• W4385506105 doi "https://doi.org/10.1016/j.jstrokecerebrovasdis.2023.107249" @default.
• W4385506105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37536017" @default.
• W4385506105 hasPublicationYear "2023" @default.
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