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• W4385506229 abstract "Cancer cells exhibit metabolic reprogramming and bioenergetic alteration, utilizing glucose fermentation for energy production, known as the Warburg effect. However, there are a lack of comprehensive reviews summarizing the metabolic reprogramming, bioenergetic alteration, and their oncogenetic links in gastrointestinal (GI) cancers. Furthermore, the efficacy and treatment potential of emerging anticancer drugs targeting these alterations in GI cancers require further evaluation. This review highlights the interplay between aerobic glycolysis, the tricarboxylic acid (TCA) cycle, and oxidative phosphorylation (OXPHOS) in cancer cells, as well as hypotheses on the molecular mechanisms that trigger this alteration. The role of hypoxia-inducible transcription factors, tumor suppressors, and the oncogenetic link between hypoxia-related enzymes, bioenergetic changes, and GI cancer are also discussed. This review emphasizes the potential of targeting bioenergetic regulators for anti-cancer therapy, particularly for GI cancers. Emphasizing the potential of targeting bioenergetic regulators for GI cancer therapy, the review categorizes these regulators into aerobic glycolysis/ lactate biosynthesis/transportation and TCA cycle/coupled OXPHOS. We also detail various anti-cancer drugs and strategies that have produced pre-clinical and/or clinical evidence in treating GI cancers, as well as the challenges posed by these drugs. Here we highlight that understanding dysregulated cancer cell bioenergetics is critical for effective treatments, although the diverse metabolic patterns present challenges for targeted therapies. Further research is needed to comprehend the specific mechanisms of inhibiting bioenergetic enzymes, address side effects, and leverage high-throughput multi-omics and spatial omics to gain insights into cancer cell heterogeneity for targeted bioenergetic therapies." @default.
• W4385506229 created "2023-08-03" @default.
• W4385506229 creator A5001753991 @default.
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• W4385506229 creator A5049587579 @default.
• W4385506229 creator A5067174207 @default.
• W4385506229 creator A5081407148 @default.
• W4385506229 date "2023-08-07" @default.
• W4385506229 modified "2023-10-18" @default.
• W4385506229 title "Bioenergetic alteration in gastrointestinal cancers: The good, the bad and the ugly" @default.
• W4385506229 cites W1488760471 @default.
• W4385506229 cites W1503667331 @default.
• W4385506229 cites W1515192237 @default.
• W4385506229 cites W1528834211 @default.
• W4385506229 cites W1541739901 @default.
• W4385506229 cites W1546824456 @default.
• W4385506229 cites W1551396388 @default.
• W4385506229 cites W1553978925 @default.
• W4385506229 cites W1568188518 @default.
• W4385506229 cites W1576403695 @default.
• W4385506229 cites W169440811 @default.
• W4385506229 cites W171916445 @default.
• W4385506229 cites W1721827275 @default.
• W4385506229 cites W1749022239 @default.
• W4385506229 cites W1831965066 @default.
• W4385506229 cites W1894067934 @default.
• W4385506229 cites W1894201636 @default.
• W4385506229 cites W1932780354 @default.
• W4385506229 cites W1945992367 @default.
• W4385506229 cites W1959428162 @default.
• W4385506229 cites W1966099909 @default.
• W4385506229 cites W1966107102 @default.
• W4385506229 cites W1966660381 @default.
• W4385506229 cites W1967291345 @default.
• W4385506229 cites W1967340602 @default.
• W4385506229 cites W1968301922 @default.
• W4385506229 cites W1973174899 @default.
• W4385506229 cites W1973849569 @default.
• W4385506229 cites W1974744928 @default.
• W4385506229 cites W1982898855 @default.
• W4385506229 cites W1984054872 @default.
• W4385506229 cites W1984791437 @default.
• W4385506229 cites W1985750228 @default.
• W4385506229 cites W1986154783 @default.
• W4385506229 cites W1987862188 @default.
• W4385506229 cites W1989778011 @default.
• W4385506229 cites W1994071191 @default.
• W4385506229 cites W1996365670 @default.
• W4385506229 cites W1996611359 @default.
• W4385506229 cites W1997722072 @default.
• W4385506229 cites W2000528840 @default.
• W4385506229 cites W2001144536 @default.
• W4385506229 cites W2003842905 @default.
• W4385506229 cites W2010231324 @default.
• W4385506229 cites W2010394923 @default.
• W4385506229 cites W2011821957 @default.
• W4385506229 cites W2012439721 @default.
• W4385506229 cites W2013479777 @default.
• W4385506229 cites W2014793391 @default.
• W4385506229 cites W2015088299 @default.
• W4385506229 cites W2016680661 @default.
• W4385506229 cites W2017575850 @default.
• W4385506229 cites W2018559612 @default.
• W4385506229 cites W2018971639 @default.
• W4385506229 cites W2020790836 @default.
• W4385506229 cites W2023300506 @default.
• W4385506229 cites W2025424557 @default.
• W4385506229 cites W2025719835 @default.
• W4385506229 cites W2027786827 @default.
• W4385506229 cites W2028974980 @default.
• W4385506229 cites W2030403598 @default.
• W4385506229 cites W2033254113 @default.
• W4385506229 cites W2033958147 @default.
• W4385506229 cites W2036065781 @default.
• W4385506229 cites W2036113953 @default.
• W4385506229 cites W2036315926 @default.
• W4385506229 cites W2037679360 @default.
• W4385506229 cites W2038009564 @default.
• W4385506229 cites W2039251470 @default.
• W4385506229 cites W2041771456 @default.
• W4385506229 cites W2044827397 @default.
• W4385506229 cites W2045417725 @default.
• W4385506229 cites W2045717811 @default.
• W4385506229 cites W2047050043 @default.
• W4385506229 cites W2048390688 @default.
• W4385506229 cites W2050244937 @default.
• W4385506229 cites W2051181260 @default.
• W4385506229 cites W2054528072 @default.
• W4385506229 cites W2056420027 @default.
• W4385506229 cites W2056863443 @default.
• W4385506229 cites W2062207706 @default.
• W4385506229 cites W2063229165 @default.
• W4385506229 cites W2064162418 @default.
• W4385506229 cites W2067145600 @default.
• W4385506229 cites W2072451938 @default.
• W4385506229 cites W2076112957 @default.
• W4385506229 cites W2077175808 @default.
• W4385506229 cites W2078693224 @default.

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