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- W4385513892 abstract "Abstract Background The hypothetical concept of ‘macrocyclic cavity’ is largely employed as useful model to interpret the affinity of metal ions for the macrocyclic chelating ligand 2,2′,2′′,2′′′-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (H 4 DOTA). It Is hypothesized that a close matching between the size of the macrocyclic cavity and that of the metallic ion is a key parameter to ensure the high-yield formation of stable coordination metal-DOTA complex. This approach has become popular in the design of radiopharmaceuticals containing radiometals and H 4 DOTA as chelating group. Results Based on X-ray structural data of metallic complexes formed by the ligand H 4 DOTA upon coordination with a variety of metals, an elementary argument based on Euclidean geometry is presented here that questions the existence of the hypothetical ‘macrocyclic cavity’ within the chelator macrocycle. The geometrical analysis was applied to the complex formed by a Ga 3+ ion coordinated to H 4 DOTA as model compound. Conclusions Application of Euclidean geometry to calculate bond angles in the coordination complex of the ligand H 4 DOTA with the Ga +3 ion, supposed to incorporate a hypothetical ‘macrocyclic cavity’, revealed that this conceptual entity has no physical reality and, therefore, cannot be considered a meaningful description of a stable structural arrangement for metallic radiopharmaceuticals." @default.
- W4385513892 created "2023-08-04" @default.
- W4385513892 creator A5070643532 @default.
- W4385513892 date "2023-08-03" @default.
- W4385513892 modified "2023-09-25" @default.
- W4385513892 title "The DOTA macrocyclic cavity in metallic radiopharmaceuticals: Mythology or reality?" @default.
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- W4385513892 doi "https://doi.org/10.1186/s41181-023-00202-6" @default.
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