FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385513992> ?p ?o ?g. }

• W4385513992 endingPage "581" @default.
• W4385513992 startingPage "575" @default.
• W4385513992 abstract "To investigate the expression and significance of insulinoma associated protein 1 (INSM1) and SRY-related high-mobility group box 11 (SOX11) in pancreatic neuroendocrine tumor (PNET) and solid pseudopapillary neoplasm (SPN).To detect the expression of INSM1, SOX11, Syn, CgA, CD56, β-catenin, and CD99 in 56 cases of PNET, 42 cases of SPN, 16 cases of ductal adenocarcinoma (DACC) and 8 cases of acinar cell carcinoma (ACC) by immunohistochemistry. The application value of combination of INSM1 and SOX11 was compared with conventional markers (Syn, CgA, CD56, β-catenin, and CD99) in diagnosis and differential diagnosis of PNET and SPN.(1) In the 56 cases of PNET, the positive signals of INSM1 were located in the tumor and islet nucleus, the positive expression rate in the tumor tissues was 91.07% (51/56), whereas the signal was absent in 42 cases of SPN, 16 cases of DACC and 8 cases of ACC, and there were significant statistical difference between PNET with SPN, DACC, and ACC respectively (P < 0.001). (2) The positive signals of SOX11 were located in the tumor nucleus, with the positive expression rate was 92.86% (39/42) in SPN, however, the positive expression rate of SOX11 was 8.93% (5/56) in PNET, which included 3 cases of G1 and 2 cases of G3 types of PNET, the SOX11 positive signal was absent in 16 cases of DACC, 8 cases of ACC and peritumoral nomal pancreatic tissue, and the differences were statistically significant of positive rate between SPN with PNET, DACC and ACC, respectively (P < 0.001). (3) The sensitivity of INSM1(+)/SOX11(-) immunophenotype for PNET was 85.71%, vs. CD56 (57.14%), the difference was statistically significant (P=0.001); vs. Syn (80.36%) and CgA (71.43%), the difference was no statistically significant (P>0.05). The specificity of INSM1(+)/SOX11(-) for PNET was 100.00%, vs. Syn (42.86%) and CD56 (47.62%), the difference was statistically significant (P < 0.001); vs. CgA (92.86%), the difference was no statistically significant (P>0.05). The sensitivity of INSM1(-)/SOX11(+) immunophenotype for SPN was 92.86%, vs. β-catenin (90.48%) and CD99 (85.71%), the difference was no statistically significant (P>0.05). The specificity of INSM1(-)/SOX11(+) for SPN was 96.43%, vs. CD99 (48.21%), the difference was statistically significant (P < 0.001); vs. β-catenin (100.00%), the difference was no statistically significant (P>0.05). (4) The positive expression of INSM1 and SOX11 in PNET and SOX11 were not correlated with clinicopathological parameters (age, gender, tumor size, location, grade, and metastasis) (P>0.05).The positive expression patterns of INSM1 and SOX11 in PNET and SPN respectively are conductive to distinguish the both tumors. The combination of both take precedence over some corresponding conventional immunohistochemical markers in terms of sensitivity and specificity." @default.
• W4385513992 created "2023-08-04" @default.
• W4385513992 creator A5010288528 @default.
• W4385513992 creator A5021863506 @default.
• W4385513992 creator A5029786366 @default.
• W4385513992 creator A5044428047 @default.
• W4385513992 creator A5048153613 @default.
• W4385513992 creator A5058597594 @default.
• W4385513992 creator A5064491433 @default.
• W4385513992 date "2023-08-18" @default.
• W4385513992 modified "2023-09-23" @default.
• W4385513992 title "[Expression and significance of INSM1 and SOX11 in pancreatic neuroendocrine tumor and solid pseudopapillary neoplasm]." @default.
• W4385513992 cites W1762727355 @default.
• W4385513992 cites W1980858003 @default.
• W4385513992 cites W2011243234 @default.
• W4385513992 cites W2167795739 @default.
• W4385513992 cites W2179485673 @default.
• W4385513992 cites W2289046895 @default.
• W4385513992 cites W2576607572 @default.
• W4385513992 cites W2746755082 @default.
• W4385513992 cites W2766281101 @default.
• W4385513992 cites W2778362274 @default.
• W4385513992 cites W2790401975 @default.
• W4385513992 cites W2894846397 @default.
• W4385513992 cites W2898130799 @default.
• W4385513992 cites W2997704705 @default.
• W4385513992 cites W3001997869 @default.
• W4385513992 cites W3009187843 @default.
• W4385513992 cites W3010114939 @default.
• W4385513992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534634" @default.
• W4385513992 hasPublicationYear "2023" @default.
• W4385513992 type Work @default.
• W4385513992 citedByCount "0" @default.
• W4385513992 crossrefType "journal-article" @default.
• W4385513992 hasAuthorship W4385513992A5010288528 @default.
• W4385513992 hasAuthorship W4385513992A5021863506 @default.
• W4385513992 hasAuthorship W4385513992A5029786366 @default.
• W4385513992 hasAuthorship W4385513992A5044428047 @default.
• W4385513992 hasAuthorship W4385513992A5048153613 @default.
• W4385513992 hasAuthorship W4385513992A5058597594 @default.
• W4385513992 hasAuthorship W4385513992A5064491433 @default.
• W4385513992 hasConcept C121608353 @default.
• W4385513992 hasConcept C126226738 @default.
• W4385513992 hasConcept C126322002 @default.
• W4385513992 hasConcept C142724271 @default.
• W4385513992 hasConcept C147447768 @default.
• W4385513992 hasConcept C204232928 @default.
• W4385513992 hasConcept C2778764654 @default.
• W4385513992 hasConcept C2780053029 @default.
• W4385513992 hasConcept C2780635560 @default.
• W4385513992 hasConcept C2781182431 @default.
• W4385513992 hasConcept C71924100 @default.
• W4385513992 hasConcept C86803240 @default.
• W4385513992 hasConceptScore W4385513992C121608353 @default.
• W4385513992 hasConceptScore W4385513992C126226738 @default.
• W4385513992 hasConceptScore W4385513992C126322002 @default.
• W4385513992 hasConceptScore W4385513992C142724271 @default.
• W4385513992 hasConceptScore W4385513992C147447768 @default.
• W4385513992 hasConceptScore W4385513992C204232928 @default.
• W4385513992 hasConceptScore W4385513992C2778764654 @default.
• W4385513992 hasConceptScore W4385513992C2780053029 @default.
• W4385513992 hasConceptScore W4385513992C2780635560 @default.
• W4385513992 hasConceptScore W4385513992C2781182431 @default.
• W4385513992 hasConceptScore W4385513992C71924100 @default.
• W4385513992 hasConceptScore W4385513992C86803240 @default.
• W4385513992 hasIssue "4" @default.
• W4385513992 hasLocation W43855139921 @default.
• W4385513992 hasOpenAccess W4385513992 @default.
• W4385513992 hasPrimaryLocation W43855139921 @default.
• W4385513992 hasRelatedWork W1498202335 @default.
• W4385513992 hasRelatedWork W1931843710 @default.
• W4385513992 hasRelatedWork W1963873052 @default.
• W4385513992 hasRelatedWork W2013507592 @default.
• W4385513992 hasRelatedWork W2021173905 @default.
• W4385513992 hasRelatedWork W2300292333 @default.
• W4385513992 hasRelatedWork W2364973444 @default.
• W4385513992 hasRelatedWork W2367350837 @default.
• W4385513992 hasRelatedWork W2405692590 @default.
• W4385513992 hasRelatedWork W4318218013 @default.
• W4385513992 hasVolume "55" @default.
• W4385513992 isParatext "false" @default.
• W4385513992 isRetracted "false" @default.
• W4385513992 workType "article" @default.