Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514003> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4385514003 endingPage "11878" @default.
- W4385514003 startingPage "11874" @default.
- W4385514003 abstract "The combined use of fluorescence-activated cell sorting (FACS) and single-cell inductively coupled plasma mass spectrometry (SC-ICP-MS) is reported, for the first time, in this work. It is applied to evaluate the differences between the cellular uptake of ultrasmall iron oxide nanoparticles (FeNPs) loaded with cisplatin(IV) prodrug (FeNPs-Pt(IV)) and cisplatin regarding cell viability. For this aim, FACS is applied to separate viable, apoptotic, and necrotic A2780 ovarian cancer cells after exposing them to the nanotransported prodrug and cisplatin, respectively. The different sorted cell populations are individually analyzed using quantitative SC-ICP-MS to address the intracellular amount of Pt. The highest Pt intracellular content occurs in the apoptotic cell population (about 2.1 fg Pt/cell) with a narrow intercellular distribution when using FeNPs-Pt(IV) nanoprodrug and containing the largest number of cells (75% of the total). In the case of the cisplatin-treated cells, the highest Pt content (about 1.6 fg Pt/cell) could be determined in the viable sorted cell population. The combined methodology, never explored before, permits a more accurate picture of the effect of the intracellular drug content together with the cell death mechanisms associated with the free drug and the nanotransported prodrug, respectively, and opens the door to many possible single-cell experiments in sorted cell populations." @default.
- W4385514003 created "2023-08-04" @default.
- W4385514003 creator A5018570875 @default.
- W4385514003 creator A5050942748 @default.
- W4385514003 creator A5079103262 @default.
- W4385514003 date "2023-08-03" @default.
- W4385514003 modified "2023-10-18" @default.
- W4385514003 title "Single-Cell ICP-MS in Combination with Fluorescence-Activated Cell Sorting for Investigating the Effects of Nanotransported Cisplatin(IV) Prodrugs" @default.
- W4385514003 cites W2015030879 @default.
- W4385514003 cites W2023453068 @default.
- W4385514003 cites W2095122846 @default.
- W4385514003 cites W2102649152 @default.
- W4385514003 cites W2106658907 @default.
- W4385514003 cites W2339851538 @default.
- W4385514003 cites W2548239247 @default.
- W4385514003 cites W2606698872 @default.
- W4385514003 cites W2761135422 @default.
- W4385514003 cites W2810100357 @default.
- W4385514003 cites W2945890079 @default.
- W4385514003 cites W2946531342 @default.
- W4385514003 cites W3010557696 @default.
- W4385514003 cites W3028994561 @default.
- W4385514003 cites W3087337553 @default.
- W4385514003 cites W3138411791 @default.
- W4385514003 cites W3205883523 @default.
- W4385514003 doi "https://doi.org/10.1021/acs.analchem.3c02506" @default.
- W4385514003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37535006" @default.
- W4385514003 hasPublicationYear "2023" @default.
- W4385514003 type Work @default.
- W4385514003 citedByCount "1" @default.
- W4385514003 countsByYear W43855140032023 @default.
- W4385514003 crossrefType "journal-article" @default.
- W4385514003 hasAuthorship W4385514003A5018570875 @default.
- W4385514003 hasAuthorship W4385514003A5050942748 @default.
- W4385514003 hasAuthorship W4385514003A5079103262 @default.
- W4385514003 hasConcept C108215921 @default.
- W4385514003 hasConcept C144024400 @default.
- W4385514003 hasConcept C1491633281 @default.
- W4385514003 hasConcept C149923435 @default.
- W4385514003 hasConcept C153911025 @default.
- W4385514003 hasConcept C185592680 @default.
- W4385514003 hasConcept C190283241 @default.
- W4385514003 hasConcept C2776694085 @default.
- W4385514003 hasConcept C2778239845 @default.
- W4385514003 hasConcept C2778630268 @default.
- W4385514003 hasConcept C2908647359 @default.
- W4385514003 hasConcept C53227056 @default.
- W4385514003 hasConcept C54355233 @default.
- W4385514003 hasConcept C553184892 @default.
- W4385514003 hasConcept C55493867 @default.
- W4385514003 hasConcept C79879829 @default.
- W4385514003 hasConcept C86803240 @default.
- W4385514003 hasConceptScore W4385514003C108215921 @default.
- W4385514003 hasConceptScore W4385514003C144024400 @default.
- W4385514003 hasConceptScore W4385514003C1491633281 @default.
- W4385514003 hasConceptScore W4385514003C149923435 @default.
- W4385514003 hasConceptScore W4385514003C153911025 @default.
- W4385514003 hasConceptScore W4385514003C185592680 @default.
- W4385514003 hasConceptScore W4385514003C190283241 @default.
- W4385514003 hasConceptScore W4385514003C2776694085 @default.
- W4385514003 hasConceptScore W4385514003C2778239845 @default.
- W4385514003 hasConceptScore W4385514003C2778630268 @default.
- W4385514003 hasConceptScore W4385514003C2908647359 @default.
- W4385514003 hasConceptScore W4385514003C53227056 @default.
- W4385514003 hasConceptScore W4385514003C54355233 @default.
- W4385514003 hasConceptScore W4385514003C553184892 @default.
- W4385514003 hasConceptScore W4385514003C55493867 @default.
- W4385514003 hasConceptScore W4385514003C79879829 @default.
- W4385514003 hasConceptScore W4385514003C86803240 @default.
- W4385514003 hasFunder F4320322930 @default.
- W4385514003 hasFunder F4320325113 @default.
- W4385514003 hasFunder F4320332101 @default.
- W4385514003 hasIssue "32" @default.
- W4385514003 hasLocation W43855140031 @default.
- W4385514003 hasLocation W43855140032 @default.
- W4385514003 hasOpenAccess W4385514003 @default.
- W4385514003 hasPrimaryLocation W43855140031 @default.
- W4385514003 hasRelatedWork W2023053165 @default.
- W4385514003 hasRelatedWork W2125692928 @default.
- W4385514003 hasRelatedWork W2144448045 @default.
- W4385514003 hasRelatedWork W2371090843 @default.
- W4385514003 hasRelatedWork W2371307295 @default.
- W4385514003 hasRelatedWork W2379624126 @default.
- W4385514003 hasRelatedWork W2386361724 @default.
- W4385514003 hasRelatedWork W2391804837 @default.
- W4385514003 hasRelatedWork W3028727730 @default.
- W4385514003 hasRelatedWork W3044344817 @default.
- W4385514003 hasVolume "95" @default.
- W4385514003 isParatext "false" @default.
- W4385514003 isRetracted "false" @default.
- W4385514003 workType "article" @default.