Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514097> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4385514097 abstract "Background: Acute necrotizing pancreatitis is a serious pancreatic injury with limited effective treatments. This study aims to investigate the therapeutic effects of hesperidin on L-arginine-induced acute pancreatitis and its potential targets. Methods: The authors induced acute pancreatitis in mice by administering two hourly intraperitoneal injections of L-arginine-HCl, and evaluated the impact of hesperidin on pancreatic and lung tissues, plasma amylase activity, and myeloperoxidase content. Additionally, necrosis and mitochondrial function was tested in primary pancreatic acinar cells. The interactions between hesperidin and proteins involved in necrosis and mitochondrial dysfunction were further invested using in silico molecular docking and molecular dynamic simulations. Results: Hesperidin effectively ameliorated the severity of acute necrotizing pancreatitis by reducing plasma amylase, pancreatic MPO, serum IL-6 levels, pancreatic edema, inflammation, and pancreatic necrosis. Hesperidin also protected against acute pancreatitis-associated lung injury and prevented acinar cell necrosis, mitochondrial membrane potential loss, and ATP depletion. In addition, hesperidin exhibited a high binding affinity with SIRT1 and increased the protein levels of SIRT1. The SIRT1 inhibitor EX527 abolished the protective effect of hesperidin against necrosis in acinar cells. Conclusion: These findings indicate that hesperidin alleviates the severity of acute necrotizing pancreatitis by activating SIRT1, which may provide insight into the mechanisms of natural compounds in treating AP. Hesperidin has potential as a therapeutic agent for acute necrotizing pancreatitis and provides a new approach for novel therapeutic strategies." @default.
- W4385514097 created "2023-08-04" @default.
- W4385514097 creator A5000320455 @default.
- W4385514097 creator A5005353047 @default.
- W4385514097 creator A5013511858 @default.
- W4385514097 creator A5015069162 @default.
- W4385514097 creator A5023363049 @default.
- W4385514097 creator A5065037360 @default.
- W4385514097 creator A5067142463 @default.
- W4385514097 creator A5074103305 @default.
- W4385514097 date "2023-08-03" @default.
- W4385514097 modified "2023-09-27" @default.
- W4385514097 title "Hesperidin Alleviates Acute Necrotizing Pancreatitis by Activating SIRT1 ‒ Molecular Docking, Molecular Dynamics Simulation, and Experimental Validation" @default.
- W4385514097 doi "https://doi.org/10.2174/1386207326666230803140408" @default.
- W4385514097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534793" @default.
- W4385514097 hasPublicationYear "2023" @default.
- W4385514097 type Work @default.
- W4385514097 citedByCount "0" @default.
- W4385514097 crossrefType "journal-article" @default.
- W4385514097 hasAuthorship W4385514097A5000320455 @default.
- W4385514097 hasAuthorship W4385514097A5005353047 @default.
- W4385514097 hasAuthorship W4385514097A5013511858 @default.
- W4385514097 hasAuthorship W4385514097A5015069162 @default.
- W4385514097 hasAuthorship W4385514097A5023363049 @default.
- W4385514097 hasAuthorship W4385514097A5065037360 @default.
- W4385514097 hasAuthorship W4385514097A5067142463 @default.
- W4385514097 hasAuthorship W4385514097A5074103305 @default.
- W4385514097 hasConcept C126322002 @default.
- W4385514097 hasConcept C142724271 @default.
- W4385514097 hasConcept C185592680 @default.
- W4385514097 hasConcept C203565725 @default.
- W4385514097 hasConcept C204787440 @default.
- W4385514097 hasConcept C2775967933 @default.
- W4385514097 hasConcept C2776128092 @default.
- W4385514097 hasConcept C2776670229 @default.
- W4385514097 hasConcept C2776914184 @default.
- W4385514097 hasConcept C2991930265 @default.
- W4385514097 hasConcept C503630168 @default.
- W4385514097 hasConcept C71924100 @default.
- W4385514097 hasConcept C98274493 @default.
- W4385514097 hasConceptScore W4385514097C126322002 @default.
- W4385514097 hasConceptScore W4385514097C142724271 @default.
- W4385514097 hasConceptScore W4385514097C185592680 @default.
- W4385514097 hasConceptScore W4385514097C203565725 @default.
- W4385514097 hasConceptScore W4385514097C204787440 @default.
- W4385514097 hasConceptScore W4385514097C2775967933 @default.
- W4385514097 hasConceptScore W4385514097C2776128092 @default.
- W4385514097 hasConceptScore W4385514097C2776670229 @default.
- W4385514097 hasConceptScore W4385514097C2776914184 @default.
- W4385514097 hasConceptScore W4385514097C2991930265 @default.
- W4385514097 hasConceptScore W4385514097C503630168 @default.
- W4385514097 hasConceptScore W4385514097C71924100 @default.
- W4385514097 hasConceptScore W4385514097C98274493 @default.
- W4385514097 hasLocation W43855140971 @default.
- W4385514097 hasLocation W43855140972 @default.
- W4385514097 hasOpenAccess W4385514097 @default.
- W4385514097 hasPrimaryLocation W43855140971 @default.
- W4385514097 hasRelatedWork W2068359807 @default.
- W4385514097 hasRelatedWork W2096230184 @default.
- W4385514097 hasRelatedWork W2134287168 @default.
- W4385514097 hasRelatedWork W2345101555 @default.
- W4385514097 hasRelatedWork W2360015576 @default.
- W4385514097 hasRelatedWork W2375435727 @default.
- W4385514097 hasRelatedWork W2413063882 @default.
- W4385514097 hasRelatedWork W2948931474 @default.
- W4385514097 hasRelatedWork W2977959280 @default.
- W4385514097 hasRelatedWork W2981255723 @default.
- W4385514097 hasVolume "26" @default.
- W4385514097 isParatext "false" @default.
- W4385514097 isRetracted "false" @default.
- W4385514097 workType "article" @default.