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- W4385514196 abstract "Abstract Background and Objectives Blood donor variability can affect the storage properties of packed red blood cells (PRBCs). This study aimed to determine the association of donor characteristics with in vitro storage haemolysis of PRBCs. Materials and Methods In the prospective observational study, a total of 109 whole blood donors were enrolled using the purposive sampling method. A pre‐donation sample was collected for haemoglobin (Hb) and serum uric acid (UA) levels. PRBC aliquots were tested for potassium, lactate dehydrogenase (LDH), Hb, haematocrit, plasma Hb and haemolysis on days 1, 21 and 35 of storage. The association of these parameters with donor age, sex, donation status, dietary pattern and body mass index was determined. Results Mean haemolysis was significantly higher in PRBCs from donors with UA levels ≤6 mg/dL than donors with UA levels >6 mg/dL on day 35 of storage (0.22 ± 0.11 vs. 0.18 ± 0.07, p = 0.03). Median plasma Hb (mg/L) was significantly higher in PRBCs from first‐time donors on day 21 (586 vs. 509, p = 0.05) and day 35 (1507 vs. 1358, p = 0.02) of storage in comparison to frequent donors. Significantly higher mean potassium ( p = 0.04 day 1; p = 0.02 day 21) and median LDH values ( p = 0.02 day 1, p = 0.05 day 21) were observed in PRBCs from male donors. A statistically significant positive association was observed between donor UA and LDH levels of PRBCs on day 35 of storage ( β coefficient: 715.52, p ‐value: 0.003) on multiple regression analysis. Conclusion In vitro haemolysis of PRBCs is affected by blood donor characteristics." @default.
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- W4385514196 date "2023-08-02" @default.
- W4385514196 modified "2023-10-16" @default.
- W4385514196 title "Association of blood donor characteristics and in vitro haemolysis of packed red blood cell concentrates during storage" @default.
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- W4385514196 doi "https://doi.org/10.1111/vox.13507" @default.
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