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• W4385514302 abstract "Abstract Neuropsychiatric symptoms are intrinsic to Progressive Supranuclear Palsy (PSP) and a spoonful of studies investigated their imaging correlates. Describe (I) the frequency and severity of neuropsychiatric symptoms in PSP and (II) their structural imaging correlates. Twenty-six PSP patients underwent Neuropsychiatric Inventory (NPI) and brain 3D T1-weighted MRI. Spearman’s rho with Bonferroni correction was used to investigate correlations between NPI scores and volumes of gray matter regions. More than 80% of patients presented at least one behavioral symptom of any severity. The most frequent and severe were depression/dysphoria, apathy, and irritability/lability. Significant relationships were found between the severity of irritability and right pars opercularis volume (p < 0.001) as well as between the frequency of agitation/aggression and left lateral occipital volume (p < 0.001). Depression, apathy, and irritability are the most common neuropsychiatric symptoms in PSP. Moreover, we found a relationship between specific positive symptoms as irritability and agitation/aggression and greater volume of the right pars opercularis cortex and lower volume of the left occipital cortex, respectively, which deserve further investigations." @default.
• W4385514302 created "2023-08-04" @default.
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• W4385514302 date "2023-08-03" @default.
• W4385514302 modified "2023-10-14" @default.
• W4385514302 title "Frequency and imaging correlates of neuropsychiatric symptoms in Progressive Supranuclear Palsy" @default.
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• W4385514302 doi "https://doi.org/10.1007/s00702-023-02676-9" @default.
• W4385514302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37535119" @default.
• W4385514302 hasPublicationYear "2023" @default.
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