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- W4385514387 abstract "Abstract Pulsatile spinal cord and CSF velocities related to the cardiac cycle can be depicted by phase‐contrast MRI. Among patients with spontaneous intracranial hypotension, we have recently described relevant differences compared with healthy controls in segment C2/C3. The method might be a promising tool to solve clinical and diagnostic ambiguities. Therefore, it is important to understand the physiological range and the effects of clinical and anatomical parameters in healthy volunteers. Within a prospective study, 3D T 2 ‐weighted MRI for spinal canal anatomy and cardiac‐gated phase‐contrast MRI adapted to CSF flow and spinal cord motion for time‐resolved velocity data and derivatives were performed in 70 participants (age 20–79 years) in segments C2/C3 and C5/C6. Correlations were analyzed by multiple linear regression models; p < 0.01 was required to assume a significant impact of clinical or anatomical data quantified by the regression coefficient B . Data showed that in C2/C3, the CSF and spinal cord craniocaudal velocity ranges were 4.5 ± 0.9 and 0.55 ± 0.15 cm/s; the total displacements were 1.1 ± 0.3 and 0.07 ± 0.02 cm, respectively. The craniocaudal range of the CSF flow rate was 8.6 ± 2.4 mL/s; the CSF stroke volume was 2.1 ± 0.7 mL. In C5/C5, physiological narrowing of the spinal canal caused higher CSF velocity ranges and lower stroke volume (C5/C6 B = +1.64 cm/s, p < 0.001; B = −0.4 mL, p = 0.002, respectively). Aging correlated to lower spinal cord motion (e.g., B = −0.01 cm per 10 years of aging, p < 0.001). Increased diastolic blood pressure was associated with lower spinal cord motion and CSF flow parameters (e.g., C2/C3 CSF stroke volume B = −0.3 mL per 10 mmHg, p < 0.001). Males showed higher CSF flow and spinal cord motion (e.g., CSF stroke volume B = +0.5 mL, p < 0.001; total displacement spinal cord B = +0.016 cm, p = 0.002). We therefore propose to stratify data for age and sex and to adjust for diastolic blood pressure and segmental narrowing in future clinical studies." @default.
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- W4385514387 date "2023-08-03" @default.
- W4385514387 modified "2023-10-17" @default.
- W4385514387 title "Spinal cord motion and CSF flow in the cervical spine of 70 healthy participants" @default.
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- W4385514387 doi "https://doi.org/10.1002/nbm.5013" @default.
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