Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514404> ?p ?o ?g. }
- W4385514404 endingPage "1365" @default.
- W4385514404 startingPage "1349" @default.
- W4385514404 abstract "Matrix metalloproteinases (MMPs) are a class of endopeptidases that are dependent on zinc and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal parts in human physiology and pathology. MMPs regulate normal tissue and cellular functions, including tissue development, remodeling, angiogenesis, bone formation, and wound healing. Several diseases, including cancer, inflammation, cardiovascular diseases, and nervous system disorders, have been linked to dysregulated expression of specific MMP subtypes, which can promote tumor progression, metastasis, and inflammation. Various MMP-responsive drug delivery and release systems have been developed by harnessing cleavage activities and overexpression of MMPs in affected regions. Herein, we review the structure, substrates, and physiological and pathological functions of various MMPs and highlight the strategies for designing MMP-responsive nanoparticles to improve the targeting efficiency, penetration, and protection of therapeutic payloads." @default.
- W4385514404 created "2023-08-04" @default.
- W4385514404 creator A5018224082 @default.
- W4385514404 creator A5081715937 @default.
- W4385514404 creator A5088958812 @default.
- W4385514404 date "2023-08-03" @default.
- W4385514404 modified "2023-10-15" @default.
- W4385514404 title "Matrix Metalloproteinase-Responsive Drug Delivery Systems" @default.
- W4385514404 cites W1484677286 @default.
- W4385514404 cites W1898684747 @default.
- W4385514404 cites W1968754817 @default.
- W4385514404 cites W1973994764 @default.
- W4385514404 cites W1981454857 @default.
- W4385514404 cites W1982808845 @default.
- W4385514404 cites W1991948483 @default.
- W4385514404 cites W2002771508 @default.
- W4385514404 cites W2009265227 @default.
- W4385514404 cites W2018349757 @default.
- W4385514404 cites W2028431762 @default.
- W4385514404 cites W2030031481 @default.
- W4385514404 cites W2032573169 @default.
- W4385514404 cites W2034976648 @default.
- W4385514404 cites W2036489895 @default.
- W4385514404 cites W2036743679 @default.
- W4385514404 cites W2038449477 @default.
- W4385514404 cites W2038732333 @default.
- W4385514404 cites W2046314109 @default.
- W4385514404 cites W2051018596 @default.
- W4385514404 cites W2053043355 @default.
- W4385514404 cites W2065362813 @default.
- W4385514404 cites W2071359561 @default.
- W4385514404 cites W2077466603 @default.
- W4385514404 cites W2088035942 @default.
- W4385514404 cites W2099132605 @default.
- W4385514404 cites W2103420764 @default.
- W4385514404 cites W2103868159 @default.
- W4385514404 cites W2107874449 @default.
- W4385514404 cites W2107910518 @default.
- W4385514404 cites W2117272739 @default.
- W4385514404 cites W2117481374 @default.
- W4385514404 cites W2126634468 @default.
- W4385514404 cites W2128794104 @default.
- W4385514404 cites W2141518860 @default.
- W4385514404 cites W2154401382 @default.
- W4385514404 cites W2163185647 @default.
- W4385514404 cites W2164840927 @default.
- W4385514404 cites W2171006416 @default.
- W4385514404 cites W2274044837 @default.
- W4385514404 cites W2333625442 @default.
- W4385514404 cites W2343045213 @default.
- W4385514404 cites W2510654794 @default.
- W4385514404 cites W2511364181 @default.
- W4385514404 cites W2513721137 @default.
- W4385514404 cites W2516069926 @default.
- W4385514404 cites W2592761639 @default.
- W4385514404 cites W2599889833 @default.
- W4385514404 cites W2615493985 @default.
- W4385514404 cites W2625838116 @default.
- W4385514404 cites W2755010202 @default.
- W4385514404 cites W2802537944 @default.
- W4385514404 cites W2883398259 @default.
- W4385514404 cites W2886660879 @default.
- W4385514404 cites W2901651053 @default.
- W4385514404 cites W2908606663 @default.
- W4385514404 cites W2914324402 @default.
- W4385514404 cites W2922135147 @default.
- W4385514404 cites W2943724291 @default.
- W4385514404 cites W2953342712 @default.
- W4385514404 cites W2954884521 @default.
- W4385514404 cites W2960975759 @default.
- W4385514404 cites W2972942678 @default.
- W4385514404 cites W3016061954 @default.
- W4385514404 cites W3019034047 @default.
- W4385514404 cites W3028827096 @default.
- W4385514404 cites W3038100422 @default.
- W4385514404 cites W3038981103 @default.
- W4385514404 cites W3080574698 @default.
- W4385514404 cites W3093718259 @default.
- W4385514404 cites W3125340482 @default.
- W4385514404 cites W3134788761 @default.
- W4385514404 cites W3165320406 @default.
- W4385514404 cites W3180194790 @default.
- W4385514404 cites W3197790492 @default.
- W4385514404 cites W3206724718 @default.
- W4385514404 cites W4210791608 @default.
- W4385514404 cites W4220873600 @default.
- W4385514404 cites W4224037358 @default.
- W4385514404 cites W4250908540 @default.
- W4385514404 cites W4292236348 @default.
- W4385514404 cites W4318204956 @default.
- W4385514404 cites W4321460227 @default.
- W4385514404 cites W4378470364 @default.
- W4385514404 doi "https://doi.org/10.1021/acs.bioconjchem.3c00266" @default.
- W4385514404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37533285" @default.
- W4385514404 hasPublicationYear "2023" @default.
- W4385514404 type Work @default.
- W4385514404 citedByCount "0" @default.
- W4385514404 crossrefType "journal-article" @default.