FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514405> ?p ?o ?g. }

• W4385514405 abstract "Abstract A series of pleuromutilin derivatives containing benzimidazole were designed, synthesized, and evaluated for their antibacterial activities against Methicillin‐resistant Staphylococcus aureus (MRSA) in this study. The in vitro antibacterial activities of the synthesized derivatives against four strains of S. aureus (MRSA ATCC 43300, S. aureus ATCC 29213, S. aureus 144, and S. aureus AD3) were determined by the broth dilution method. Among these derivatives, compound 58 exhibited superior in vitro antibacterial effect against MRSA (minimal inhibitory concentration [MIC] = 0.0625 μg/mL) than tiamulin (MIC = 0.5 μg/mL). Compound 58 possessed a faster bactericidal kinetic and a longer post‐antibiotic effect time against MRSA than tiamulin. Meanwhile, at 8 μg/mL concentration, compound 58 did not display obviously cytotoxic effect on the RAW 264.7 cells. In addition, compound 58 (−2.04 log 10 CFU/mL) displayed superior in vivo antibacterial efficacy than tiamulin (−1.02 log 10 CFU/mL) in reducing MRSA load in mice thigh infection model. In molecular docking study, compound 58 can successfully attach to the 50S ribosomal active site (the binding free energy is −8.11 kcal/mol). Therefore, compound 58 was a potential antibacterial candidate for combating MRSA infections." @default.
• W4385514405 created "2023-08-04" @default.
• W4385514405 creator A5015195367 @default.
• W4385514405 creator A5015575924 @default.
• W4385514405 creator A5016858210 @default.
• W4385514405 creator A5017206908 @default.
• W4385514405 creator A5029709682 @default.
• W4385514405 creator A5038736889 @default.
• W4385514405 creator A5056558563 @default.
• W4385514405 creator A5058660554 @default.
• W4385514405 creator A5062097440 @default.
• W4385514405 creator A5063399174 @default.
• W4385514405 date "2023-08-03" @default.
• W4385514405 modified "2023-09-27" @default.
• W4385514405 title "Design, synthesis, and biological evaluation of novel pleuromutilin derivatives containing benzimidazoles as effective anti‐MRSA agents" @default.
• W4385514405 cites W1975273750 @default.
• W4385514405 cites W2007985696 @default.
• W4385514405 cites W2028046413 @default.
• W4385514405 cites W2088074800 @default.
• W4385514405 cites W2134967712 @default.
• W4385514405 cites W2135783966 @default.
• W4385514405 cites W2141280048 @default.
• W4385514405 cites W2151150074 @default.
• W4385514405 cites W2169345021 @default.
• W4385514405 cites W2188038826 @default.
• W4385514405 cites W2312720395 @default.
• W4385514405 cites W2331347510 @default.
• W4385514405 cites W2338241584 @default.
• W4385514405 cites W2409814849 @default.
• W4385514405 cites W2411398791 @default.
• W4385514405 cites W2531025435 @default.
• W4385514405 cites W2554048294 @default.
• W4385514405 cites W2620635074 @default.
• W4385514405 cites W2785104789 @default.
• W4385514405 cites W2802325227 @default.
• W4385514405 cites W2952720799 @default.
• W4385514405 cites W2964556557 @default.
• W4385514405 cites W2966144538 @default.
• W4385514405 cites W2972673707 @default.
• W4385514405 cites W2981227515 @default.
• W4385514405 cites W2985836390 @default.
• W4385514405 cites W2990383099 @default.
• W4385514405 cites W3006203361 @default.
• W4385514405 cites W3024354797 @default.
• W4385514405 cites W3047255592 @default.
• W4385514405 cites W3085406212 @default.
• W4385514405 cites W3094261658 @default.
• W4385514405 cites W3190112138 @default.
• W4385514405 doi "https://doi.org/10.1002/ddr.22095" @default.
• W4385514405 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534779" @default.
• W4385514405 hasPublicationYear "2023" @default.
• W4385514405 type Work @default.
• W4385514405 citedByCount "0" @default.
• W4385514405 crossrefType "journal-article" @default.
• W4385514405 hasAuthorship W4385514405A5015195367 @default.
• W4385514405 hasAuthorship W4385514405A5015575924 @default.
• W4385514405 hasAuthorship W4385514405A5016858210 @default.
• W4385514405 hasAuthorship W4385514405A5017206908 @default.
• W4385514405 hasAuthorship W4385514405A5029709682 @default.
• W4385514405 hasAuthorship W4385514405A5038736889 @default.
• W4385514405 hasAuthorship W4385514405A5056558563 @default.
• W4385514405 hasAuthorship W4385514405A5058660554 @default.
• W4385514405 hasAuthorship W4385514405A5062097440 @default.
• W4385514405 hasAuthorship W4385514405A5063399174 @default.
• W4385514405 hasBestOaLocation W43855144051 @default.
• W4385514405 hasConcept C176947019 @default.
• W4385514405 hasConcept C178790620 @default.
• W4385514405 hasConcept C185592680 @default.
• W4385514405 hasConcept C202751555 @default.
• W4385514405 hasConcept C26381139 @default.
• W4385514405 hasConcept C2777052132 @default.
• W4385514405 hasConcept C2777241463 @default.
• W4385514405 hasConcept C2778484023 @default.
• W4385514405 hasConcept C2779489039 @default.
• W4385514405 hasConcept C2780104969 @default.
• W4385514405 hasConcept C3019249092 @default.
• W4385514405 hasConcept C501593827 @default.
• W4385514405 hasConcept C523546767 @default.
• W4385514405 hasConcept C54355233 @default.
• W4385514405 hasConcept C55493867 @default.
• W4385514405 hasConcept C86803240 @default.
• W4385514405 hasConcept C89423630 @default.
• W4385514405 hasConceptScore W4385514405C176947019 @default.
• W4385514405 hasConceptScore W4385514405C178790620 @default.
• W4385514405 hasConceptScore W4385514405C185592680 @default.
• W4385514405 hasConceptScore W4385514405C202751555 @default.
• W4385514405 hasConceptScore W4385514405C26381139 @default.
• W4385514405 hasConceptScore W4385514405C2777052132 @default.
• W4385514405 hasConceptScore W4385514405C2777241463 @default.
• W4385514405 hasConceptScore W4385514405C2778484023 @default.
• W4385514405 hasConceptScore W4385514405C2779489039 @default.
• W4385514405 hasConceptScore W4385514405C2780104969 @default.
• W4385514405 hasConceptScore W4385514405C3019249092 @default.
• W4385514405 hasConceptScore W4385514405C501593827 @default.
• W4385514405 hasConceptScore W4385514405C523546767 @default.
• W4385514405 hasConceptScore W4385514405C54355233 @default.
• W4385514405 hasConceptScore W4385514405C55493867 @default.
• W4385514405 hasConceptScore W4385514405C86803240 @default.
• W4385514405 hasConceptScore W4385514405C89423630 @default.
• W4385514405 hasLocation W43855144051 @default.

• next