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- W4385514406 abstract "Receptor-associated protein inhibits binding and uptake of all known endogenous ligands by megalin and cubilin receptors via unknown mechanism(s). Here, we took advantage of recently generated knockout cell lines to dissect the effect of this protein on megalin- and cubilin-mediated endocytosis. Our study reveals a novel role for receptor-associated protein in blocking megalin-stimulated endocytic uptake of fluid-phase markers and receptor-bound ligands in proximal tubule cells in addition to its direct effect on ligand binding to megalin receptors." @default.
- W4385514406 created "2023-08-04" @default.
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- W4385514406 date "2023-10-01" @default.
- W4385514406 modified "2023-09-23" @default.
- W4385514406 title "Receptor-Associated Protein (RAP) Impairs Ligand Binding to Megalin and Megalin-Dependent Endocytic Flux in Proximal Tubule Cells" @default.
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- W4385514406 doi "https://doi.org/10.1152/ajprenal.00165.2023" @default.
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