Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514448> ?p ?o ?g. }
- W4385514448 endingPage "884" @default.
- W4385514448 startingPage "871" @default.
- W4385514448 abstract "The excessive inflammatory response is known to be a major challenge for diabetic wound healing, while bacteria secreted toxin, α-hemolysin (Hlα), was recently reported to prolong inflammation and delay diabetic wound healing. In this study, we designed a red blood cell membrane (RBCM)-mimicking liposome containing curcumin (named RC-Lip) for the treatment of diabetic wounds. RC-Lips were successfully fabricated using the thin film dispersion method, and the fusion of RBC membrane with the liposomal membrane was confirmed via surface protein analysis. RC-Lips efficiently adsorbed Hlα, thereby reducing the damage and pro-apoptotic effects of Hlα on keratinocytes. Furthermore, they remarkably facilitated liposome uptake into macrophages with advanced curcumin release and regulation of M2 macrophage polarization. In a diabetic mouse and infected wound model, RC-Lips treatment significantly promoted wound healing and re-epithelialization while downregulating interleukin-1β (IL-1β) and upregulating interleukin-10 (IL-10). In summary, the results showed that the spongiform RC-Lips effectively modulate the inflammatory response after adsorbing Hlα and regulating M2 macrophage polarization, leading to a significant promotion of wound healing in diabetic mice. Hence, this study provides a prospective strategy of efficiently mediating inflammatory response for diabetic wounds." @default.
- W4385514448 created "2023-08-04" @default.
- W4385514448 creator A5006274946 @default.
- W4385514448 creator A5010516507 @default.
- W4385514448 creator A5017534437 @default.
- W4385514448 creator A5035111571 @default.
- W4385514448 creator A5038583579 @default.
- W4385514448 creator A5044367029 @default.
- W4385514448 creator A5049486408 @default.
- W4385514448 creator A5054352845 @default.
- W4385514448 creator A5061735047 @default.
- W4385514448 creator A5063239613 @default.
- W4385514448 creator A5063545284 @default.
- W4385514448 creator A5074146802 @default.
- W4385514448 creator A5076097380 @default.
- W4385514448 creator A5082857859 @default.
- W4385514448 creator A5089986454 @default.
- W4385514448 date "2023-09-01" @default.
- W4385514448 modified "2023-10-18" @default.
- W4385514448 title "Red blood cell-mimicking liposomes loading curcumin promote diabetic wound healing" @default.
- W4385514448 cites W1596824448 @default.
- W4385514448 cites W1966945675 @default.
- W4385514448 cites W1969889961 @default.
- W4385514448 cites W1974448472 @default.
- W4385514448 cites W1976194786 @default.
- W4385514448 cites W1976812054 @default.
- W4385514448 cites W1991552237 @default.
- W4385514448 cites W2013351499 @default.
- W4385514448 cites W2042634738 @default.
- W4385514448 cites W2044226849 @default.
- W4385514448 cites W2123109660 @default.
- W4385514448 cites W2126467473 @default.
- W4385514448 cites W2128921449 @default.
- W4385514448 cites W2195753589 @default.
- W4385514448 cites W2301044272 @default.
- W4385514448 cites W2570207263 @default.
- W4385514448 cites W2575180130 @default.
- W4385514448 cites W2604739897 @default.
- W4385514448 cites W2626354203 @default.
- W4385514448 cites W2729854624 @default.
- W4385514448 cites W2748188663 @default.
- W4385514448 cites W2773574399 @default.
- W4385514448 cites W2790463575 @default.
- W4385514448 cites W2794650959 @default.
- W4385514448 cites W2802183954 @default.
- W4385514448 cites W2888070427 @default.
- W4385514448 cites W2888861542 @default.
- W4385514448 cites W2890647279 @default.
- W4385514448 cites W2899844209 @default.
- W4385514448 cites W2902494598 @default.
- W4385514448 cites W2910433925 @default.
- W4385514448 cites W2915171406 @default.
- W4385514448 cites W2921091918 @default.
- W4385514448 cites W2921881633 @default.
- W4385514448 cites W2990512514 @default.
- W4385514448 cites W2999721165 @default.
- W4385514448 cites W3009146872 @default.
- W4385514448 cites W3036276071 @default.
- W4385514448 cites W3036599147 @default.
- W4385514448 cites W3042011458 @default.
- W4385514448 cites W3133005132 @default.
- W4385514448 cites W3176608137 @default.
- W4385514448 cites W3199890004 @default.
- W4385514448 cites W3207258993 @default.
- W4385514448 cites W3208251780 @default.
- W4385514448 cites W4220963671 @default.
- W4385514448 cites W4281868931 @default.
- W4385514448 cites W4283813169 @default.
- W4385514448 doi "https://doi.org/10.1016/j.jconrel.2023.07.049" @default.
- W4385514448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37532149" @default.
- W4385514448 hasPublicationYear "2023" @default.
- W4385514448 type Work @default.
- W4385514448 citedByCount "0" @default.
- W4385514448 crossrefType "journal-article" @default.
- W4385514448 hasAuthorship W4385514448A5006274946 @default.
- W4385514448 hasAuthorship W4385514448A5010516507 @default.
- W4385514448 hasAuthorship W4385514448A5017534437 @default.
- W4385514448 hasAuthorship W4385514448A5035111571 @default.
- W4385514448 hasAuthorship W4385514448A5038583579 @default.
- W4385514448 hasAuthorship W4385514448A5044367029 @default.
- W4385514448 hasAuthorship W4385514448A5049486408 @default.
- W4385514448 hasAuthorship W4385514448A5054352845 @default.
- W4385514448 hasAuthorship W4385514448A5061735047 @default.
- W4385514448 hasAuthorship W4385514448A5063239613 @default.
- W4385514448 hasAuthorship W4385514448A5063545284 @default.
- W4385514448 hasAuthorship W4385514448A5074146802 @default.
- W4385514448 hasAuthorship W4385514448A5076097380 @default.
- W4385514448 hasAuthorship W4385514448A5082857859 @default.
- W4385514448 hasAuthorship W4385514448A5089986454 @default.
- W4385514448 hasConcept C185154212 @default.
- W4385514448 hasConcept C185592680 @default.
- W4385514448 hasConcept C202751555 @default.
- W4385514448 hasConcept C203014093 @default.
- W4385514448 hasConcept C2776682551 @default.
- W4385514448 hasConcept C2776914184 @default.
- W4385514448 hasConcept C2778250585 @default.
- W4385514448 hasConcept C2779244956 @default.
- W4385514448 hasConcept C2780269544 @default.