FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514450> ?p ?o ?g. }

• W4385514450 endingPage "481" @default.
• W4385514450 startingPage "466" @default.
• W4385514450 abstract "The proliferation and migration of vascular smooth muscle cells (VSMCs) play vital roles in the pathogenesis of atherosclerosis and hypertension. It has been proposed and verified that hexahydrocurcumin (HHC), a metabolite form of curcumin, has cardiovascular protective effects. This study examined the effect of HHC on angiotensin II (Ang II)-induced proliferation, migration, and inflammation in rat aortic VSMCs and explored the molecular mechanisms related to the processes. The results showed that HHC significantly suppressed Ang II-induced proliferation, migration, and inflammation in VSMCs. HHC inhibited Ang II-induction of the increase in cyclin D1 and decrease in p21 expression in VSMCs. Moreover, HHC attenuated the generation of reactive oxygen species (ROS), and the expression of nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and matrix metalloproteinases-9 (MMP9) in Ang II-induced VSMCs. The proliferation, migration, inflammation, and ROS production were also inhibited by GKT137831 (NADPH oxidase, NOX1/4 inhibitor) and the combination of HHC and GKT137831. In addition, HHC restored the Ang-II inhibited expression of peroxisome proliferator-activated receptor-γ (PPAR-γ) and peroxisome proliferator activated receptor-γ coactivator-1α (PGC-1α). These findings indicate that HHC may play a protective role in Ang II-promoted proliferation, migration, and inflammation by suppressing NADPH oxidase mediated ROS generation and elevating PPAR-γ and PGC-1α expression. See also Figure 1(Fig. 1)." @default.
• W4385514450 created "2023-08-04" @default.
• W4385514450 creator A5014356405 @default.
• W4385514450 creator A5026011880 @default.
• W4385514450 creator A5035355701 @default.
• W4385514450 creator A5064012487 @default.
• W4385514450 creator A5083855947 @default.
• W4385514450 date "2023-01-01" @default.
• W4385514450 modified "2023-09-23" @default.
• W4385514450 title "Hexahydrocurcumin mitigates angiotensin II-induced proliferation, migration, and inflammation in vascular smooth muscle cells." @default.
• W4385514450 cites W1553579382 @default.
• W4385514450 cites W1865630270 @default.
• W4385514450 cites W1950864690 @default.
• W4385514450 cites W1968286569 @default.
• W4385514450 cites W1973625087 @default.
• W4385514450 cites W1991637750 @default.
• W4385514450 cites W2006244753 @default.
• W4385514450 cites W2006861447 @default.
• W4385514450 cites W2010073511 @default.
• W4385514450 cites W2014180213 @default.
• W4385514450 cites W2018260917 @default.
• W4385514450 cites W2021018857 @default.
• W4385514450 cites W2026849698 @default.
• W4385514450 cites W2035618810 @default.
• W4385514450 cites W2039367380 @default.
• W4385514450 cites W2059643240 @default.
• W4385514450 cites W2076216271 @default.
• W4385514450 cites W2077124137 @default.
• W4385514450 cites W2079178816 @default.
• W4385514450 cites W2098108405 @default.
• W4385514450 cites W2103957625 @default.
• W4385514450 cites W2135412628 @default.
• W4385514450 cites W2144126099 @default.
• W4385514450 cites W2149413458 @default.
• W4385514450 cites W2150020017 @default.
• W4385514450 cites W2155835199 @default.
• W4385514450 cites W2156835140 @default.
• W4385514450 cites W2168975002 @default.
• W4385514450 cites W2315889172 @default.
• W4385514450 cites W2336966193 @default.
• W4385514450 cites W2343423203 @default.
• W4385514450 cites W2518745430 @default.
• W4385514450 cites W2570800839 @default.
• W4385514450 cites W2602099823 @default.
• W4385514450 cites W2774198194 @default.
• W4385514450 cites W2794456899 @default.
• W4385514450 cites W2804950812 @default.
• W4385514450 cites W2892268363 @default.
• W4385514450 cites W2905165749 @default.
• W4385514450 cites W2993751816 @default.
• W4385514450 cites W3080162607 @default.
• W4385514450 cites W4200380098 @default.
• W4385514450 doi "https://doi.org/10.17179/excli2023-6124" @default.
• W4385514450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534221" @default.
• W4385514450 hasPublicationYear "2023" @default.
• W4385514450 type Work @default.
• W4385514450 citedByCount "0" @default.
• W4385514450 crossrefType "journal-article" @default.
• W4385514450 hasAuthorship W4385514450A5014356405 @default.
• W4385514450 hasAuthorship W4385514450A5026011880 @default.
• W4385514450 hasAuthorship W4385514450A5035355701 @default.
• W4385514450 hasAuthorship W4385514450A5064012487 @default.
• W4385514450 hasAuthorship W4385514450A5083855947 @default.
• W4385514450 hasConcept C104317684 @default.
• W4385514450 hasConcept C109523444 @default.
• W4385514450 hasConcept C126322002 @default.
• W4385514450 hasConcept C127561419 @default.
• W4385514450 hasConcept C134018914 @default.
• W4385514450 hasConcept C170493617 @default.
• W4385514450 hasConcept C17991360 @default.
• W4385514450 hasConcept C185592680 @default.
• W4385514450 hasConcept C2775997469 @default.
• W4385514450 hasConcept C2776914184 @default.
• W4385514450 hasConcept C2779395532 @default.
• W4385514450 hasConcept C2779719074 @default.
• W4385514450 hasConcept C2908929049 @default.
• W4385514450 hasConcept C2992686903 @default.
• W4385514450 hasConcept C48349386 @default.
• W4385514450 hasConcept C502942594 @default.
• W4385514450 hasConcept C55493867 @default.
• W4385514450 hasConcept C71924100 @default.
• W4385514450 hasConcept C86803240 @default.
• W4385514450 hasConcept C95444343 @default.
• W4385514450 hasConceptScore W4385514450C104317684 @default.
• W4385514450 hasConceptScore W4385514450C109523444 @default.
• W4385514450 hasConceptScore W4385514450C126322002 @default.
• W4385514450 hasConceptScore W4385514450C127561419 @default.
• W4385514450 hasConceptScore W4385514450C134018914 @default.
• W4385514450 hasConceptScore W4385514450C170493617 @default.
• W4385514450 hasConceptScore W4385514450C17991360 @default.
• W4385514450 hasConceptScore W4385514450C185592680 @default.
• W4385514450 hasConceptScore W4385514450C2775997469 @default.
• W4385514450 hasConceptScore W4385514450C2776914184 @default.
• W4385514450 hasConceptScore W4385514450C2779395532 @default.
• W4385514450 hasConceptScore W4385514450C2779719074 @default.
• W4385514450 hasConceptScore W4385514450C2908929049 @default.
• W4385514450 hasConceptScore W4385514450C2992686903 @default.
• W4385514450 hasConceptScore W4385514450C48349386 @default.

• next