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- W4385514457 abstract "RNA-based therapies, and siRNAs in particular, have attractive therapeutic potential for cancer treatment due to their ability to silence genes that are imperative for tumor progression. To be effective and solve issues related to their poor half-life and poor pharmacokinetic properties, siRNAs require adequate drug delivery systems that protect them from degradation and allow intracellular delivery. Among the various delivery vehicles available, lipid nanoparticles have emerged as the leading choice. These nanoparticles consist of cholesterol, phospholipids, PEG-lipids and most importantly ionizable cationic lipids. These ionizable lipids enable the binding of negatively charged siRNA, resulting in the formation of stable and neutral lipid nanoparticles with exceptionally high encapsulation efficiency. Lipid nanoparticles have demonstrated their effectiveness and versatility in delivering not only siRNAs but also multiple RNA molecules, contributing to their remarkable success. Furthermore, the advancement of efficient manufacturing techniques such as microfluidics, enables the rapid mixing of two miscible solvents without the need for shear forces. This facilitates the reproducible production of lipid nanoparticles and holds enormous potential for scalability. This is shown by the increasing number of preclinical and clinical trials evaluating the potential use of siRNA-LNPs for the treatment of solid and hematological tumors as well as in cancer immunotherapy. In this review, we provide an overview of the progress made on siRNA-LNP development for cancer treatment and outline the current preclinical and clinical landscape in this area. Finally, the translational challenges required to bring siRNA-LNPs further into the clinic are also discussed." @default.
- W4385514457 created "2023-08-04" @default.
- W4385514457 creator A5013234963 @default.
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- W4385514457 creator A5076749233 @default.
- W4385514457 creator A5079698678 @default.
- W4385514457 creator A5090074814 @default.
- W4385514457 date "2023-09-01" @default.
- W4385514457 modified "2023-10-18" @default.
- W4385514457 title "Lipid nanoparticles for siRNA delivery in cancer treatment" @default.
- W4385514457 cites W1499748821 @default.
- W4385514457 cites W1611419331 @default.
- W4385514457 cites W1647075334 @default.
- W4385514457 cites W1843302206 @default.
- W4385514457 cites W1964146045 @default.
- W4385514457 cites W1968242738 @default.
- W4385514457 cites W1971290197 @default.
- W4385514457 cites W1974303227 @default.
- W4385514457 cites W1992366573 @default.
- W4385514457 cites W1993451273 @default.
- W4385514457 cites W2000136129 @default.
- W4385514457 cites W2005856849 @default.
- W4385514457 cites W2006167464 @default.
- W4385514457 cites W2008033906 @default.
- W4385514457 cites W2011784577 @default.
- W4385514457 cites W2014509855 @default.
- W4385514457 cites W2020975942 @default.
- W4385514457 cites W2026674730 @default.
- W4385514457 cites W2037109880 @default.
- W4385514457 cites W2039551908 @default.
- W4385514457 cites W2050064163 @default.
- W4385514457 cites W2053311966 @default.
- W4385514457 cites W2054847598 @default.
- W4385514457 cites W2056380758 @default.
- W4385514457 cites W2080718344 @default.
- W4385514457 cites W2084810036 @default.
- W4385514457 cites W2091395844 @default.
- W4385514457 cites W2092747041 @default.
- W4385514457 cites W2098777190 @default.
- W4385514457 cites W2109386630 @default.
- W4385514457 cites W2114056376 @default.
- W4385514457 cites W2115019462 @default.
- W4385514457 cites W2119784812 @default.
- W4385514457 cites W2125460615 @default.
- W4385514457 cites W2136447541 @default.
- W4385514457 cites W2147655511 @default.
- W4385514457 cites W2154940772 @default.
- W4385514457 cites W2192049920 @default.
- W4385514457 cites W2249755146 @default.
- W4385514457 cites W2285881370 @default.
- W4385514457 cites W2287068442 @default.
- W4385514457 cites W2407515397 @default.
- W4385514457 cites W2502048764 @default.
- W4385514457 cites W2517279530 @default.
- W4385514457 cites W2566902031 @default.
- W4385514457 cites W2589886123 @default.
- W4385514457 cites W2602591481 @default.
- W4385514457 cites W2617388155 @default.
- W4385514457 cites W2766725583 @default.
- W4385514457 cites W2768292016 @default.
- W4385514457 cites W2771155547 @default.
- W4385514457 cites W2782708334 @default.
- W4385514457 cites W2790069484 @default.
- W4385514457 cites W2790347249 @default.
- W4385514457 cites W2795531081 @default.
- W4385514457 cites W2799813152 @default.
- W4385514457 cites W2802435901 @default.
- W4385514457 cites W2804535713 @default.
- W4385514457 cites W2820941669 @default.
- W4385514457 cites W2885302348 @default.
- W4385514457 cites W2885574060 @default.
- W4385514457 cites W2886823346 @default.
- W4385514457 cites W2893168313 @default.
- W4385514457 cites W2907407844 @default.
- W4385514457 cites W2920438880 @default.
- W4385514457 cites W2941514458 @default.
- W4385514457 cites W2946682034 @default.
- W4385514457 cites W2963890011 @default.
- W4385514457 cites W2964873374 @default.
- W4385514457 cites W2968892674 @default.
- W4385514457 cites W2971698746 @default.
- W4385514457 cites W2983721520 @default.
- W4385514457 cites W2984284890 @default.
- W4385514457 cites W2989249514 @default.
- W4385514457 cites W2994237516 @default.
- W4385514457 cites W2995004888 @default.
- W4385514457 cites W2999858469 @default.
- W4385514457 cites W3001039158 @default.
- W4385514457 cites W3002722315 @default.
- W4385514457 cites W3005100376 @default.
- W4385514457 cites W3006737179 @default.
- W4385514457 cites W3010381651 @default.
- W4385514457 cites W3011313923 @default.
- W4385514457 cites W3015098352 @default.
- W4385514457 cites W3021916112 @default.