Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514582> ?p ?o ?g. }
- W4385514582 abstract "Abstract Horizontal gene transfer advances bacterial evolution. To benefit from horizontally acquired genes, enteric bacteria must overcome silencing caused when the widespread heat‐stable nucleoid structuring (H‐NS) protein binds to AT‐rich horizontally acquired genes. This ability had previously been ascribed to both anti‐silencing proteins outcompeting H‐NS for binding to AT‐rich DNA and RNA polymerase initiating transcription from alternative promoters. However, we now know that pathogenic Salmonella enterica serovar Typhimurium and commensal Escherichia coli break down H‐NS when this silencer is not bound to DNA. Curiously, both species use the same protease – Lon – to destroy H‐NS in distinct environments. Anti‐silencing proteins promote the expression of horizontally acquired genes without binding to them by displacing H‐NS from AT‐rich DNA, thus leaving H‐NS susceptible to proteolysis and decreasing H‐NS amounts overall. Conserved amino acid sequences in the Lon protease and H‐NS cleavage site suggest that diverse bacteria degrade H‐NS to exploit horizontally acquired genes." @default.
- W4385514582 created "2023-08-04" @default.
- W4385514582 creator A5063545607 @default.
- W4385514582 creator A5068705735 @default.
- W4385514582 date "2023-08-03" @default.
- W4385514582 modified "2023-10-17" @default.
- W4385514582 title "Advancing evolution: Bacteria break down gene silencer to express horizontally acquired genes" @default.
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- W4385514582 doi "https://doi.org/10.1002/bies.202300062" @default.
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- W4385514582 hasPublicationYear "2023" @default.
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