FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514600> ?p ?o ?g. }

• W4385514600 abstract "Diagnostic criteria for juvenile myelomonocytic leukemia (JMML) are currently well defined, however in some patients diagnosis still remains a challenge. Flow cytometry is a well-established tool for diagnosis and follow-up of hematological malignancies, nevertheless it is not routinely used for JMML diagnosis. Herewith, we characterized the CD34+ hematopoietic precursor cells collected from 31 children with JMML using a combination of standardized EuroFlow antibody panels to assess the ability to discriminate JMML cells from normal/reactive bone marrow cell as controls (n=29) or from cells of children with other hematological diseases mimicking JMML (n=9). CD34+ precursors in JMML showed markedly reduced B and erythroid-committed precursors compared to controls, whereas monocytic and CD7+ lymphoid precursors were significantly expanded. Moreover, aberrant immunophenotypes were consistently present in CD34+ precursors in JMML, while they were virtually absent in controls. Multivariate logistic regression analysis showed that combined assessment of the number of CD34+CD7+ lymphoid precursors and CD34+ aberrant precursors or erythroid precursors had a great potential in discriminating JMMLs vs controls. Importantly our scoring model allowed highly efficient discrimination of truly JMML vs patients with JMML-like diseases. In conclusion, we show for the first time that CD34+ precursors from JMML patients display a unique immunophenotypic profile which might contribute to a fast and accurate diagnosis of JMML worldwide by applying an easy to standardize single 8-color antibody combination." @default.
• W4385514600 created "2023-08-04" @default.
• W4385514600 creator A5002730356 @default.
• W4385514600 creator A5005981561 @default.
• W4385514600 creator A5006790084 @default.
• W4385514600 creator A5022712318 @default.
• W4385514600 creator A5024394710 @default.
• W4385514600 creator A5028824291 @default.
• W4385514600 creator A5044371990 @default.
• W4385514600 creator A5045088100 @default.
• W4385514600 creator A5051520180 @default.
• W4385514600 creator A5051884732 @default.
• W4385514600 creator A5058731031 @default.
• W4385514600 creator A5059228602 @default.
• W4385514600 creator A5064951012 @default.
• W4385514600 creator A5068043845 @default.
• W4385514600 creator A5069240484 @default.
• W4385514600 creator A5071924829 @default.
• W4385514600 creator A5074837498 @default.
• W4385514600 creator A5076937414 @default.
• W4385514600 creator A5077923077 @default.
• W4385514600 creator A5080690615 @default.
• W4385514600 creator A5080792631 @default.
• W4385514600 creator A5083575870 @default.
• W4385514600 creator A5083769556 @default.
• W4385514600 creator A5086290087 @default.
• W4385514600 creator A5088409474 @default.
• W4385514600 creator A5089294201 @default.
• W4385514600 date "2023-08-03" @default.
• W4385514600 modified "2023-10-16" @default.
• W4385514600 title "Phenotypic profiling of CD34+ cells by advanced flow cytometry improves diagnosis of Juvenile Myelomonocytic Leukemia" @default.
• W4385514600 doi "https://doi.org/10.3324/haematol.2023.282805" @default.
• W4385514600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37534527" @default.
• W4385514600 hasPublicationYear "2023" @default.
• W4385514600 type Work @default.
• W4385514600 citedByCount "0" @default.
• W4385514600 crossrefType "journal-article" @default.
• W4385514600 hasAuthorship W4385514600A5002730356 @default.
• W4385514600 hasAuthorship W4385514600A5005981561 @default.
• W4385514600 hasAuthorship W4385514600A5006790084 @default.
• W4385514600 hasAuthorship W4385514600A5022712318 @default.
• W4385514600 hasAuthorship W4385514600A5024394710 @default.
• W4385514600 hasAuthorship W4385514600A5028824291 @default.
• W4385514600 hasAuthorship W4385514600A5044371990 @default.
• W4385514600 hasAuthorship W4385514600A5045088100 @default.
• W4385514600 hasAuthorship W4385514600A5051520180 @default.
• W4385514600 hasAuthorship W4385514600A5051884732 @default.
• W4385514600 hasAuthorship W4385514600A5058731031 @default.
• W4385514600 hasAuthorship W4385514600A5059228602 @default.
• W4385514600 hasAuthorship W4385514600A5064951012 @default.
• W4385514600 hasAuthorship W4385514600A5068043845 @default.
• W4385514600 hasAuthorship W4385514600A5069240484 @default.
• W4385514600 hasAuthorship W4385514600A5071924829 @default.
• W4385514600 hasAuthorship W4385514600A5074837498 @default.
• W4385514600 hasAuthorship W4385514600A5076937414 @default.
• W4385514600 hasAuthorship W4385514600A5077923077 @default.
• W4385514600 hasAuthorship W4385514600A5080690615 @default.
• W4385514600 hasAuthorship W4385514600A5080792631 @default.
• W4385514600 hasAuthorship W4385514600A5083575870 @default.
• W4385514600 hasAuthorship W4385514600A5083769556 @default.
• W4385514600 hasAuthorship W4385514600A5086290087 @default.
• W4385514600 hasAuthorship W4385514600A5088409474 @default.
• W4385514600 hasAuthorship W4385514600A5089294201 @default.
• W4385514600 hasBestOaLocation W43855146001 @default.
• W4385514600 hasConcept C10205521 @default.
• W4385514600 hasConcept C109159458 @default.
• W4385514600 hasConcept C126322002 @default.
• W4385514600 hasConcept C142724271 @default.
• W4385514600 hasConcept C143998085 @default.
• W4385514600 hasConcept C196166836 @default.
• W4385514600 hasConcept C203014093 @default.
• W4385514600 hasConcept C2778461978 @default.
• W4385514600 hasConcept C2779157977 @default.
• W4385514600 hasConcept C2780007613 @default.
• W4385514600 hasConcept C28328180 @default.
• W4385514600 hasConcept C502942594 @default.
• W4385514600 hasConcept C54355233 @default.
• W4385514600 hasConcept C553184892 @default.
• W4385514600 hasConcept C71924100 @default.
• W4385514600 hasConcept C86803240 @default.
• W4385514600 hasConceptScore W4385514600C10205521 @default.
• W4385514600 hasConceptScore W4385514600C109159458 @default.
• W4385514600 hasConceptScore W4385514600C126322002 @default.
• W4385514600 hasConceptScore W4385514600C142724271 @default.
• W4385514600 hasConceptScore W4385514600C143998085 @default.
• W4385514600 hasConceptScore W4385514600C196166836 @default.
• W4385514600 hasConceptScore W4385514600C203014093 @default.
• W4385514600 hasConceptScore W4385514600C2778461978 @default.
• W4385514600 hasConceptScore W4385514600C2779157977 @default.
• W4385514600 hasConceptScore W4385514600C2780007613 @default.
• W4385514600 hasConceptScore W4385514600C28328180 @default.
• W4385514600 hasConceptScore W4385514600C502942594 @default.
• W4385514600 hasConceptScore W4385514600C54355233 @default.
• W4385514600 hasConceptScore W4385514600C553184892 @default.
• W4385514600 hasConceptScore W4385514600C71924100 @default.
• W4385514600 hasConceptScore W4385514600C86803240 @default.
• W4385514600 hasLocation W43855146001 @default.
• W4385514600 hasLocation W43855146002 @default.
• W4385514600 hasOpenAccess W4385514600 @default.
• W4385514600 hasPrimaryLocation W43855146001 @default.

• next