FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514784> ?p ?o ?g. }

• W4385514784 abstract "Abstract Keverprazan, a novel potassium‐competitive acid blocker, was approved for treating acid‐related diseases. This study aimed to analyze the safety, pharmacokinetics (PKs) and pharmacodynamics (PDs) of multiple doses of keverprazan. This was a randomized, positive‐/placebo‐controlled, phase Ic trial. Twenty‐six healthy adults were randomized to receive 20 mg/day keverprazan ( n = 8), 40 mg/day keverprazan ( n = 8), placebo ( n = 6), or 20 mg/day vonoprazan ( n = 4) for 7 days. Safety, PK and PD assessments were conducted. In the keverprazan, vonoprazan, and placebo groups, adverse events (AEs) were reported in nine (56.25%), two (50.00%), and three (50.00%) subjects, respectively. AEs were mild except a moderate abdominal pain leading to withdraw. No serious AEs occurred. The plasma concentration‐time profiles of keverprazan showed rapid absorption (median time to maximum plasma concentration of 1.25–3.0 h). The terminal half‐life was 6.23 and 7.01 h for keverprazan 20 and 40 mg groups on day 7. The maximum plasma concentration was 43.1 and 93.2 ng/mL, respectively. There was no apparent accumulation of keverprazan and the major metabolite after 7‐day administration. The intragastric pH greater than 5 holding time ratios (HTRs) over 24 h postdose increased from 79.1%, 84.4%, and 84.5% on day 1 to 99.0%, 97.4%, and 100.0% on day 7 in the vonoprazan 20 mg and keverprazan 20 and 40 mg groups, respectively. The intragastric pH greater than 5 HTR of keverprazan reached a plateau at 20 mg. Keverprazan is well‐tolerable. A steady‐state in exposure was generally reached after 7 days of treatment. A dose of 20 mg/day keverprazan can elicit a significant, stable, and long‐lasting gastric acid inhibition effect." @default.
• W4385514784 created "2023-08-04" @default.
• W4385514784 creator A5021930138 @default.
• W4385514784 creator A5026071162 @default.
• W4385514784 creator A5029484872 @default.
• W4385514784 creator A5035737049 @default.
• W4385514784 creator A5040643319 @default.
• W4385514784 creator A5054013038 @default.
• W4385514784 creator A5057313063 @default.
• W4385514784 creator A5057741416 @default.
• W4385514784 creator A5061512567 @default.
• W4385514784 date "2023-08-02" @default.
• W4385514784 modified "2023-10-01" @default.
• W4385514784 title "Keverprazan, a novel potassium‐competitive acid blocker: Multiple oral doses safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy subjects" @default.
• W4385514784 cites W1846268769 @default.
• W4385514784 cites W2048548077 @default.
• W4385514784 cites W2072080364 @default.
• W4385514784 cites W2172306046 @default.
• W4385514784 cites W2591504958 @default.
• W4385514784 cites W2625475847 @default.
• W4385514784 cites W2744700122 @default.
• W4385514784 cites W2762214476 @default.
• W4385514784 cites W2801245286 @default.
• W4385514784 cites W2802722762 @default.
• W4385514784 cites W2805335215 @default.
• W4385514784 cites W2903814021 @default.
• W4385514784 cites W2908381102 @default.
• W4385514784 cites W2969713145 @default.
• W4385514784 cites W3047781463 @default.
• W4385514784 cites W3085975422 @default.
• W4385514784 cites W3114355698 @default.
• W4385514784 cites W3117133150 @default.
• W4385514784 cites W3164951660 @default.
• W4385514784 cites W3182302355 @default.
• W4385514784 cites W3195940931 @default.
• W4385514784 cites W3202341449 @default.
• W4385514784 cites W4211029205 @default.
• W4385514784 cites W4221098877 @default.
• W4385514784 cites W4294917733 @default.
• W4385514784 cites W4298326761 @default.
• W4385514784 cites W4304014277 @default.
• W4385514784 doi "https://doi.org/10.1111/cts.13598" @default.
• W4385514784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37533172" @default.
• W4385514784 hasPublicationYear "2023" @default.
• W4385514784 type Work @default.
• W4385514784 citedByCount "1" @default.
• W4385514784 countsByYear W43855147842023 @default.
• W4385514784 crossrefType "journal-article" @default.
• W4385514784 hasAuthorship W4385514784A5021930138 @default.
• W4385514784 hasAuthorship W4385514784A5026071162 @default.
• W4385514784 hasAuthorship W4385514784A5029484872 @default.
• W4385514784 hasAuthorship W4385514784A5035737049 @default.
• W4385514784 hasAuthorship W4385514784A5040643319 @default.
• W4385514784 hasAuthorship W4385514784A5054013038 @default.
• W4385514784 hasAuthorship W4385514784A5057313063 @default.
• W4385514784 hasAuthorship W4385514784A5057741416 @default.
• W4385514784 hasAuthorship W4385514784A5061512567 @default.
• W4385514784 hasBestOaLocation W43855147841 @default.
• W4385514784 hasConcept C111113717 @default.
• W4385514784 hasConcept C112705442 @default.
• W4385514784 hasConcept C126322002 @default.
• W4385514784 hasConcept C142724271 @default.
• W4385514784 hasConcept C168563851 @default.
• W4385514784 hasConcept C197934379 @default.
• W4385514784 hasConcept C204787440 @default.
• W4385514784 hasConcept C27081682 @default.
• W4385514784 hasConcept C2777477808 @default.
• W4385514784 hasConcept C2778375690 @default.
• W4385514784 hasConcept C42219234 @default.
• W4385514784 hasConcept C71924100 @default.
• W4385514784 hasConcept C98274493 @default.
• W4385514784 hasConceptScore W4385514784C111113717 @default.
• W4385514784 hasConceptScore W4385514784C112705442 @default.
• W4385514784 hasConceptScore W4385514784C126322002 @default.
• W4385514784 hasConceptScore W4385514784C142724271 @default.
• W4385514784 hasConceptScore W4385514784C168563851 @default.
• W4385514784 hasConceptScore W4385514784C197934379 @default.
• W4385514784 hasConceptScore W4385514784C204787440 @default.
• W4385514784 hasConceptScore W4385514784C27081682 @default.
• W4385514784 hasConceptScore W4385514784C2777477808 @default.
• W4385514784 hasConceptScore W4385514784C2778375690 @default.
• W4385514784 hasConceptScore W4385514784C42219234 @default.
• W4385514784 hasConceptScore W4385514784C71924100 @default.
• W4385514784 hasConceptScore W4385514784C98274493 @default.
• W4385514784 hasLocation W43855147841 @default.
• W4385514784 hasLocation W43855147842 @default.
• W4385514784 hasOpenAccess W4385514784 @default.
• W4385514784 hasPrimaryLocation W43855147841 @default.
• W4385514784 hasRelatedWork W1830687917 @default.
• W4385514784 hasRelatedWork W1934667138 @default.
• W4385514784 hasRelatedWork W1966047811 @default.
• W4385514784 hasRelatedWork W1976890451 @default.
• W4385514784 hasRelatedWork W2003042623 @default.
• W4385514784 hasRelatedWork W202460821 @default.
• W4385514784 hasRelatedWork W2074207917 @default.
• W4385514784 hasRelatedWork W2090169689 @default.
• W4385514784 hasRelatedWork W2538072326 @default.
• W4385514784 hasRelatedWork W4298086959 @default.
• W4385514784 isParatext "false" @default.
• W4385514784 isRetracted "false" @default.

• next