Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385514954> ?p ?o ?g. }
- W4385514954 abstract "Abstract SARS‐CoV‐2 acute respiratory distress syndrome (ARDS) induces uncontrolled lung inflammation and coagulopathy with high mortality. Anti‐viral drugs and monoclonal antibodies reduce early COVID‐19 severity, but treatments for late‐stage immuno‐thrombotic syndromes and long COVID are limited. Serine protease inhibitors (SERPINS) regulate activated proteases. The myxoma virus‐derived Serp‐1 protein is a secreted immunomodulatory serpin that targets activated thrombotic, thrombolytic, and complement proteases as a self‐defense strategy to combat clearance. Serp‐1 is effective in multiple animal models of inflammatory lung disease and vasculitis. Here, we describe systemic treatment with purified PEGylated Serp‐1 as a therapy for immuno‐coagulopathic complications during ARDS. Treatment with PEGSerp‐1 in two mouse‐adapted SARS‐CoV‐2 models in C57Bl/6 and BALB/c mice reduced lung and heart inflammation, with improved outcomes. PEGSerp‐1 significantly reduced M1 macrophages in the lung and heart by modifying urokinase‐type plasminogen activator receptor (uPAR), thrombotic proteases, and complement membrane attack complex (MAC). Sequential changes in gene expression for uPAR and serpins (complement and plasminogen inhibitors) were observed. PEGSerp‐1 is a highly effective immune‐modulator with therapeutic potential for severe viral ARDS, immuno‐coagulopathic responses, and Long COVID." @default.
- W4385514954 created "2023-08-04" @default.
- W4385514954 creator A5007531675 @default.
- W4385514954 creator A5008353651 @default.
- W4385514954 creator A5021297068 @default.
- W4385514954 creator A5024919676 @default.
- W4385514954 creator A5026330832 @default.
- W4385514954 creator A5026889461 @default.
- W4385514954 creator A5026910548 @default.
- W4385514954 creator A5027662419 @default.
- W4385514954 creator A5028166851 @default.
- W4385514954 creator A5034243440 @default.
- W4385514954 creator A5034744182 @default.
- W4385514954 creator A5040591138 @default.
- W4385514954 creator A5042388892 @default.
- W4385514954 creator A5043327869 @default.
- W4385514954 creator A5044492599 @default.
- W4385514954 creator A5044672869 @default.
- W4385514954 creator A5045616831 @default.
- W4385514954 creator A5048918500 @default.
- W4385514954 creator A5055966268 @default.
- W4385514954 creator A5071021144 @default.
- W4385514954 creator A5075010253 @default.
- W4385514954 creator A5078927993 @default.
- W4385514954 creator A5084834429 @default.
- W4385514954 creator A5085480854 @default.
- W4385514954 creator A5086039900 @default.
- W4385514954 creator A5089171585 @default.
- W4385514954 creator A5089327644 @default.
- W4385514954 creator A5090680669 @default.
- W4385514954 creator A5091823760 @default.
- W4385514954 creator A5092587945 @default.
- W4385514954 creator A5092587946 @default.
- W4385514954 creator A5092587947 @default.
- W4385514954 date "2023-08-03" @default.
- W4385514954 modified "2023-10-17" @default.
- W4385514954 title "Viral anti‐inflammatory serpin reduces immuno‐coagulopathic pathology in <scp>SARS‐CoV</scp>‐2 mouse models of infection" @default.
- W4385514954 cites W141668860 @default.
- W4385514954 cites W1509912507 @default.
- W4385514954 cites W1549306192 @default.
- W4385514954 cites W1946706174 @default.
- W4385514954 cites W1966765317 @default.
- W4385514954 cites W1971054351 @default.
- W4385514954 cites W1991257792 @default.
- W4385514954 cites W2012727559 @default.
- W4385514954 cites W2034777643 @default.
- W4385514954 cites W2043771940 @default.
- W4385514954 cites W2049286784 @default.
- W4385514954 cites W2055602946 @default.
- W4385514954 cites W2056205988 @default.
- W4385514954 cites W2071039804 @default.
- W4385514954 cites W2073234751 @default.
- W4385514954 cites W2074535746 @default.
- W4385514954 cites W2086757832 @default.
- W4385514954 cites W2109064884 @default.
- W4385514954 cites W2121593344 @default.
- W4385514954 cites W2128734424 @default.
- W4385514954 cites W2133671612 @default.
- W4385514954 cites W2146693164 @default.
- W4385514954 cites W2151353824 @default.
- W4385514954 cites W2155819806 @default.
- W4385514954 cites W2197966470 @default.
- W4385514954 cites W2898077322 @default.
- W4385514954 cites W2937096191 @default.
- W4385514954 cites W2979171250 @default.
- W4385514954 cites W2984310662 @default.
- W4385514954 cites W2985415435 @default.
- W4385514954 cites W3014571765 @default.
- W4385514954 cites W3023873927 @default.
- W4385514954 cites W3032936483 @default.
- W4385514954 cites W3036143430 @default.
- W4385514954 cites W3036869070 @default.
- W4385514954 cites W3038526294 @default.
- W4385514954 cites W3046069905 @default.
- W4385514954 cites W3081877184 @default.
- W4385514954 cites W3087207483 @default.
- W4385514954 cites W3091868035 @default.
- W4385514954 cites W3093214735 @default.
- W4385514954 cites W3096430081 @default.
- W4385514954 cites W3112498001 @default.
- W4385514954 cites W3125908954 @default.
- W4385514954 cites W3126802289 @default.
- W4385514954 cites W3131888279 @default.
- W4385514954 cites W3138386527 @default.
- W4385514954 cites W3138747438 @default.
- W4385514954 cites W3139784018 @default.
- W4385514954 cites W3141252978 @default.
- W4385514954 cites W3154923914 @default.
- W4385514954 cites W3160788382 @default.
- W4385514954 cites W3163431457 @default.
- W4385514954 cites W3165449608 @default.
- W4385514954 cites W3174599482 @default.
- W4385514954 cites W3177788652 @default.
- W4385514954 cites W3191351836 @default.
- W4385514954 cites W3199407175 @default.
- W4385514954 cites W4221027163 @default.
- W4385514954 cites W4224316910 @default.
- W4385514954 cites W4226514831 @default.
- W4385514954 cites W4280592918 @default.
- W4385514954 cites W4375955055 @default.